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  4. B4GALNT1 Antibody

B4GALNT1 Antibody

  • 中文名稱：
    B4GALNT1兔多克隆抗體
  • 貨號：
    CSB-PA189953
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HeLa cells, K562 cells, HepG2 cells and HuvEC cells, using B4GALNT1 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) B4GALNT1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    B4GALNT1
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from internal of Human B4GALNT1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Involved in the biosynthesis of gangliosides GM2, GD2, GT2 and GA2 from GM3, GD3, GT3 and GA3, respectively.
  • 基因功能參考文獻：
    1. Data suggest that ganglioside glycosyltransferases ST3GAL5, ST8SIA1, and B4GALNT1 are S-acylated at conserved cysteine residues located close to cytoplasmic border of their transmembrane domains; ST3Gal-II is acylated at conserved cysteine residue in N-terminal cytoplasmic tail; for B4GALNT1 and ST3Gal-II, dimer formation controls their S-acylation status. PMID: 28698248
    2. Novel B4GALNT1 mutations reported in two families with hereditary spastic paraplegia. PMID: 24283893
    3. The resukts of this study identified mutations in B4GALNT1 (GM2 synthase), encoding the enzyme that catalyzes the second step in complex ganglioside biosynthesis, as the cause of this neurodegenerative phenotype. PMID: 24103911
    4. Minimally disseminated disease in high risk retinoblastoma patients was detected using reverse transcriptase PCR for GD2 synthase mRNA in CSF. PMID: 23721779
    5. Molecular upstaging of GalNAc-T using rt-pcr was correlated with prognosis in melanoma patients PMID: 21135695
    6. GD2/GM2 is not a reliable biomarker in small cell lung carcinoma PMID: 19457569
    7. The expression of three messengers coding for SAT-1, SAT-2 and GalNAcT-1 in human samples of intestinal cancer and some cell lines (breast cancer and melanomas), was evaluated. PMID: 17119850
    8. Transmission disequilibrium test and case-control analysis did not detect an association of B4GALNT1 gene with T1DM. PMID: 19318031

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  • 相關(guān)疾?。?/div>
    Spastic paraplegia 26, autosomal recessive (SPG26)
  • 亞細胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Glycosyltransferase 2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4117

    OMIM: 601873

    KEGG: hsa:2583

    STRING: 9606.ENSP00000341562

    UniGene: Hs.159481



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