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  4. BMPER Antibody, Biotin conjugated

BMPER Antibody, Biotin conjugated

  • 中文名稱：
    BMPER兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA839829LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) BMPER Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BMPER
  • 別名：
    BMP binding endothelial regulator antibody; BMP binding endothelial regulator precursor protein antibody; BMP-binding endothelial regulator protein antibody; BMPER antibody; BMPER_HUMAN antibody; Bone morphogenetic protein binding endothelial cell precursor derived regulator antibody; Bone morphogenetic protein-binding endothelial cell precursor-derived regulator antibody; CRIM3 antibody; Crossveinless 2 antibody; CV 2 antibody; CV2 antibody; hCV2 antibody; Protein crossveinless 2 antibody; Protein crossveinless-2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human BMP-binding endothelial regulator protein (271-418AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inhibitor of bone morphogenetic protein (BMP) function, it may regulate BMP responsiveness of osteoblasts and chondrocytes.
  • 基因功能參考文獻：
    1. Overexpression of BMPER remarkably enhanced BMP-2-induced osteogenic differentiation, while suppression of BMPER effectively inhibited this process both in vitro and in vivo. PMID: 29518774
    2. that BMPER-modulated BMP pathway activity regulates VE-cadherin expression and vascular barrier function PMID: 27995357
    3. BMPER variants associated with a novel, attenuated subtype of diaphanospondylodysostosis. PMID: 26467725
    4. BMPER-dependent pathway involved in high glucose induced alkaline phosphatase expression in vascular smooth muscle cells. PMID: 26264461
    5. The proangiogenic BMPER effect in endothelial cells is mediated by inhibition of antiangiogenic thrombospondin-1 and enhanced expression and activation of the FGF signaling pathway that is crucial in the promotion of angiogenesis. PMID: 25503991
    6. BMPER is a novel regulator of the osteoblast-like differentiation of HCASMCs. PMID: 22778264
    7. Bmper is a critical regulator of Bmp-mediated vascular inflammation and that the fine-tuning of Bmp and Bmper levels is essential in the maintenance of normal vascular homeostasis. PMID: 22772758
    8. The data unequivocally demonstrated that BMPER is highly expressed in malignant tumors and that the growth of lung, colon, and uterine carcinomas is dependent on the presence of BMPER. PMID: 22020334
    9. Mutual regulation by BMP-9 and CV2 is essential in regulating the development of the vascular endothelium. PMID: 22474252
    10. Diaphonospondylodysostosis is caused by loss of BMPER function. PMID: 21990102
    11. BMPER-mediated signaling plays an essential role in vertebral segmentation early in human development, while defects in BMPER produce Diaphanospondylodysostosis. PMID: 20869035
    12. BMPER is a novel BMP-binding protein that is expressed by endothelial cell precursors, has BMP-antagonizing activity, and may play a role in endothelial cell differentiation by modulating local BMP activity PMID: 12897139
    13. Crossveinless-2 is an inhibitor of BMP function PMID: 14766204
    14. BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis. PMID: 18787191

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  • 相關疾病：
    Diaphanospondylodysostosis (DSD)
  • 亞細胞定位：
    Secreted.
  • 組織特異性：
    Highly expressed in lung, and brain and also in primary chondrocytes.
  • 數據庫鏈接：

    HGNC: 24154

    OMIM: 608022

    KEGG: hsa:168667

    STRING: 9606.ENSP00000297161

    UniGene: Hs.660998



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