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AURKAIP1 Antibody

  • 中文名稱：
    AURKAIP1兔多克隆抗體
  • 貨號：
    CSB-PA794202
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human testis tissue, Primary antibody: CSB-PA794202(AURKAIP1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    AURKAIP1
  • 別名：
    28S ribosomal protein S38 antibody; AIP antibody; AKIP_HUMAN antibody; AURKA interacting protein antibody; AURKA-interacting protein antibody; AURKAIP 1 antibody; Aurkaip1 antibody; Aurora A kinase interacting protein antibody; Aurora kinase A interacting protein 1 antibody; Aurora kinase A-interacting protein antibody; FLJ20608 antibody; mitochondrial antibody; MRP-S38 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human AURKAIP1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
  • 基因功能參考文獻：
    1. Encodes a mitochondrial protein PMID: 22356826
    2. Aurora-A protein increased in stomach cancer cells in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin. PMID: 21932983
    3. Results describe the identification of a novel negative regulator of Aurora-A, named AIP (Aurora-A kinase Interacting Protein). PMID: 12244051
    4. Phe31Ile polymorphism in Aurora A may be a genetic modifier for developing breast carcinoma. PMID: 15271856
    5. We propose that AURKAIP1 might function upstream of the Az1 by enhancing the binding affinity of Az1 to Aurora-A to promote recognition, targeting to proteasome and subsequent degradation. PMID: 17452972
    6. AKURA phosphorylation of AIP and stabilization of the enzyme-substrate complex are reported. PMID: 17957726
    7. GSK-3beta modulates the early mitotic Aurora-A level through binding and phosphorylating AIP. PMID: 18391981
    8. Plk1 controls Aurora A localization and function by regulating cellular levels of hBora. PMID: 18521620
    9. Aurora A is necessary for the maintenance of the mitotic delay induced in response to microtubule-perturbing agents. PMID: 19221504

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  • 亞細胞定位：
    Mitochondrion. Nucleus.
  • 蛋白家族：
    Mitochondrion-specific ribosomal protein mS38 family
  • 組織特異性：
    Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24114

    OMIM: 609183

    KEGG: hsa:54998

    STRING: 9606.ENSP00000319778

    UniGene: Hs.632515



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