在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATRIP Antibody

  • 中文名稱:
    ATRIP兔多克隆抗體
  • 貨號:
    CSB-PA060306
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ATRIP
  • 別名:
    AGS1 antibody; ATIP antibody; ATM and Rad3 related interacting protein antibody; ATM and Rad3-related-interacting protein antibody; ATR interacting protein antibody; ATR-interacting protein antibody; Atrip antibody; ATRIP_HUMAN antibody; DKFZp762J2115 antibody; FLJ12343 antibody; MGC20625 antibody; MGC21482 antibody; MGC26740 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from Human ATRIP around the non-phosphorylation site of S224.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein.
  • 基因功能參考文獻:
    1. ATRIP deacetylation by SIRT2 promotes ATR-ATRIP binding to replication protein A-single-stranded DNA to drive ATR activation and thus facilitate recovery from replication stress. PMID: 26854234
    2. ATRIP SUMOylation promotes ATR activation by providing a unique type of protein glue that boosts multiple protein interactions along the ATR pathway PMID: 24990965
    3. Data on crystal structure of BRCA1 binding with phosphopeptides suggest that C-terminal domain of BRCA1 interacts with ATRIP and BAAT1 with preferences for specific side chains; in ATRIP, phospho-Ser239 and Phe242 are the main interacting residues. PMID: 24073851
    4. Data indicate that ATRIP is a direct target gene of HIF-1, and the increased ATRIP then activates the ATR signaling pathway under hypoxia. PMID: 23454212
    5. our analysis exposes an overlapping clinical manifestation between the disorders but allows an expanded spectrum of clinical features for ATR-ATRIP Seckel Syndrome to be defined PMID: 23144622
    6. as an ATR-associated kinase, Nek1 enhances the stability and activity of ATR-ATRIP before DNA damage, priming ATR-ATRIP for a robust DNA damage response PMID: 23345434
    7. ATRIP may function outside the context of the canonical ATR damage signaling pathway during HSV-1 infection to participate in the viral life cycle. PMID: 20861269
    8. data suggest that RPA-coated ssDNA is the critical structure at sites of DNA damage that recruits the ATR-ATRIP complex and facilitates its recognition of substrates for phosphorylation and the initiation of checkpoint signaling PMID: 12791985
    9. there are at least two in vitro ATR-ATRIP DNA binding complexes, one which binds DNA with high affinity in an RPA-dependent manner and a second, which binds DNA with lower affinity in an RPA-independent manner PMID: 14724280
    10. Collectively, our results suggest that the ATR-mediated phosphorylation of ATRIP at Ser-68 and -72 is dispensable for the initial response to DNA damage. PMID: 15451423
    11. N-terminal domain of the ATRIP protein contributes to the cell cycle checkpoint by regulating the intranuclear localization of ATR PMID: 15527801
    12. ATRIP is required for ATR accumulation at intranuclear foci induced by DNA damage. PMID: 15743907
    13. ATRIP oligomerization is essential for the function of the ATM and Rad3-related (ATR)-ATRIP complex, which exists in higher order oligomeric states within cells PMID: 16027118
    14. The expression of dimerization-defective ATRIP diminishes the maintenance of replication forks during treatment with DNA replication inhibitors. PMID: 16176973
    15. support the idea of a multistep model for ATR activation that requires separable localization and activation functions of ATRIP PMID: 17339343
    16. a direct physical interaction between BRCA1 and ATRIP is required for the checkpoint function of ATR PMID: 17616665
    17. ATRIP is a CDK2 substrate, and CDK2-dependent phosphorylation of S224 regulates the ability of ATR-ATRIP to promote cell cycle arrest in response to DNA damage PMID: 17638878

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Redistributes to discrete nuclear foci upon DNA damage.
  • 蛋白家族:
    ATRIP family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 33499

    OMIM: 606605

    KEGG: hsa:84126

    STRING: 9606.ENSP00000323099

    UniGene: Hs.694840



主站蜘蛛池模板: 少妇熟女久久综合网色欲| 人与禽交av在线播放| 日本肉体xxxx裸体137大胆| 欧美一性一乱一交一视频| 亚洲综合av一区二区三区不卡| 国产av福利久久| 亚洲国产福利一区二区三区| 5个黑人躁我一个视频| 国产大屁股视频免费区| 亚洲色成人四虎在线观看| 国产成_人_综合_亚洲_国产| 久久久国产打桩机| 精品人妻无码一区二区三区| 韩国19禁主播深夜福利视频| 人妻精品动漫h无码中字| 欧美三级韩国三级日本三斤| 亚洲欧美日韩综合在线一| 国内精品久久久久久久影视麻豆| 国产又色又爽又黄的免费| 国产av仑乱内谢| 国产成人精品日本亚洲一区| 国产下药迷倒白嫩美女网站| 久久久久亚洲精品| 国产精品久久久久久久久动漫| 亚洲日韩乱码中文字幕| 亚洲欧洲无码av一区二区三区 | 337p日本欧洲亚洲大胆裸体艺术| 免费夜色污私人影院在线观看| 人妻系列无码专区喂奶| 性饥渴少妇av无码毛片| 女人被男人爽到呻吟的视频| 午夜私人成年影院| 天堂久久天堂av色综合| 国产人妻一区二区三区四区五区六| 青青青伊人色综合久久| 国产日韩另类综合11页| 97免费人妻在线视频| 国产麻豆天美果冻无码视频| 国产精品亚洲а∨无码播放| 大ji巴好深好爽又大又粗视频| 国产亚av手机在线观看|