在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ATG3 Antibody

ATG3 Antibody

  • 中文名稱：
    ATG3兔多克隆抗體
  • 貨號：
    CSB-PA914063
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA914063(ATG3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA914063(ATG3 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2610016C12Rik antibody; Apg 3 antibody; APG3 antibody; APG3 autophagy 3 like antibody; APG3 like antibody; APG3, S. cerevisiae, homolog of antibody; APG3-like antibody; APG3L antibody; Apg3p antibody; ATG 3 antibody; ATG3 antibody; ATG3 autophagy related 3 homolog antibody; ATG3 autophagy related 3 homolog (S. cerevisiae) antibody; ATG3_HUMAN antibody; Autophagy 3, S. cerevisiae, homolog of antibody; Autophagy Apg3p/Aut1p like antibody; autophagy related 3 antibody; Autophagy related protein 3 antibody; Autophagy-related protein 3 antibody; DKFZp564M1178 antibody; FLJ22125 antibody; hApg3 antibody; MGC15201 antibody; OTTHUMP00000214547 antibody; OTTHUMP00000214548 antibody; PC3 96 antibody; Protein PC3-96 antibody; Ubiquitin-like-conjugating enzyme ATG3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ATG3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy, and mitochondrial homeostasis. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8-like proteins from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8-like proteins. The formation of the ATG8-phosphatidylethanolamine conjugates is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.
  • 基因功能參考文獻：
    1. ATG3 was targeted by miR-23a, suggesting that ATG3 is an autophagy-related competing endogenous RNA. PMID: 30007957
    2. Results revealed that miR-16 was significantly downregulated, and ATG3 was significantly upregulated in non-small cell lung carcinoma (NSCLC) patient tissue samples. ATG3 was found to be a direct target of miR-16. PMID: 29138833
    3. miR-155 silencing rescued autophagosome number in Mycobacterium tuberculosis infected dendritic cells and enhanced autolysosome fusion, thereby supporting a previously unidentified role of the miR-155 as inhibitor of ATG3 expression. PMID: 29300789
    4. PTK2 inhibition-induced sustained levels of ATG3 were able to sensitize cancer cells to DNA-damaging agents. PMID: 28103122
    5. Our data demonstrate that HOTAIR promotes the activation of autophagy in HCC cells by upregulating the expression of the autophagy-related genes ATG3 and ATG7. PMID: 27301338
    6. ATG3 upregulation contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells PMID: 26061804
    7. Hidden Markov models were used to detect protein homology among the flexible regions of Atg3 homologs and importance of conserved regions evaluated by performing affinity capture experiments with human Atg3 deletion constructs; binding studies and competition experiments demonstrate that overlapping sites in the Atg3FR are important for E3 binding and E1 binding. PMID: 24186333
    8. The region of human ATG3 that interacts with ATG7 is precisely identified using nuclear magnetic resonance. PMID: 26043688
    9. ATG3 gene and its gene family may play an important role in transformation of myelodysplastic syndrome. PMID: 24420857
    10. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. PMID: 24747438
    11. 13 residues of the ATG3 fragment form a short beta-strand followed by an alpha-helix on a surface area that is an exclusive binding site for ATG12. PMID: 24191030
    12. caspase-8 overexpression led to Atg3 degradation and this event depended on caspase-8 enzymatic activity PMID: 22644571
    13. These results unveil a role for ATG12-ATG3 in mitochondrial homeostasis and implicate the ATG12 conjugation system in cellular functions distinct from the early steps of autophagosome formation. PMID: 20723759
    14. Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p PMID: 11825910
    15. Murine Atg8L/Apg8L modification is mediated by human Atg3. PMID: 16704426

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    ATG3 family
  • 組織特異性：
    Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
  • 數據庫鏈接：

    HGNC: 20962

    OMIM: 609606

    KEGG: hsa:64422

    STRING: 9606.ENSP00000283290

    UniGene: Hs.477126



主站蜘蛛池模板： 四虎国产精品永久地址49| 爱久久av一区二区三区| 亚欧日韩欧美网站在线看| 国产精品白浆无码流出视频| 无码无套少妇毛多18pxxxx| 人妻激情另类乱人伦人妻| 99久久久无码国产精品试看| 中文字幕v亚洲日本在线| 精品性影院一区二区三区内射 | 亚洲成a人片在线观看天堂无码| 亚洲国产成人无码网站大全| 国产一区二区三区成人欧美日韩在线观看| 在线观看免费网页欧美成| 国精品人妻无码一区免费视频电影| 欧美 日本 国产 在线a∨观看| 少妇激情一区二区三区视频| 久久精品国产99国产精品澳门| 亚洲精品久久久久久动漫器材一区 | 国产内射一区亚洲| 免费1级a做爰片在线观看| 在线播放免费人成视频在线观看| 大香伊蕉国产av| 97人洗澡从澡人人爽人人模| 亚洲中文字幕a∨在线| 国产三级精品三级| 中文字幕日韩精品一区二区三区| 国产亚洲欧美另类一区二区| 变态另类先锋影音| 亚洲成a人片在线观看日本| 毛片无码一区二区三区a片视频| 人妻洗澡被强公日日澡电影| 亚洲精品成人网线在线播放va | 国产精品99久久久久久www| 欧美人与动交视频在线观看| 欧美性猛交xxxx三人| 精品国产一区二区三区四区| 色综合久久无码五十路人妻| 亚洲国产精品无码久久青草| 久久久女人与动物群交毛片 | 国产精品国产三级国av在线观看| 日产精品久久久一区二区|