在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATG4B Antibody

  • 中文名稱:
    ATG4B兔多克隆抗體
  • 貨號:
    CSB-PA529850
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muscle Tissue using ATG4b Rabbit pAb diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded Human Brain Tissue using ATG4b Rabbit pAb diluted at 1:200
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    APG4 autophagy 4 homolog B antibody; APG4B antibody; ATG4 autophagy related 4 homolog B (S. cerevisiae) antibody; ATG4B antibody; ATG4B_HUMAN antibody; AUT like 1 cysteine endopeptidase antibody; AUT-like 1 cysteine endopeptidase antibody; AUTL1 antibody; Autophagin 1 antibody; Autophagin-1 antibody; Autophagy related 4B cysteine peptidase antibody; Autophagy related cysteine endopeptidase 1 antibody; Autophagy related protein 4 homolog B antibody; Autophagy-related cysteine endopeptidase 1 antibody; Autophagy-related protein 4 homolog B antibody; Cysteine protease ATG4B antibody; hAPG4B antibody; MGC1353 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Recombinant Protein of ATG4b
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC IHC-p:1:50-200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.
  • 基因功能參考文獻:
    1. ATG4B expression was observed markedly upregulated by EWS-FLI1 overexpression, and silencing of ATG4B dramatically inhibits autophagy in Ewing sarcoma cells. PMID: 28902354
    2. study demonstrates that Rab7b regulates LC3 processing by modulating Atg4B activity; taken together, findings reveal Rab7b as a novel negative regulator of autophagy through its interaction with Atg4B PMID: 28835545
    3. ATG4B contains a C-terminal LIR motif important for binding and efficient cleavage of mammalian orthologs of yeast Atg8 PMID: 28287329
    4. O-GlcNAcylation of ATG4B regulates autophagy activation by increasing its proteolytic activity under metabolic stress condition PMID: 27527864
    5. these results demonstrate a novel association of ATG4B positive expression with HER2 positive breast cancers PMID: 27556700
    6. Knockdown of ATG4B had only a minor effect on AMPK activation and G1 phase arrest in liver kinase B1-deficient or AMPK-inhibited cancer cells. PMID: 29169176
    7. Our work describes an MST4-ATG4B signaling axis that influences glioblastoma autophagy and malignancy PMID: 29232556
    8. Data show that ULK1, a protein kinase activated at the autophagosome formation site, phosphorylates human ATG4B on serine 316. PMID: 28821708
    9. Reporter assay showed that HSF1 increased the transcriptional activity of ATG4B gene promoter, and chromatin immunoprecipitation assay verified that HSF1 bound to the site (-1429 to -1417) in ATG4B gene promoter region. PMID: 28889000
    10. The structure and regulatory machinery of Atg4b [review] PMID: 28253956
    11. MIRlet-7i is able to regulate autophagic activity via regulating Atg4B expression, which might contribute to the pathogenesis of pre-eclampsia. PMID: 27770612
    12. Results demonstrated that upregulation of miR-34a by transfection or demethylation resulted in the enhanced apoptosis and drug sensitivity in prostate cancer cells. ATG4B, directly regulated by miR-34a through AMPK/mTOR, was involved in this process. PMID: 26499184
    13. Purified ATG4B protein interact with LC3B in vitro. PMID: 25652856
    14. ATG4B independently plays a role as a positive regulator on tumor proliferation and a negative regulator on autophagy in colorectal cancer cells. PMID: 24991826
    15. This study identifies ATG4B as a potential biomarker for predicting therapeutic response in treatment-naive chronic myeloid leukemia stem/progenitor cells and uncovers ATG4B as a possible drug target in these cells. PMID: 24755409
    16. The actions of ATG4 family members (particularly ATG4B) are required for the control of autophagosome fusion with late, degradative compartments in differentiating human erythroblasts. PMID: 23508006
    17. HsAtg4B negatively regulates the localization of LC3 to a membrane compartment by delipidation PMID: 15187094
    18. analysis of specificity and catalysis of HsAtg4B PMID: 16183633
    19. crystal structure of human Atg4b by X-ray crystallography at 2.0 A resolution, and show that Atg4b is a cysteine protease whose active catalytic triad site consists of Cys74, His280 and Asp278 PMID: 16325851
    20. Murine Atg8L/Apg8L modification is mediated by human Atg4B. PMID: 16704426
    21. The crystal structures of catalytically inert human Atg4B in complex with processed and unprocessed forms of LC3 showed that, on LC3 binding, the regulatory loop and the N-terminal tail of HsAtg4B undergo large conformational changes. PMID: 19322194

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Peptidase C54 family
  • 數據庫鏈接:

    HGNC: 20790

    OMIM: 611338

    KEGG: hsa:23192

    STRING: 9606.ENSP00000384259

    UniGene: Hs.283610



主站蜘蛛池模板: 亚洲性啪啪无码av天堂| 丝袜高潮流白浆潮喷在线播放 | 久久亚洲中文字幕精品一区| 久久婷婷五月综合中文字幕| 国产av天堂亚洲国产av天堂| 欧美老熟妇videos极品另类| 国产xxxx做受性欧美88| 男女做爽爽爽视频免费软件 | 国产精品久人妻精品老妇 | 中文字幕日产乱码国内自| 色妞ww精品视频7777| 久久国产精品精品国产色婷婷| 亚洲中文久久精品无码照片 | 中文字幕亚洲综合久久蜜桃| 女人与拘做受全过程免费视频| 中文字幕人成乱码熟女app| 国产99在线 | 免费| 人妻系列无码一区二区三区| 三上悠亚ssⅰn939无码播放| 欧美日韩免费做爰大片人| 九九热爱视频精品| 亚洲中国精品精华液| 亚洲欧美成人一区二区三区| 综合图片亚洲综合网站| 国产免费无遮挡吸乳视频在线观看| 露脸内射熟女--69xx| 久久zyz资源站无码中文动漫| 精品国产经典三级在线看| 国产片av国语在线观麻豆 | 成人综合伊人五月婷久久| 漂亮人妻熟睡中被公侵犯中文版 | 成人天堂资源www在线| 老司机无码精品a| 激情文学小说区另类小说同性 | 国产av毛片亚洲含羞草社| 国产精品厕所| 精品欧洲av无码一区二区三区| 无码少妇一区二区浪潮免费| 久久天天躁狠狠躁夜夜96流白浆 | 51精品国产人成在线观看| 无码精品久久一区二区三区|