在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BLNK Antibody

BLNK Antibody

  • 中文名稱：
    BLNK兔多克隆抗體
  • 貨號：
    CSB-PA002717GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AGM4 antibody; B cell adapter containing SH2 domain protein antibody; B cell adapter containing Src homology 2 domain protein antibody; B cell adaptor containing SH2 domain antibody; B cell linker antibody; B cell linker protein antibody; B cell-specific adaptor protein antibody; B-cell activation antibody; B-cell adapter containing a SH2 domain protein antibody; B-cell adapter containing a Src homology 2 domain protein antibody; B-cell linker protein antibody; BASH antibody; Bca antibody; BLNK antibody; BLNK s antibody; BLNK_HUMAN antibody; Cytoplasmic adapter protein antibody; Ly 57 antibody; Ly57 antibody; Lymphocyte antigen 57 antibody; Lyw 57 antibody; Lyw57 antibody; MGC111051 antibody; SH2 domain-containing leukocyte protein; 65-KD antibody; SLP 65 antibody; SLP-65 antibody; SLP65 antibody; Src homology [SH2] domain-containing leukocyte protein of 65 kD antibody; Src homology 2 domain containing leukocyte protein of 65 kDa antibody; Src homology 2 domain-containing leukocyte protein of 65 kDa antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human BLNK
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
  • 基因功能參考文獻：
    1. vesicular signaling scaffolds are required for B cell activation indicates that vesicles may deliver preassembled signaling cargo to sites of BCR activation. PMID: 25140054
    2. early Ca(2+) fluxing provides feed-forward signal amplification by promoting anchoring of the PLCgamma2 C2 domain to phospho-SLP65. PMID: 24166973
    3. up-regulation of BLNK is associated with RUNX1 mutations in cytogenetically normal acute myeloid leukemia. PMID: 22689681
    4. Live cell imaging and co-immunoprecipitation experiments confirmed that both SLP65 and CIN85 are both required for the onset and progression phases of B-cell antigen receptor signal transduction. PMID: 21822214
    5. 16 of the 34 childhood pre-B acute lymphoblastic leukaemia samples that were tested showed a complete loss or drastic reduction of SLP-65 expression PMID: 12761551
    6. The BLNK protein is present in the majority of mediastinal B cell lymphomas. PMID: 15744341
    7. In B cells SLP-65 exists in a 180 kDa complex as well as in monomeric form. PMID: 16356554
    8. V(H) gene rearrangement represents a frequent feature in B-lymphoid malignancy, which can be attributed to SLP65 deficiency in many cases. PMID: 16636677
    9. Syk is required to link phosphorylated SLP-65 to Ca(2+) mobilization. PMID: 17681949
    10. Plasmacytoid dendritic cells express a signalosome consisting of Lyn, Syk, Btk, Slp65 (Blnk) and PLCgamma2. Triggering CD303 leads to tyrosine phosphorylation of Syk, Slp65, PLCgamma2 & cytoskeletal proteins. PMID: 18022864
    11. BLNK prevents aneuploidy by inhibiting cytokinesis. PMID: 19018766
    12. BLNK recruits active H-Ras to the BCR complex, which is essential for sustained surface expression of BCR in the form of the cap and for the signal leading to functional ERK activation PMID: 19218240
    13. Data show that SLP-65 phosphorylation acts upstream for signal initiation and also downstream during selective processing of the B cell receptor signal. PMID: 19372136
    14. Identifies BLNK as a potential target for the protein-tyrosine phosphatase SHP-1. PMID: 15588985

    顯示更多

    收起更多

  • 相關疾病：
    Agammaglobulinemia 4, autosomal recessive (AGM4)
  • 亞細胞定位：
    Cytoplasm. Cell membrane. Note=BCR activation results in the translocation to membrane fraction.
  • 組織特異性：
    Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
  • 數據庫鏈接：

    HGNC: 14211

    OMIM: 604515

    KEGG: hsa:29760

    STRING: 9606.ENSP00000224337

    UniGene: Hs.665244



主站蜘蛛池模板： 欧美天天拍在线视频| 欲色影视天天一区二区三区色香欲| 中文字幕无码专区一va亚洲v专区在线 | 国产乱人伦av在线麻豆a| 97色伦午夜国产亚洲精品| 伊人久久大香线蕉av网| 国产成人无码a区视频在线观看 | 少妇人妻无码专区毛片| 无码午夜人妻一区二区三区不卡视频| 国产成人精品123区免费视频| 国产成人精品日本亚洲77上位| 无码av中文字幕免费放| 久久综合狠狠综合久久综| 蜜桃麻豆www久久国产sex| 日本熟妇中文字幕三级| 色噜噜狠狠一区二区三区| 精品无码久久久久国产手机版| 久久精品aⅴ无码中文字字幕不卡| 99国产欧美久久久精品 | 国产日韩欧美久久久精品图片| 久久久久久无码精品人妻a片软件| 印度女人狂野牲交| 毛片免费视频肛交颜射免费视频| 欧美xxxxx高潮喷水麻豆| 午夜伦4480yy私人影院久久| 无码av专区丝袜专区| 欧美丰满熟妇xx猛交| 国产人妻aⅴ色偷| 中文字幕一区二区精品区| 欧美变态口味重另类在线视频 | 无码av动漫精品一区二区免费| 人人妻人人澡人人爽偷拍台湾| 久久久亚洲精品一区二区三区浴池| 久久久久久国产精品无码超碰 | 色哟哟精品视频在线观看| 色婷婷综合激情综在线播放| 青草视频在线观看视频| 日产乱码一二三区别免费麻豆 | 中文字幕在线观看| 久99视频精品免费观看福利| 一边吃奶一边添p好爽高清视频|