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ATP6V0A2 Antibody

  • 中文名稱:
    ATP6V0A2兔多克隆抗體
  • 貨號:
    CSB-PA897489LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescent analysis of A431 cells using CSB-PA897489LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) ATP6V0A2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    a2 antibody; A2V ATPase antibody; ARCL antibody; ATP6a2 antibody; ATP6N1D antibody; ATP6V0A2 antibody; ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 antibody; ATPase, H+ transporting, lysosomal V0 subunit a2 antibody; Infantile malignant osteopetrosis antibody; J6B7 antibody; Lysosomal H(+) transporting ATPase V0 subunit a2 antibody; Lysosomal H(+)-transporting ATPase V0 subunit a2 antibody; regeneration and tolerance factor antibody; Stv1 antibody; TJ6 antibody; TJ6M antibody; TJ6s antibody; V ATPase 116 kDa isoform a2 antibody; V type proton ATPase 116 kDa subunit a antibody; V type proton ATPase 116 kDa subunit a isoform 2 antibody; V-ATPase 116 kDa isoform a2 antibody; V-type proton ATPase 116 kDa subunit a isoform 2 antibody; Vacuolar proton translocating ATPase 116 kDa subunit a antibody; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 antibody; Vph1 antibody; VPP2_HUMAN antibody; WSS antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human V-type proton ATPase 116 kDa subunit a isoform 2 protein (476-549AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,ATP6V0A2 Antibody (CSB-PA897489LA01HU),的標(biāo)記方式是Non-conjugated。對于ATP6V0A2 Antibody,我們還提供其他標(biāo)記。見下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA897489LB01HU ATP6V0A2 Antibody, HRP conjugated ELISA
    FITC CSB-PA897489LC01HU ATP6V0A2 Antibody, FITC conjugated
    Biotin CSB-PA897489LD01HU ATP6V0A2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation.
  • 基因功能參考文獻(xiàn):
    1. Data suggest that missense mutations in ATP6V0A2 and ATP6V0A4 that cause either cutis laxa or distal renal tubular acidosis result in enzyme subunits that are unstable, retained in endoplasmic reticulum (rather than transported to Golgi and cell membrane), and quickly degraded by proteasomes despite full glycosylation. PMID: 29311258
    2. Study shows how tumor associated a2-isoform V-ATPase can induce neutrophil migration by stimulating autocrine secretion of IL-8, suggesting a mechanism for the creation of a level of inflammation that favors cancer growth. PMID: 27845385
    3. In cisplatin resistant cells, shRNA mediated inhibition of V-ATPase-V0a2 enhanced sensitivity towards both cisplatin and carboplatin. PMID: 26899534
    4. a2V deficiency disrupts the endolysosomal route in Notch and TGF signaling, thereby impairing mammary gland development. PMID: 27809299
    5. Senescence-associated impaired expression of ATP6V0A2 triggers changes in Golgi structure and glycosylation in old fibroblasts, which demonstrates a role of ATP6V0A2 in cellular senescence program. PMID: 26611489
    6. the results from this study demonstrate that the a2-subunit isoform of Vacuolar ATPase regulates Notch signaling in breast tumor cells PMID: 26418877
    7. The granule-associated a2V isoform has a role in maintaining a pH gradient within the cell between the cytosol and granules in neutrophils. PMID: 25877929
    8. Case Report: novel ATP6V0A2 mutations in an infant with cutis laxa. PMID: 24815019
    9. Expression of a2 vacuolar ATPase in spermatozoa is associated with semen quality and chemokine-cytokine profiles in infertile men. PMID: 23936208
    10. Mutations in the ATP6V0A2 gene is associated with autosomal recessive cutis laxa. PMID: 22773132
    11. A mechanism is described by which tumor-associated macrophages mature via a nontraditional cytokine-like signal, the a2NTD peptide. PMID: 21178005
    12. Data show that the V-ATPase a2-subunit might actually be embedded into and/or closely associated with membrane phospholipids even in the absence of any obvious predicted transmembrane segments. PMID: 20669186
    13. Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO. PMID: 20153292
    14. Studies indicate that mutations in the ATP6V0A2 gene were found in families with autosomal recessive cutis laxa. PMID: 19401719
    15. RTF (Regeneration and tolerance factor), the alpha-2 isoform of the alpha subunit of vacuolar ATPase, has a role in controlling IL-1 beta secretion by regulating P2X7 activity. PMID: 15301855
    16. cells were not susceptible to apoptosis when the 70-kDa RTF was present but were when the 50-kDa RTF was present; the increase in levels of the 50-kDa RTF on cells from HIV-positive individuals is important in preventing apoptosis PMID: 15358640
    17. RTF is constitutively expressed at endometrial and decidual level, and its up-regulation during the secretory phase of the cycle may be relevant in mediating some immune-related aspects of uterine physiology. PMID: 15373763
    18. Its role in organellar proton pumping suggests that hTJ6 function may participate in protein trafficking/processing. PMID: 16113235
    19. Data suggest a role for the N-terminus domain of the a2 isoform of vacuolar ATPase in the regulation of IL-1beta pro-inflammatory cytokine production at the fetal-maternal interface. PMID: 17295899
    20. Study identified loss-of-function mutations in ATP6V0A2, encoding the a2 subunit of the V-type H+ ATPase, in several families with autosomal recessive cutis laxa type II or wrinkly skin syndrome. PMID: 18157129
    21. the relationship between ATP6V0A2 mutations, the glycosylation defect and the autosomal recessive cutis laxa type II phenotype is discussed [review] PMID: 19171192
    22. Loss-of-function mutations in ATP6V0A2 lead to tropoelastin aggregation in the Golgi and increased apoptosis of elastogenic cells. PMID: 19321599

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  • 相關(guān)疾病:
    Cutis laxa, autosomal recessive, 2A (ARCL2A); Wrinkly skin syndrome (WSS)
  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Endosome membrane.
  • 蛋白家族:
    V-ATPase 116 kDa subunit family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18481

    OMIM: 219200

    KEGG: hsa:23545

    STRING: 9606.ENSP00000332247

    UniGene: Hs.25786



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