在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATP1B1 Antibody, FITC conjugated

  • 中文名稱:
    ATP1B1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA002326LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATP1B1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ATP1B1; ATP1B; Sodium/potassium-transporting ATPase subunit beta-1; Sodium/potassium-dependent ATPase subunit beta-1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Sodium/potassium-transporting ATPase subunit beta-1 protein (64-241AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane.; Involved in cell adhesion and establishing epithelial cell polarity.
  • 基因功能參考文獻:
    1. Novel Single Nucleotide Polymorphism at ATP1B1 implicate gene regulatory dysfunction in QT prolongation in African and Hispanic Americans. PMID: 27988371
    2. the ratio between FXYD5 and alpha1-beta1 heterodimer determines whether the Na,K-ATPase acts as a positive or negative regulator of intercellular adhesion. PMID: 27142834
    3. Our study describes the potent inhibition of Chikungunya virus and related alphaviruses by the cardiac glycoside digoxin and demonstrates a function for the sodium-potassium ATPase in Chikungunya virus infection. PMID: 27222471
    4. Expression of miR-26a and miR-29a was significantly down regulated in leukoplakia and cancer tissues but up regulated in lichen planus tissues. Expression of target genes such as, ADAMTS7, ATP1B1, COL4A2, CPEB3, CDK6, DNMT3a and PI3KR1 was significantly down regulated in at least two of three disease types with respect to normal tissues. PMID: 27515006
    5. Overexpression of ATP1B1 is associated with cytogenetically normal acute myeloid leukemia. PMID: 26506237
    6. Na,K-ATPase b1-subunit is a target of the Shh signaling pathway and loss of b1-subunit expression may contribute to tumor development and progression not only in carcinoma but also in medulloblastoma, a tumor of neuronal origin. PMID: 26286140
    7. Impaired regulation and compromised activity of ion channel proteins contribute to the pathophysiology of vascular dementia. PMID: 25152327
    8. Activities of AE1 and the sodium pump are coregulated in kidney. PMID: 25012180
    9. ATP1B1 is epigenetically silenced by promoter methylation in both renal cell carcinoma (RCC) patients' tissues and cell lines. PMID: 24452105
    10. A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure. PMID: 24098465
    11. Changes were found in mRNA and protein expressions of Na(+)/K(+)-ATPase subunits in LG from term pregnant rabbits and these changes suggest a role in the pregnancy-related LG secretion changes and dry eye symptoms observed in these animals. PMID: 23009595
    12. Data show that protein kinase A (PKA) phosphorylation has a drastic impact on Na(+)/K(+)-ATPase (NKA) structure and dynamics PMID: 22433860
    13. examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans PMID: 21881522
    14. interactions between the beta subunits of neighboring cells maintain integrity of intercellular junctions PMID: 21642423
    15. Na(+)-K(+) ATPase B1 can synergize with adriamycin and reverse drug resistance in MCF7 cells. PMID: 19664334
    16. Silencing of ATP1B1 gene can enhance the proliferation and migration capability of SGC-7901 adenocarcinoma cells. PMID: 19619434
    17. through its interaction with ATP1B1, MLC1 is involved in the control of intracellular osmotic conditions and volume regulation in astrocytes, opening new perspectives for understanding the pathological mechanisms of MLC disease. PMID: 20926452
    18. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway. PMID: 21085665
    19. Results identified that the beta1 subunit of the host Na(+)/K(+)-ATPase beta1 subunit (ATP1B1) interacts with the cytoplasmic domain of both the influenza A and B virus M2 and BM2 proteins. PMID: 21104370
    20. Data show that deglycosylation in polarized hepatic cells by drugs, or by site-directed mutagenesis of the N-linked-glycosylation residues, cause the Na+/K+-ATPase beta-subunit to traffic from the native basolateral to the apical/canalicular domain. PMID: 16339171
    21. these studies are indicative of a synergism between Sp1 and CREB in mediating regulation of Na-K ATPase beta1 subunit by PGRE3; while regulation occurring through PGRE1 also involves Sp1 and CREB. PMID: 16478973
    22. Study identifies an interaction between Wolframin and Na+/K+ ATPase beta1 subunit in transfected Cos7 cells, and between endogenous proteins in placental, neuroblastoma and MIN6 pancreatic beta-cell lines. PMID: 17947299
    23. E2A and Na/K-ATPase beta1 subunit expression in epithelial cells are regulated by interactions between these proteins. PMID: 18727914
    24. Reduced expression of the Na,K-beta(1) protein is associated with oxaliplatin resistance in cancer cells. PMID: 19322565
    25. Propose that kinase-dependent regulation of the Na(+)-K(+) pump occurs via glutathionylation of its beta(1) subunit (ATP1B1) at Cys46. PMID: 19542013
    26. ATP1B1 may confer susceptibility to BP regulation and hypertension in this Chinese population. PMID: 19563793
    27. Measured properties of the purified carboxy-terminal lobe suggest that the fragment is correctly folded and compatible with the proposed model of Na,K-ATPase beta1 subunit. PMID: 19694409
    28. Genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 19305409

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Cell membrane, sarcolemma.
  • 蛋白家族:
    X(+)/potassium ATPases subunit beta family
  • 組織特異性:
    Found in most tissues.
  • 數據庫鏈接:

    HGNC: 804

    OMIM: 182330

    KEGG: hsa:481

    STRING: 9606.ENSP00000356789

    UniGene: Hs.291196



主站蜘蛛池模板: 日韩免费无码人妻波多野| 日本大片免a费观看视频三区| 国产大屁股视频免费区| 97国语精品自产拍在线观看| 中文字幕制服丝袜第57页| 国产成人无码av一区二区在线观看| 免费无码av片在线观看播放| 久久 国产 尿 小便 嘘嘘| 亚洲欧美日韩综合久久| 开心色怡人综合网站| 2021久久国自产拍精品| 大又大粗又爽又黄少妇毛片| 国产xxxxx在线观看| 成人午夜福利院在线观看| 亚洲午夜无码久久久久软件| 免费毛片全部不收费的| 国产精品-区区久久久狼| 欧美性狂猛xxxxx深喉| 久久www免费人成_看片老司机| 日日摸天天爽天天爽视频| 高h猛烈失禁潮喷无码视频| 免费现黄频在线观看国产| 亚洲精品网站在线观看你懂的 | 久久午夜无码鲁丝片| 超碰97人人射妻| 一本之道高清乱码久久久| 中文字幕免费无码专区| 国产裸拍裸体视频在线观看| 天堂中文8资源在线8| 无码中文人妻在线三区| 又粗又大又硬毛片免费看| 影音先锋女人aa鲁色资源| 亚洲国产高清av网站| 无码三级中文字幕在线观看| 精品乱子伦一区二区三区| 自愉自愉产区二十四区| 天天狠天天透天干天天| 夫妻免费无码v看片| 亚洲国产精品久久久久爰色欲| 中国农村妇女真实bbwbbwbbw| 亚洲精品揄拍自拍首页一|