在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATXN10 Antibody

  • 中文名稱:
    ATXN10兔多克隆抗體
  • 貨號:
    CSB-PA883357ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: ATXN10 antibody at 4.79µg/ml
      Lane 1: A431 whole cell lysate
      Lane 2: LO2 whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Lane 4: 293T whole cell lysate
      Lane 5: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 54, 47 kDa
      Observed band size: 54 kDa
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA883357ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA883357ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATXN10 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATXN10
  • 別名:
    Ataxin 10 antibody; Ataxin-10 antibody; ATX10_HUMAN antibody; Atxn10 antibody; Brain protein E46 homolog antibody; E46L antibody; FLJ37990 antibody; HUMEEP antibody; Like mouse brain protein E46 antibody; OTTHUMP00000197383 antibody; SCA10 antibody; Spinocerebellar ataxia 10 antibody; Spinocerebellar ataxia type 10 protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Ataxin-10 protein (346-475AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
  • 基因功能參考文獻:
    1. The 19-CGGC-14 shared haplotype was found in 47% of Brazilian and in 63% of Peruvian families. Frequencies from both are statistically different from Brazilian controls but not Quechua controls. The most frequent haplotype in Quechuas, 19-15-CGGC-14-10, is found in 50% of Brazilian and in 65% of Peruvian patients. The ATTCT expansion may have arisen in a Native American chromosome. PMID: 28905220
    2. Polymorphism in ATXN10 gene is associated with spinocerebellar ataxia type 10. PMID: 28542277
    3. Inheritance patterns of ATCCT repeat interruptions in spinocerebellar ataxia type 10 expansions of ataxin-10 has been reported. PMID: 28423040
    4. Single molecule real time sequencing of long tandem nucleotide repeats in spinocerebellar ataxia ATXN10 reveals unique insight of repeat expansion structure in three unrelated patients. PMID: 26295943
    5. This is the first description of a family with two SCA mutations with affected subjects having a combined SCA2 and SCA10 phenotype. PMID: 25630585
    6. Inhibition of Aurora B or expression of the S12A mutant renders reduced interaction between Ataxin-10 and polo-like kinase 1 (Plk1), a kinase previously identified to regulate Ataxin-10 in cytokinesis. PMID: 25666058
    7. Data suggest precursor mRNA for SCA10 (crystalized using two model AUUCU SCA10 repeats) exhibits the following conformation: the two asymmetric RNA molecules are antiparallel to each other and the interaction is stabilized by multiple hydrogen bonds. PMID: 26039897
    8. the presence of repeat interruptions in SCA10 repeat expansion may have a role in epilepsy phenotype PMID: 24318420
    9. The SCA10 pentanucleotide repeat expansion was not found among a group of Cypriot ataxia patients. All had 10-19 ATTCT repeats. Controls had 11-20 repeats, with 14 being the most common number. PMID: 23026538
    10. Plk1 phosphorylates Ataxin-10 on Ser 77 and Thr 82. PMID: 21857149
    11. The expansion of the attct repeat in intron 9 of atxn10 is may caused Spinocerebellar ataxia type 10. PMID: 21827910
    12. Network building strategy led to the proposal of candidates for new ciliopathy disease genes, leading to the identification of the first human mutations in the Nephronophthisis gene Ataxin10 (ATXN10) and Joubert syndrome gene Tectonic2 (TCTN2). PMID: 21565611
    13. suggesting that the loss of function of hnRNP K plays a key role in cell death of SCA10. PMID: 20548952
    14. Data suggest that SCA10 could be related to chromatin structure abnormalities caused by the expansion and not to an abnormal or abnormally expressed ATXN10. PMID: 19936807
    15. frequency of SCA10 in spinocerebellar ataxia in France PMID: 11891842
    16. Interruptions in the expanded ATTCT repeat of spinocerebellar ataxia type 10 suggest that the purity of the expanded repeat element may be a disease modifier. PMID: 16385455
    17. These results implicate replication origin activity as one molecular mechanism associated with the instability of ataxin 10(ATTCT)n tracts that are longer than normal length. PMID: 17846122
    18. cause Spinocerebellar ataxia type 10 by expansion of the ATTCT pentanucleotide repeat in intron 9 of the gene PMID: 18386626
    19. The normal reference standard for ATXN10 gene's ATTCT pentanucleotide repeat of 9-32 is verified in the Chinese Han group. PMID: 19147916
    20. Nucleosome formation on pure and interrupted ATTCT pentanucleotides associated with spinocerebellar ataxia type 10 (SCA10), is reported. PMID: 19171184
    21. evidence for an ancestral common origin for SCA10 in Latin America, which might have arisen in an ancestral Amerindian population and later have been spread into the mixed populations of Mexico and Brazil. PMID: 19234597
    22. Ataxin 10 and eukaryotic initiation factors interacts with M2 protein of influenza A virus. PMID: 19835171

    顯示更多

    收起更多

  • 相關疾病:
    Spinocerebellar ataxia 10 (SCA10)
  • 亞細胞定位:
    Cytoplasm, perinuclear region.
  • 蛋白家族:
    Ataxin-10 family
  • 組織特異性:
    Expressed in the central nervous system.
  • 數據庫鏈接:

    HGNC: 10549

    OMIM: 603516

    KEGG: hsa:25814

    STRING: 9606.ENSP00000252934

    UniGene: Hs.475125



主站蜘蛛池模板: 色综合久久久无码中文字幕波多| 黑人强伦姧人妻久久| 四虎国产精品永久地址49| 开心五月激情综合婷婷色| 男女性爽大片视频| 麻豆国产精品va在线观看| 亚洲h成年动漫在线观看网站| 人人爽久久久噜噜噜婷婷| 99精品国产综合久久久久五月天| 国产佗精品一区二区三区| 少妇无码一区二区二三区| 亚洲国产精品嫩草影院永久| 激情av无码后入| 在线亚洲人成电影网站色www| 狠狠色综合7777久夜色撩人| 日产日韩亚洲欧美综合下载| 最新国产精品久久精品| 亚洲精品久久久久久中文传媒| 国产真人无遮挡作爱免费视频| 又色又爽又黄的gif动态图| 秋霞国产精品一区二区| 亚洲欧美色中文字幕在线| 久久久亚洲欧洲日产国产成人无码| 国内揄拍国内精品对白| 国内自拍久久久久影院| 国产精品国产三级国产专区53| 久久久久无码中| 又爽又黄又无遮挡网站| 国产 国语对白 露脸| 女人爽到高潮免费视频大全| 欧美性猛交xxx嘿人猛交| 亚洲精品午夜久久久伊人| 亚洲日韩av在线观看| 国内精品卡一卡二卡三| 99在线 | 亚洲| 99er热精品视频| 麻豆人妻少妇精品无码专区| 色伊人亚洲综合网站| 国产无遮挡a片又黄又爽漫画| 亚洲欧美国产精品久久| 狠狠色噜噜狠狠色综合久|