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  4. ATP2B3 Antibody

ATP2B3 Antibody

  • 中文名稱：
    ATP2B3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA613698LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate
      All lanes: ATP2B3 antibody at 1:500
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 135, 129, 128, 133, 127, 125, 123 kDa
      Observed band size: 135 kDa
    • Immunofluorescence staining of Hela cells with CSB-PA613698LA01HU at 1:33, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ATP2B3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ATP2B3Plasma membrane calcium-transporting ATPase 3 antibody; PMCA3 antibody; EC 7.2.2.10 antibody; Plasma membrane calcium ATPase isoform 3 antibody; Plasma membrane calcium pump isoform 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Plasma membrane calcium-transporting ATPase 3 protein (1057-1220AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁(yè)面中的產(chǎn)品，ATP2B3 Antibody (CSB-PA613698LA01HU)，的標(biāo)記方式是Non-conjugated。對(duì)于ATP2B3 Antibody，我們還提供其他標(biāo)記。見(jiàn)下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA613698LB01HU ATP2B3 Antibody, HRP conjugated ELISA
    FITC CSB-PA613698LC01HU ATP2B3 Antibody, FITC conjugated
    Biotin CSB-PA613698LD01HU ATP2B3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:100-1:1000
    IF 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established.
  • 基因功能參考文獻(xiàn)：
    1. Authors report a novel PMCA3 mutation (G733R substitution) in the catalytic P-domain of the pump in a patient affected by non-progressive ataxia, muscular hypotonia, dysmetria and nystagmus. PMID: 28807751
    2. The ataxia related G1107D mutation of the PMCA 3 impairs its calcium pumping function. The mutation affects the interplay of calmodulin with its binding domain on the pump, decreasing its stimulation. PMID: 27632770
    3. In summary, the APA-associated ATP2B3(Leu425_Val426del) mutant promotes aldosterone production by at least 2 different mechanisms: 1) a reduced Ca(2+) export due to the loss of the physiological pump function; and 2) an increased Ca(2+) influx due to opening of depolarization-activated Ca(2+) channels as well as a possible Ca(2+) leak through the mutated pump. PMID: 27035656
    4. Mutations in ATP2B3 gene is associated with aldosterone-producing adenomas. PMID: 26285814
    5. Novel PMCA3 missense mutation co-occurring with a heterozygous mutation in LAMA1 impaired cellular Ca2+ homeostasis in patients with Cerebellar Ataxia. PMID: 25953895
    6. ATP2B3 mutations are present in aldosterone-producineg adenomas that result in an increase in CYP11B2 gene expression and may account for the dysregulated aldosterone production in a subset of patients with sporadic primary aldosteronism. PMID: 24082052
    7. Somatic mutations in ATP2B3 gene leads to aldosterone-producing adenomas and secondary hypertension. PMID: 23416519
    8. Mutation of plasma membrane Ca2+ ATPase isoform 3 in a family with X-linked congenital cerebellar ataxia impairs Ca2+ homeostasis. PMID: 22912398
    9. Expression of the placental calcium transporter PMCA3 mRNA predicts neonatal whole body bone mineral content PMID: 17336174

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  • 相關(guān)疾病：
    Spinocerebellar ataxia, X-linked 1 (SCAX1)
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIB subfamily
  • 組織特異性：
    Highly expressed in the cerebellum. Expressed in adrenal glands.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 816

    OMIM: 300014

    KEGG: hsa:492

    STRING: 9606.ENSP00000263519

    UniGene: Hs.533956



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