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Acta1 Antibody

  • 中文名稱:
    Acta1兔多克隆抗體
  • 貨號(hào):
    CSB-PA00750E0Rb
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Acta1 antibody at 2µg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Mouse lung tissue
      Lane 3: Rat muscle tissue
      Lane 4: Zebrafish lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 43 kDa
      Observed band size: 43 kDa
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Mus musculus (Mouse) Acta1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Acta1 antibody; ActaActin antibody; alpha skeletal muscle antibody; Alpha-actin-1) [Cleaved into: Actin antibody; alpha skeletal muscle antibody; intermediate form] antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Mouse, Rat, Zebrafish
  • 免疫原:
    Mouse Actin, alpha skeletal muscle (Native Protein)
  • 免疫原種屬:
    Mus musculus (Mouse)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,Acta1 Antibody (CSB-PA00750E0Rb),的標(biāo)記方式是Non-conjugated。對(duì)于Acta1 Antibody,我們還提供其他標(biāo)記。見(jiàn)下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA00750F0Rb Acta1 Antibody, HRP conjugated ELISA
    FITC CSB-PA00750G0Rb Acta1 Antibody, FITC conjugated
    Biotin CSB-PA00750H0Rb Acta1 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
  • 基因功能參考文獻(xiàn):
    1. alpha smooth muscle actin (alphaSMA) was identified as a marker of osteoprogenitor cells in bone and periodontium. PMID: 26721734
    2. WIP is a link between membrane lipid composition and actin cytoskeleton at dendritic spines. PMID: 24698977
    3. ACTA1(Asp286Gly) mouse model of nemaline myopathy provide evidence of impaired in vivo muscle function, altered muscle structure and disturbed energy metabolism. PMID: 23977274
    4. Combined MRI and (3)(1)P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism. PMID: 23613869
    5. Data indicate roles for linkers of nucleus to cytoskeleton (LINC) molecules nesprin2giant and nesprin3, which anchor actin cap fibers to the nucleus. PMID: 23336069
    6. Asp286Gly acts as a "poison-protein" and according to the computational analysis it modifies the actin-actin interface. This phenomenon is likely to prevent proper myosin cross-bridge binding. PMID: 23029319
    7. Data show that upon actin binding, the two domains of utrophin become dramatically separated and ordered, indicating a transition to a single open and extended conformation. PMID: 21768337
    8. Data indicated that CacyBP/SIP could simultaneously interact with tubulin and actin, suggesting that CacyBP/SIP might link actin and tubulin cytoskeletons. PMID: 20637809
    9. Results provide the genetic proof that platelet production from megakaryocytes strictly requires dynamic changes in the actin cytoskeleton. PMID: 20530287
    10. Data show that while increases in cardiac and vascular smooth-muscle actin can partially compensate for the lack of skeletal actin in null mice, this is not sufficient to support adequate skeletal muscle growth and/or function. PMID: 12138199
    11. alpha-skeletal-muscle actin mutations have roles in development of myopathies PMID: 15226407
    12. myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25. PMID: 15499557
    13. K+-depolarization increased Tnni1 and Acta1 mRNA levels in both differentiated C2C12 and rat skeletal muscle cells in primary culture PMID: 17146758
    14. Myotubes are a suitable system to study the capacity of a mutant to incorporate into actin structures or to form or induce pathological changes. PMID: 17227580
    15. Val163Met mutation in alpha-skeletal actin can affect the dynamics of other actin isoforms and severely disrupt sarcomeric structure, processes that can contribute to muscle weakness. PMID: 17705262
    16. F- and G-actin concentrations in lamellipodia are about 500 microM & 150 microM, respectively. The excess of G-actin shows that the polymerization rate is not limited by diffusion & is tightly controlled by polymerization/depolymerization modulators. PMID: 19277198

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  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Actin family
  • 數(shù)據(jù)庫(kù)鏈接:


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