在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATP5F1A Antibody, FITC conjugated

  • 中文名稱:
    ATP5F1A兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA002344HC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATP5A1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ATP synthase alpha chain antibody; ATP synthase alpha chain; mitochondrial antibody; ATP synthase subunit alpha antibody; ATP synthase subunit alpha mitochondrial antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit 1; cardiac muscle antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; 1 antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 1; cardiac muscle antibody; ATP synthase; H+ transporting; mitochondrial F1 complex; alpha subunit; isoform 2; non-cardiac muscle-like 2 antibody; ATP sythase (F1 ATPase) alpha subunit antibody; ATP5A antibody; Atp5a1 antibody; ATP5AL2 antibody; ATPA_HUMAN antibody; ATPM antibody; Epididymis secretory sperm binding protein Li 123m antibody; hATP1 antibody; HEL-S-123m antibody; MC5DN4 antibody; mitochondrial antibody; Mitochondrial ATP synthetase antibody; Mitochondrial ATP synthetase oligomycin resistant antibody; Modifier of Min 2 antibody; Modifier of Min 2 mouse homolog antibody; Modifier of Min 2; mouse; homolog of antibody; MOM2 antibody; OMR antibody; ORM antibody; OTTHUMP00000163475 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human ATP synthase subunit alpha, mitochondrial protein (59-257AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions.
  • 基因功能參考文獻:
    1. Using systems biology techniques to study gene coexpression network, ATP5A1 was identified and found highly expressed in normal kidney than clear cell renal cell carcinoma (ccRCC) tissues of each grade. Functional and pathway enrichment analysis demonstrated that ATP5A1 is overrepresented in pathway of oxidative phosphorylation, which associated with tumorigenesis and tumor progression. PMID: 29207195
    2. This cohort study showed that the ATP5A1 gene was down regulation between patients with idiopathic Parkinson disease and controls PMID: 28916538
    3. these data highlight a key role of the P2Y1/PI3Kbeta axis in endothelial cell proliferation downstream of ecto-F1-ATPase activation by apoA-I. Pharmacological targeting of this pathway could represent a promising approach to enhance vascular endothelial protection. PMID: 28578353
    4. These findings, together with the previously reported inhibition of respiratory complex I, show that depression of the activity of oxidative phosphorylation enzymes is involved in the cell growth inhibitory action of ATRA. PMID: 27856255
    5. High mRNA levels of ATP5A1 are associated with glioblastoma. PMID: 26526033
    6. Hemoglobin - a novel ligand of hepatocyte ectopic F1-ATPase PMID: 26769832
    7. Here, we found that ATP synthase subunit alpha (ATP5A) was O-GlcNAcylated at Thr432 and ATP5A O-GlcNAcylation was decreased in the brains of AD patients and transgenic mouse model PMID: 26358770
    8. Mitochondrial calpain-1 disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia. PMID: 26246018
    9. Studies indicate that the F-ATP synthase can reversibly undergo a Ca(2+)-dependent transition to form a channel that mediates the permeability transition. PMID: 25999424
    10. A mutation in ATP5A1 causes a fatal neonatal mitochondrial encephalopathy. PMID: 23599390
    11. Studies indicate that F1-ATPase (F1) is a rotary motor protein driven by ATP hydrolysis and the minimum complex of F1 for function as a rotary motor is the alpha3beta3gamma subcomplex. PMID: 23395605
    12. Homozygous mutations in this gene are the likely cause of mitochondrial disease in two sisters, with support from a yeast model. PMID: 23596069
    13. F1-ATPase at the cell surface of colonic epithelial cells has a role in mediating cell proliferation PMID: 23055519
    14. An interactive proteomics study was done to examine proteins that bind heterocomplexes with ABCC1 using coimmunoprecipitation and MS/MS analyses. We found that ATP synthase alpha binds to ABCC1 in plasma membranes with a ratio of 2:1. PMID: 22188235
    15. Antibodies to the beta- and gamma-subunits of F(1)-ATPase are further antimitochondrial antibodies in primary biliary cirrhosis. PMID: 22098431
    16. A selective Cys in ATP synthase alpha subunit is targeted by multiple oxidative posttranslational modifications suggesting that this Cys residue may act as a redox sensor modulating ATP synthase function. PMID: 21817160
    17. Data suggest that F1-ATPase catalytic site show the correlation between the phosphate binding and the tightening of the alphabeta-interface. PMID: 21481781
    18. This protein has been found differentially expressed in the anterior cingulate cortex in men patients with schizophrenia. PMID: 20381070
    19. The alpha-chain of ATP synthase is implicated in neurofibrillary degeneration of Alzheimer's disease that is illustrated by the cytosolic accumulation of this mitochondrial protein, which belongs to the mitochondrial respiratory system. PMID: 12614671
    20. Within the structurally-confined internal aqueous cavity of the F1-motor of ATP synthase, function results from free energy changes that shift the balance between interfacial charge hydration and interfacial hydrophobic hydration. PMID: 16378738
    21. analysis of vascular endothelial ectoadenylate kinase and plasma membrane ATP synthase PMID: 16714292
    22. Higher levels of ATP5a1 expression are associated with certain Single Nucleotide Polymorphisms and with TP53 mutation. PMID: 19261598
    23. These data show that an linoleic acid-phospholipid induced stimulation in hepatic HDL secretion is related to the expression and function of membrane ATP metabolizing proteins. PMID: 19717637
    24. This protein has been found differentially expressed in the Wernicke's Area from patients with schizophrenia. PMID: 19405953
    25. This protein has been found differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. PMID: 19110265

