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ATN1 Antibody

  • 中文名稱:
    ATN1兔多克隆抗體
  • 貨號:
    CSB-PA048957
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, A549 cells, K562 cells, COLO205 cells and NIH-3T3 cells, using ATN1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATN1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human ATN1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
  • 基因功能參考文獻:
    1. Data indicate that the size of the expanded CAG repeats od dentatorubral-pallidoluysian atrophy protein (DRPLA) was inversely correlated with the age at onset. PMID: 27577205
    2. Epigenetic regulation of ATN1 by LSD1 is required for cortical progenitor maintenance. PMID: 25519973
    3. Juvenile myoclonic epilepsy is not associated with the DRPLA gene in a European population. PMID: 25398822
    4. These data demonstrate that the expanded trinucleotide repeat within ATN-1 mRNA is a potential target for compounds designed to achieve allele-selective inhibition of ATN-1 protein, and one agent may allow the targeting of multiple disease genes. PMID: 24981774
    5. results suggest that expanded polyQ repeats in ATN1 may contribute to neurodegeneration via alterations in both protein aggregation and intracellular localization. PMID: 23933208
    6. This study demonistrated that hypoalbuminemia in early onset DRPLA revealed the possibility of multiorgan involvement. PMID: 23263592
    7. In cerebrum and cerebellum of DRPLA transgenic mouse lines at 4, 8, and 12 weeks it is demonstrated that both the number and expression levels of the altered genes are highly dependent on CAG repeat length and age in both brain regions. PMID: 22342974
    8. This study demonistrated that Atn1 is response for Dentatorubral-pallidoluysian atrophy. PMID: 22083836
    9. A pair of monozygotic twins is diagnosed with dentatorubro pallidoluysian atrophy, identical CAG repeats, and different clinical courses. PMID: 21749564
    10. This sttudy suggested that age-dependent and CAG repeat-dependent intranuclear accumulation of mutant DRPLA leading to nuclear dysfunctions are suggested to be the essential pathophysiologic mechanisms in Dentatorubral-pallidoluysian atrophy. PMID: 21827919
    11. Atrophin-1 promote neurodegeneration with autophagic hallmarks both in neuronal photoreceptors and glial cells. PMID: 20339376
    12. the C-terminal fragment plays a principal role in the pathological accumulation of ATN1 in dentatorubral-pallidoluysian atrophy PMID: 20977674
    13. The CAG repeat length of DRPLA may have a considerable effect on not only the disease onset but also the disease milestones and prognosis in DRPLA patients. PMID: 20589872
    14. Molecular testing for dentatorubral pallidoluysian atrophy revealed abnormal "cytosine-adenine-guanosine" expansion in the atrophin-1 gene. PMID: 20196398
    15. Nuclear localization of a non-caspase truncation product of this protein, with an expanded polyglutamine repeat, increases cellular toxicity. PMID: 12464607
    16. DRPLA protein is a phosphoprotein, and c-Jun NH(2)-terminal kinase (JNK) is one of the major factors involved in its phosphorylation PMID: 12812981
    17. The molecular architecture of CAG repeats in mutant DRPLA was studied. PMID: 15223312
    18. In DRPLA, the expression ratio of two mRNA isoforms was generated by alternative splicing. The glutamine-included protein isoform was more predominantly localized in the cell nucleus. PMID: 16091834
    19. mutant atropphin with polyglutamine expansion does not simply function in a dominant negative manner PMID: 16407196
    20. Status epilepticus during sleep caused by an expansion of the CAG repeat in the DRPLA gene. PMID: 16534126
    21. linkage and association for three CAG triplet repeat markers (Spinocerebellar Ataxia Type 1, SCA1; Machado-Joseph Disease, MJD; Dentatorubro-pallidoluysian Atrophy, DRPLA) to assess their contribution to variation in cognitive ability PMID: 16967484
    22. Both Drosophila and human Brakeless and Atrophin interact in vitro. Brakeless homologs may influence the toxicity of polyglutamine-expanded Atrophin-1. PMID: 17503969
    23. data suggest that a founder effect accounts for some of the high prevalence of Dentatorubral pallidoluysian and ATN1 expansion polymorphism in Wales. PMID: 17965145
    24. 244 Patients with the diagnosis of Huntington's Disease and without mutation of the IT15 gene revealed one case of SCA17 but did not disclose the presence of two other diseases with a similar clinical manifestation: DRPLA and HDL2. PMID: 18651325
    25. The dentatorubral-pallidoluysian atrophy transgenic mice showed severe neurological phenotypes with progressive brain atrophy and premature death. PMID: 19039037

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  • 相關疾病:
    Dentatorubral-pallidoluysian atrophy (DRPLA)
  • 亞細胞定位:
    Nucleus. Cytoplasm, perinuclear region. Cell junction.
  • 組織特異性:
    Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus
  • 數據庫鏈接:

    HGNC: 3033

    OMIM: 125370

    KEGG: hsa:1822

    STRING: 9606.ENSP00000349076

    UniGene: Hs.143766



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