在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

BCCIP Antibody

  • 中文名稱:
    BCCIP兔多克隆抗體
  • 貨號:
    CSB-PA002602GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    BCCIP
  • 別名:
    bccip antibody; BCCIP_HUMAN antibody; BCCIPalpha antibody; BCCIPbeta antibody; BRCA2 and CDKN1A interacting protein antibody; BRCA2 and CDKN1A-interacting protein antibody; BRCA2 and Cip1/p21 interacting protein antibody; Cdk inhibitor p21 binding protein antibody; P21 and CDK associated protein 1 antibody; P21- and CDK-associated protein 1 antibody; Protein TOK-1 antibody; Protein TOK1 antibody; TOK 1 antibody; TOK 1alpha antibody; TOK 1beta antibody; TOK1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human BCCIP
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole. Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta. May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ).
  • 基因功能參考文獻:
    1. We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1, p53, and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation PMID: 29047390
    2. BCCIPbeta, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development. PMID: 28510697
    3. this study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression. PMID: 28394342
    4. Expression of BCCIP beta was notably higher in tumor tissues of esophageal squamous cell carcinoma (ESCC) and Eca 109 cells. In vitro studies such as starvation and refeeding assay along with BCCIP beta-shRNA transfection assay demonstrated that BCCIP beta expression promoted proliferation of ESCC cells. PMID: 27995408
    5. we demonstrate that BCCIPbeta induces a conformational change within the RAD51 filament that promotes release of ADP to help maintain an active presynaptic filament. Our findings reveal a functional role for BCCIPbeta as a RAD51 accessory factor in HR. PMID: 27694622
    6. The BCCIPbeta, but not BCCIPalpha, interacts with EIF6 and RPL23/UL14 and stabilizes the latter. PMID: 25150171
    7. Results indicate that BCCIP germ line mutations are unlikely to be a major contributor to familial breast/ovarian cancer risk in our population. PMID: 23911796
    8. In BRCA2, two novel frame shift mutations were identified as 5073-5074delCT and 6866delC. PMID: 11748848
    9. BRCA2 germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 mutations, since survival is higher among breast cancer patients carrying a BRCA2 mutation compared to sporadic breast cancers. PMID: 11754111
    10. Unique de novo mutation of BRCA2 has been identified in a woman with early onset breast cancer. PMID: 11836363
    11. Overexpression of BCCIP beta delays the G1 to S progression and results in an elevated p21 expression PMID: 14726710
    12. BCCIP is critical for BRCA2- and RAD51-dependent responses to DNA damage and homologous recombinational repair. PMID: 15713648
    13. BCCIP in maintaining the transactivation activity of wild type p53; down-regulation of BCCIP as a novel mechanism to impair the p53 function in cells harboring wild type p53 PMID: 17135243
    14. suggest an essential role of BCCIP in the maintenance of genomic integrity PMID: 17452982
    15. BCCIP-dependent repair of double strand breaks by homologous recombination is an early RAD51 response to ionizing radiation-induced DNA damage. PMID: 18413737
    16. LYRIC/AEG-1 is a negative regulator of BCCIPalpha, promoting proteasomal degradation either through direct interaction, or potentially through an indirect mechanism involving downstream effects of the NF-kappaB signaling pathway. PMID: 18440304
    17. BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. PMID: 18773424
    18. BCCIP protein expression was not detectable in approximately 45% of all astrocytic tumors. PMID: 19653894
    19. regulation of p21 intracellular distribution is a new mechanism for BCCIP to modulate p21 functions PMID: 19713748

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, spindle pole.; [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.; [Isoform 2]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族:
    BCP1 family
  • 組織特異性:
    Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.
  • 數據庫鏈接:

    HGNC: 978

    OMIM: 611883

    KEGG: hsa:56647

    STRING: 9606.ENSP00000357748

    UniGene: Hs.370292



主站蜘蛛池模板: 日本高清在线一区二区三区| 粗大猛烈进出高潮视频| 国产女人乱人伦精品一区二区| 国内精品自在自线| 精品国产一区二区三区色欲| 思思99re6国产在线播放| 亚洲欧美v国产蜜芽tv| 亚洲国产精品隔壁老王| 九九久re8在线精品视频| 亚洲精品久久久久午夜福利| 久久精品国产丝袜人妻| 中文字幕人妻熟女人妻洋洋| 亚洲国产成av人天堂无码| 欧美日韩无线码在线观看| 免费大片黄在线观看| 久人人爽人人爽人人片av| 日韩中文字幕区一区有砖一区| 久久视频这里只精品99| 乱人伦中文无码视频| 色135综合网| 无码av最新无码av专区| 无码av中文一区二区三区| 内射人妻少妇无码一本一道 | 又硬又粗进去好爽免费| 亚洲 欧美 综合 另类 中字| 日本护士毛茸茸高潮| 超碰国产天天做天天爽| 国产成人av大片在线播放| 丰满五十六十老熟女hd| 日日碰狠狠躁久久躁2023| 久久国产乱子精品免费女| 上司人妻互换中文字幕| 国产成人亚洲综合无码精品| 国产亚洲精品久久久性色情软件 | 伊人久久精品一区二区三区| 亚无码乱人伦一区二区| 精品亚洲成a人片在线观看| 熟女少妇丰满一区二区| 天堂中文8资源在线8| 国产日产亚洲系列最新美使用方法| 最近日本mv字幕免费高清完整版|