在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATN1 Antibody

  • 中文名稱:
    ATN1兔多克隆抗體
  • 貨號:
    CSB-PA048957
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HeLa cells, A549 cells, K562 cells, COLO205 cells and NIH-3T3 cells, using ATN1 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATN1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATN1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from N-terminal of Human ATN1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats.
  • 基因功能參考文獻:
    1. Data indicate that the size of the expanded CAG repeats od dentatorubral-pallidoluysian atrophy protein (DRPLA) was inversely correlated with the age at onset. PMID: 27577205
    2. Epigenetic regulation of ATN1 by LSD1 is required for cortical progenitor maintenance. PMID: 25519973
    3. Juvenile myoclonic epilepsy is not associated with the DRPLA gene in a European population. PMID: 25398822
    4. These data demonstrate that the expanded trinucleotide repeat within ATN-1 mRNA is a potential target for compounds designed to achieve allele-selective inhibition of ATN-1 protein, and one agent may allow the targeting of multiple disease genes. PMID: 24981774
    5. results suggest that expanded polyQ repeats in ATN1 may contribute to neurodegeneration via alterations in both protein aggregation and intracellular localization. PMID: 23933208
    6. This study demonistrated that hypoalbuminemia in early onset DRPLA revealed the possibility of multiorgan involvement. PMID: 23263592
    7. In cerebrum and cerebellum of DRPLA transgenic mouse lines at 4, 8, and 12 weeks it is demonstrated that both the number and expression levels of the altered genes are highly dependent on CAG repeat length and age in both brain regions. PMID: 22342974
    8. This study demonistrated that Atn1 is response for Dentatorubral-pallidoluysian atrophy. PMID: 22083836
    9. A pair of monozygotic twins is diagnosed with dentatorubro pallidoluysian atrophy, identical CAG repeats, and different clinical courses. PMID: 21749564
    10. This sttudy suggested that age-dependent and CAG repeat-dependent intranuclear accumulation of mutant DRPLA leading to nuclear dysfunctions are suggested to be the essential pathophysiologic mechanisms in Dentatorubral-pallidoluysian atrophy. PMID: 21827919
    11. Atrophin-1 promote neurodegeneration with autophagic hallmarks both in neuronal photoreceptors and glial cells. PMID: 20339376
    12. the C-terminal fragment plays a principal role in the pathological accumulation of ATN1 in dentatorubral-pallidoluysian atrophy PMID: 20977674
    13. The CAG repeat length of DRPLA may have a considerable effect on not only the disease onset but also the disease milestones and prognosis in DRPLA patients. PMID: 20589872
    14. Molecular testing for dentatorubral pallidoluysian atrophy revealed abnormal "cytosine-adenine-guanosine" expansion in the atrophin-1 gene. PMID: 20196398
    15. Nuclear localization of a non-caspase truncation product of this protein, with an expanded polyglutamine repeat, increases cellular toxicity. PMID: 12464607
    16. DRPLA protein is a phosphoprotein, and c-Jun NH(2)-terminal kinase (JNK) is one of the major factors involved in its phosphorylation PMID: 12812981
    17. The molecular architecture of CAG repeats in mutant DRPLA was studied. PMID: 15223312
    18. In DRPLA, the expression ratio of two mRNA isoforms was generated by alternative splicing. The glutamine-included protein isoform was more predominantly localized in the cell nucleus. PMID: 16091834
    19. mutant atropphin with polyglutamine expansion does not simply function in a dominant negative manner PMID: 16407196
    20. Status epilepticus during sleep caused by an expansion of the CAG repeat in the DRPLA gene. PMID: 16534126
    21. linkage and association for three CAG triplet repeat markers (Spinocerebellar Ataxia Type 1, SCA1; Machado-Joseph Disease, MJD; Dentatorubro-pallidoluysian Atrophy, DRPLA) to assess their contribution to variation in cognitive ability PMID: 16967484
    22. Both Drosophila and human Brakeless and Atrophin interact in vitro. Brakeless homologs may influence the toxicity of polyglutamine-expanded Atrophin-1. PMID: 17503969
    23. data suggest that a founder effect accounts for some of the high prevalence of Dentatorubral pallidoluysian and ATN1 expansion polymorphism in Wales. PMID: 17965145
    24. 244 Patients with the diagnosis of Huntington's Disease and without mutation of the IT15 gene revealed one case of SCA17 but did not disclose the presence of two other diseases with a similar clinical manifestation: DRPLA and HDL2. PMID: 18651325
    25. The dentatorubral-pallidoluysian atrophy transgenic mice showed severe neurological phenotypes with progressive brain atrophy and premature death. PMID: 19039037

    顯示更多

    收起更多

  • 相關疾病:
    Dentatorubral-pallidoluysian atrophy (DRPLA)
  • 亞細胞定位:
    Nucleus. Cytoplasm, perinuclear region. Cell junction.
  • 組織特異性:
    Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus
  • 數據庫鏈接:

    HGNC: 3033

    OMIM: 125370

    KEGG: hsa:1822

    STRING: 9606.ENSP00000349076

    UniGene: Hs.143766



主站蜘蛛池模板: 色情久久久av熟女人妻网站| 国产又黄又爽又色的免费视频| 成年美女黄网站色大片免费看| 国产v亚洲v天堂无码久久久 | 久久精品国产精品亚洲下载| 亚洲制服有码在线丝袜| 最新在线精品国自产拍视频| 久久偷看各类wc女厕嘘嘘偷窃| 国产精品国产免费无码专区不卡| av无码免费岛国动作片片段欣赏网| 99久久超碰中文字幕伊人| 曰本av中文字幕一区二区| 无码av中文一区二区三区桃花岛| 亚洲高清有码中文字| 亚洲国产成人在人网站天堂| 国产亚洲产品影市在线产品| 中文字幕在线观看亚洲日韩| 曰本大码熟中文字幕| 亚洲人成色77777在线观看大战| 亚洲精品少妇30p| 伊人久久综合成人网| 国产综合视频一区二区三区| 人妻少妇乱子伦精品无码专区电影| 中文字幕日韩欧美一区二区三区| 亚洲日韩久热中文字幕| 欧美日本特级婬片视频| 亚洲中文字幕一区精品自拍| 日韩精品毛片无码一区到三区| 国产三级韩国三级日产三级| 狠狠做五月深爱婷婷伊人| 蜜臀久久99精品久久久久久| 综合久久国产九一剧情麻豆| √天堂资源中文| 色噜噜狠狠狠综合曰曰曰| 久久精品国产曰本波多野结衣| 日本黄漫动漫在线观看视频| 色中色成人导航| 久久久久久国产精品无码超碰| 久久亚洲精品无码gv| 亚洲va在线∨a天堂va欧美va | 国产精品久久久久久久久久久久午衣片|