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Adh5 Antibody

  • 中文名稱:
    Adh5兔多克隆抗體
  • 貨號:
    CSB-PA001357LA01MO
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Adh5 antibody at 2µg/ml
      Lane 1: Mouse liver tissue
      Lane 2: Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 40 kDa
      Observed band size: 40 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Mus musculus (Mouse) Adh5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    Adh5
  • 別名:
    Adh5 antibody; Adh-2 antibody; Adh2 antibody; Alcohol dehydrogenase class-3 antibody; EC 1.1.1.1 antibody; Alcohol dehydrogenase 2 antibody; Alcohol dehydrogenase 5 antibody; Alcohol dehydrogenase B2 antibody; ADH-B2 antibody; Alcohol dehydrogenase class-III antibody; Glutathione-dependent formaldehyde dehydrogenase antibody; FALDH antibody; FDH antibody; GSH-FDH antibody; EC 1.1.1.- antibody; S-(hydroxymethyl)glutathione dehydrogenase antibody; EC 1.1.1.284 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Mouse
  • 免疫原:
    Recombinant Mouse Alcohol dehydrogenase class-3 protein (2-374AA)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,Adh5 Antibody (CSB-PA001357LA01MO),的標記方式是Non-conjugated。對于Adh5 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001357LB01MO Adh5 Antibody, HRP conjugated ELISA
    FITC CSB-PA001357LC01MO Adh5 Antibody, FITC conjugated
    Biotin CSB-PA001357LD01MO Adh5 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol.
  • 基因功能參考文獻:
    1. Site-directed mutagenesis of Akt at Cys224 revealed that S-nitrosylation at this site was pivotal for the reduced phosphorylation at Akt Ser473, which led to impaired Akt signaling. Furthermore, on HHcy challenge, as compared with GSNOR(+/+)ApoE(-/-) littermate controls, GSNOR(-/-)ApoE(-/-) double knockout mice showed reduced T-cell activation with concurrent reduction of atherosclerosis. PMID: 29860106
    2. Data (including data from studies using knockout and transgenic mice) suggest that obesity and diabetes are accompanied by decreases in GSNOR activity in hepatocytes engendering nitrosative stress; obesity promotes S-nitrosylation of lysosomal proteins in liver, thereby impairing lysosomal enzyme activities and compromising autophagy. PMID: 29074597
    3. Report inhibition of GSNOR activity by nebivolol leading to accumulation of nitrosothiols in cells, and this is associated with an enhanced vasodilation by S-nitrosoglutathione. PMID: 26746429
    4. Increased GSNOR expression during aging decreases S-nitrosation of CaMKIIalpha and reduces CaMKIIalpha synaptosomal accumulation. PMID: 28883020
    5. These data indicate a role for GSNOR in the host response to malaria infection and suggest that strategies to disrupt its activity will improve clinical outcomes. PMID: 28674030
    6. GSNOR may act as a "brake" on skeletal muscle contractile performance under physiological conditions by modulating nitrosylation/denitrosylation balance. PMID: 27412893
    7. Loss of GSNOR confers enhanced post-MI cardiac regenerative activity, characterized by enhanced turnover of cardiomyocytes and cardiac stem cells. PMID: 26178404
    8. Results show that ADH5 removes endogenous formaldehyde to prevent DNA adducts, and protects with FANCD2, hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage. PMID: 26412304
    9. S-nitrosoglutathione reductase-dependent modification of PPARgamma alters the balance between adipocyte and osteoblast differentiation and provides checkpoint regulation of the lineage bifurcation of these 2 lineages. PMID: 25798618
    10. These findings provide novel insights into the involvement of GSNOR and S-nitrosylation in neuromuscular atrophy and neuropathic pain that are associated with pathological states. PMID: 24684653
    11. Overexpression of ADH5 reduces both development and adult neuronal differentiation of neurons. This effect depends on the catalytic activity of ADH5 and involves ADH5-mediated denitrosation of histone deacetylase 2 (HDAC2). PMID: 24895131
    12. GSNOR appears to play a crucial role in controlling pulmonary and systemic infection by K. pneumoniae. PMID: 24239886
    13. A critical role for GSNOR in maintaining genomic integrity. PMID: 23354311
    14. This study suggests that S-nitrosoglutathione reductase degradation of S-nitrosoglutathione is a vital step in the expression of ventilatory roll-off PMID: 23183419
    15. GSNOR deficiency has a role in hepatocarcinogenesis, which is prevented by iNOS inhibition PMID: 23440427
    16. Increasing the denitrosylation capacity of cardiomyocytes, via cardiomyocyte-specific overexpression of GSNOR, protects against sepsis-induced myocardial depression. PMID: 23417863
    17. Compared the protein expression profiles in the livers of wild-type and GSNOR-deficient (GSNOR(-/-) ) mice that were challenged with lipopolysaccharide; subsequently id'd 19 upregulated and 19 downregulated proteins in GSNOR(-/-) mice using mass spec. PMID: 22623366
    18. These results indicate that systemic hemodynamic responses (vascular tone and cardiac contractility), both under basal conditions and after adrenergic activation, are regulated through concerted actions of NO synthase/GSNOR. PMID: 22366318
    19. protection of AGT and resistance to nitrosamine-induced genotoxicity critically depends on GSNOR in hepatocytes PMID: 21385828
    20. Data show that GSNO-R activity was elevated in lung homogenates from female compared to male mice. PMID: 21103380
    21. GSNOR denitrosylates connexin 43 at the gap junctions between vascular epithelial and vascular smooth muscle cells. PMID: 21071693
    22. GSNOR, likely through regulation of S-nitrosylation and apoptosis, physiologically plays a protective role in the development of the immune system. PMID: 20980633
    23. Data suggest that GSNOR deficiency, through dysregulated S-nitrosylation, may promote hepatocellular carcinoma, possibly by inactivating a DNA repair system. PMID: 20371487
    24. following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs) PMID: 15919956
    25. Mechanisms are presented through which nitric acid and S-glutathione mediate nitrosative stress, as well as the cellular pathways of protein S-nitrosylation and denitrosylation involving GSNO reductase. PMID: 19138101
    26. GSNOR inhibitors to be novel tools for regulating nitric oxide bioactivity and assessing the role of SNOs in vivo. PMID: 19596685

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  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Zinc-containing alcohol dehydrogenase family, Class-III subfamily
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:


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