    顯示更多

    收起更多

  • 相關疾病:
    Combined oxidative phosphorylation deficiency 22 (COXPD22); Mitochondrial complex V deficiency, nuclear 4 (MC5DN4)
  • 亞細胞定位:
    Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein; Matrix side. Cell membrane; Peripheral membrane protein; Extracellular side.
  • 蛋白家族:
    ATPase alpha/beta chains family
  • 組織特異性:
    Fetal lung, heart, liver, gut and kidney. Expressed at higher levels in the fetal brain, retina and spinal cord.
  • 數據庫鏈接:

    HGNC: 823

    OMIM: 164360

    KEGG: hsa:498

    STRING: 9606.ENSP00000282050

    UniGene: Hs.298280



主站蜘蛛池模板: 日本一区二区更新不卡| 国产亚洲高清国产拍精品| 男女裸交免费无遮挡全过程| 毛茸茸性xxxx毛茸茸毛茸茸| 最新永久无码av网址亚洲| 中国农村妇女真实bbwbbwbbw | 狠狠色狠狠色五月激情| 国产精品亚洲二区在线看| 人妻熟妇乱又伦精品hd| 欧美男男大粗吊1069| 国产中文字字幕乱码无限| 北条麻妃一区二区三区av高清| 黄在线看片免费人成视频| 婷婷色综合视频在线观看| 中文字幕av无码一二三区电影 | 日韩免费无码人妻波多野| 国产成人av在线一区二区三区 | 久久日本三级韩国三级| 国产成人美女裸体片免费看| 日本熟妇厨房bbw| 少妇一边呻吟一边说使劲视频 | 欧美日韩免费专区在线| 乱子伦av无码中文字| 免费无码国产欧美久久18| 国产人妖xxxx做受视频| 久久综合九色综合欧美狠狠| 娜娜麻豆国产电影| 国产9 9在线 | 欧洲| 无码成人一区二区三区| 九九视频在线观看视频6| 欧美日韩精品suv| 国内精品久久久久影院亚瑟| 国产又色又爽又高潮免费| 和岳每晚弄的高潮嗷嗷叫视频| 国产揄拍国产精品| 乌克兰性欧美精品高清| 大屁股熟女一区二区三区| 亚洲精品成人无码中文毛片不卡| 丝袜无码一区二区三区| 日本亚欧热亚洲乱色视频| 永久免费无码av网站在线观看|