在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ATF7 Antibody

ATF7 Antibody

  • 中文名稱：
    ATF7兔多克隆抗體
  • 貨號：
    CSB-PA002279ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ATF7 antibody at 12μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 50, 51, 34, 14, 52 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002279ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA002279ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA002279ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ATF7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ATF7
  • 別名：
    1110012F10Rik antibody; 9430065F09Rik antibody; Activating transcription factor 7 antibody; AI549878 antibody; ATF7 antibody; Atf7 protein antibody; ATF7_HUMAN antibody; ATFA antibody; C130020M04Rik antibody; cAMP-dependent transcription factor ATF-7 antibody; Cyclic AMP-dependent transcription factor ATF 7 antibody; Cyclic AMP-dependent transcription factor ATF-7 antibody; MGC31554 antibody; MGC57182 antibody; Transcription factor ATF A antibody; Transcription factor ATF-A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair.; Acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.; Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
  • 基因功能參考文獻：
    1. ATF7 is a direct target of miR-103a-3p. In a stomach cancer cohort,miR-103a-3p expression was inversely correlated with ATF7 expression. Silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. PMID: 29754469
    2. knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily conserved PMID: 28632756
    3. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. PMID: 26747248
    4. mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression. PMID: 26101806
    5. It is negatively related between ATF7 expression and pathological stage and positive correlation with OS and PFS in CRC. ATF7 expression is a favorable factor for survival of patients with CRC. PMID: 26148593
    6. These results suggest that the Cdk1-mediated phosphorylation of ATF7 facilitates G2/M progression, at least in part, by enabling Aurora signaling. PMID: 25545367
    7. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
    8. Data show that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors. PMID: 21858082
    9. The authors characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase. PMID: 18950637

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus, nucleoplasm. Chromosome, telomere. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.; [Isoform 5]: Cytoplasm.
  • 蛋白家族：
    BZIP family
  • 組織特異性：
    Expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.; [Isoform 4]: Strongly expressed in skeletal muscle. Also expressed at lower levels in heart and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 792

    OMIM: 606371

    KEGG: hsa:11016

    STRING: 9606.ENSP00000329212

    UniGene: Hs.12286



主站蜘蛛池模板： 日韩在线 | 中文| 久久精品无码一区二区日韩av| 很色很爽很黄裸乳视频| 亚洲欧洲无卡二区视頻| 无码国内精品久久人妻蜜桃| 中文字幕制服丝袜第57页| 成人毛片100免费观看| 日本精品人妻无码77777| 国产麻豆放荡av剧情演绎| 亚洲人成伊人成综合网中文| 2020久久超碰国产精品最新| 少妇高潮大叫好爽| 夜夜爽妓女8888视频免费观看| 国产乱子伦三级在线播放| 秋霞国产精品一区二区| 免费网站观看www在线观看| 亚洲综合一区二区三区无码| 成人午夜国产内射主播| 扒开双腿猛进入喷水高潮叫声| 吃奶呻吟打开双腿做受视频| 99re久久精品国产| 精品三级av无码一区| 精品乱码无人区一区二区| 岛国无码av不卡一区二区| 麻豆md0077饥渴少妇| 天天色影网| 又湿又黄裸乳漫画无遮挡网站 | 一本久久综合亚洲鲁鲁五月天| 亚洲精品无码久久久久yw | 玩两个丰满老熟女| 国产影片中文字幕| 亚洲日韩日本中文在线| 亚洲无线卡一卡二| 无罩大乳的熟妇正在播放| 精品久久久久久无码人妻蜜桃 | 亚洲人成小说网站色| 邻居少妇张开腿让我爽了在线观看| 免费无码又爽又刺激高潮视频| 久久无码无码久久综合综合| 99e热久久免费精品首页| 欧美顶级少妇作爱|