在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. BCL2L10 Antibody

BCL2L10 Antibody

  • 中文名稱：
    BCL2L10兔多克隆抗體
  • 貨號：
    CSB-PA884627LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA884627LA01HU diluted at 1:150 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA884627LA01HU diluted at 1:150 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of A549 cells with CSB-PA884627LA01HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) BCL2L10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    BCL2L10
  • 別名：
    BCL2L10; BCLB; Bcl-2-like protein 10; Bcl2-L-10; Anti-apoptotic protein NrH; Apoptosis regulator Bcl-B
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Bcl-2-like protein 10 protein (19-127AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，BCL2L10 Antibody (CSB-PA884627LA01HU)，的標記方式是Non-conjugated。對于BCL2L10 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA884627LB01HU BCL2L10 Antibody, HRP conjugated ELISA
    FITC CSB-PA884627LC01HU BCL2L10 Antibody, FITC conjugated
    Biotin CSB-PA884627LD01HU BCL2L10 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Promotes cell survival by suppressing apoptosis induced by BAX but not BAK. Increases binding of AHCYL1/IRBIT to ITPR1. Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions. Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis.
  • 基因功能參考文獻：
    1. marrow BCL2L10 positive cells may be a biomarker for azacitidine response and OS, with a potential impact in clinical practice. PMID: 28514758
    2. These results suggest that by inhibiting Bcl2l10 activity and promoting contact between endoplasmic reticulum and mitochondria, IRBIT facilitates massive Ca(2+) transfer to mitochondria and promotes apoptosis. PMID: 27995898
    3. we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder. Using whole-genome sequencing, we delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis. PMID: 27260655
    4. Results found that BCL2L10 was down-regulated in human hepatocellular carcinoma (HCC) tissues; its overexpression suppresses cell growth and migration of HCC cell lines. These results suggested that BCL2L10 functions as a tumor-suppressor in HCC. PMID: 27770580
    5. BCLB expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC cells through the adenosine monophosphate-activated protein kinase AMPK-mTOR signaling cascade. PMID: 28259820
    6. Identification of a variant in the BCL2L10 gene as a protective factor for the development of therapy-related myeloid neoplasms and de novo myelodysplastic syndrome. PMID: 24047476
    7. polyubiquitination and proteasomal turnover dictate the expression level and anti-apoptotic capacity of Bcl-B PMID: 23563182
    8. Data suggest that BCL2L10 is localized predominantly to mitochondria in high-quality preimplantation embryos/blastocysts; in contrast, abnormal embryos/blastocysts exhibit extra-mitochondrial localization (cytoplasm/cell nucleus) of BCL2L10. PMID: 23293224
    9. Bcl-B in complex with the BH3 motif of Bim protected cells from Bax-dependent apoptotic pathways. PMID: 23235460
    10. Bcl-B interacts with the BH3 domain of BECN1 and Bcl-B overexpression reduces autophagy triggered by a variety of pro-autophagic stimuli. PMID: 22498477
    11. expression is predictive of azacitidine-resistance in myelodysplastic syndrome patients PMID: 22577154
    12. Ubqln stabilizes BCLb protein, while also promoting monoubiquitination on multiple lysine residues and relocation to the cytosol. PMID: 22233804
    13. BCL2L10 methylation is associated with myelodysplastic syndromes. PMID: 21760590
    14. Loss of BCL2L10 protein expression predicts poor clinical outcome in gastric carcinoma. PMID: 21166696
    15. The apoptotic gene BCL2L10 is a frequent target for aberrant promoter methylation in patients with acute leukemia, de novo and therapy-related. PMID: 21077739
    16. The pro-apoptotic effect of BCL2L10 and growth promotion by BCL2L10 siRNA in gastric cancer cells suggest that it may be a tumour suppressor. PMID: 21171085
    17. study evaluates 3D structure of Bcl-2L10 protein using homology modeling and aims to understand plausible functional and binding interactions between Bcl-2L10 with BH3 domain of BAX using protein - protein docking PMID: 20919753
    18. BCL2L10 is frequently silenced by promoter hypermethylation in gastric cancer. PMID: 20428828
    19. Thus, these results indicate the existence of a previously undiscovered mechanism by which NM23-H2 involves in the regulation of Diva-mediated apoptosis. PMID: 17532299
    20. distinctions in the behaviors of Bcl-B and Mcl-1 relative to the other anti-apoptotic Bcl-2 family members, where Bcl-B and Mcl-1 display reciprocal abilities to bind and neutralize Bax and Bak. PMID: 18178565
    21. Tumor-specific alterations in Bcl-B expression may define subsets of nonepithelial and epithelial neoplasms with distinct clinical behaviors. PMID: 18483366
    22. Interaction of endogenous proteins of BCL2L10 and HIP1R in 293T cells was determined by immunoprecipitation, and their direct association was confirmed by the Far-Western analysis. PMID: 19255499
    23. BCL2L10 Is a novel and prime candidate related to oocyte maturation, fertility, and embryo developmental competence PMID: 19551325

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion. Nucleus membrane. Endoplasmic reticulum.
  • 蛋白家族：
    Bcl-2 family
  • 組織特異性：
    Widely expressed in adult tissues. Preferentially expressed in lung, liver and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 993

    OMIM: 606910

    KEGG: hsa:10017

    STRING: 9606.ENSP00000260442

    UniGene: Hs.283672



主站蜘蛛池模板： 在线精品亚洲一区二区| 国产精品久久久久久久久软件| 欧美亚洲综合成人专区| 中国熟妇内谢69xxxxx| 熟女少妇丰满一区二区| 熟妇女人妻丰满少妇中文字幕| 男女车车的车车网站w98免费| 麻婆豆传媒一区二区三区| 日日av拍夜夜添久久免费| 天躁夜夜躁狼狠躁| 午夜视频久久久久一区| 亚洲精品卡一卡三卡四卡乱码| 国产日韩一区二区三区在线观看 | 国产色视频一区二区三区| 亚洲中文色欧另类欧美| 正在播放酒店约少妇高潮| 欧美精品一区二区三区在线| 中文字幕在线免费看线人| a∨变态另类天堂无码专区| 邪恶肉肉全彩色无遮盖| 少妇人妻真实偷人精品视频| 国产精品无码mv在线观看| 丰满多毛的陰户视频| 又黄又爽的60分钟视频| 欧美内射rape视频| 亚洲欧洲日韩国内高清| 久久高清超碰av热热久久| 制服丝袜中文字幕在线| 精品久久久久久久久中文字幕| 国产在线播放精品视频| 夜夜高潮夜夜爽夜夜爱爱| 老外和中国女人毛片免费视频| 永久免费观看黄网视频| 国产剧情无码播放在线看| 中文在线8资源库| 久久久久久亚洲精品成人| 久久成人网站亚洲综合| 亚洲国产精品嫩草影院| 久久99精品国产麻豆蜜芽| 欧美日本特级婬片视频| 久久国产精品久久精品国产|