在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ATF7 Antibody

ATF7 Antibody

  • 中文名稱：
    ATF7兔多克隆抗體
  • 貨號：
    CSB-PA002279ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: ATF7 antibody at 12μg/ml + Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 53, 50, 51, 34, 14, 52 kDa
      Observed band size: 53 kDa
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA002279ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA002279ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA002279ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ATF7 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ATF7
  • 別名：
    1110012F10Rik antibody; 9430065F09Rik antibody; Activating transcription factor 7 antibody; AI549878 antibody; ATF7 antibody; Atf7 protein antibody; ATF7_HUMAN antibody; ATFA antibody; C130020M04Rik antibody; cAMP-dependent transcription factor ATF-7 antibody; Cyclic AMP-dependent transcription factor ATF 7 antibody; Cyclic AMP-dependent transcription factor ATF-7 antibody; MGC31554 antibody; MGC57182 antibody; Transcription factor ATF A antibody; Transcription factor ATF-A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cyclic AMP-dependent transcription factor ATF-7 protein (1-117AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes such as STAT1 in adipocytes, or genes involved in innate immunity in macrophages and adipocytes. Stress induces ATF7 phosphorylation that disrupts interactions with histone methyltransferase and enhances the association with coactivators containing histone acetyltransferase and/or histone demethylase, leading to disruption of the heterochromatin-like structure and subsequently transcriptional activation. In response to TNF-alpha, which is induced by various stresses, phosphorylated ATF7 and telomerase are released from telomeres leading to telomere shortening. Plays also a role in maintaining epithelial regenerative capacity and protecting against cell death during intestinal epithelial damage and repair.; Acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.; Acts as a negative regulator, inhibiting both ATF2 and ATF7 transcriptional activities. It may exert these effects by sequestrating in the cytoplasm the Thr-53 phosphorylating kinase, preventing activation.
  • 基因功能參考文獻：
    1. ATF7 is a direct target of miR-103a-3p. In a stomach cancer cohort,miR-103a-3p expression was inversely correlated with ATF7 expression. Silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. PMID: 29754469
    2. knockdown of the mammalian homologs of PDK1 and ATF7 in HEK293 cells resulted in changes in metallothionein expression, suggesting that this pathway was evolutionarily conserved PMID: 28632756
    3. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. PMID: 26747248
    4. mitotic stabilized ATF7 protein re-localizes onto chromatin at the end of telophase and contributes to induce the cyclin D1 gene expression. PMID: 26101806
    5. It is negatively related between ATF7 expression and pathological stage and positive correlation with OS and PFS in CRC. ATF7 expression is a favorable factor for survival of patients with CRC. PMID: 26148593
    6. These results suggest that the Cdk1-mediated phosphorylation of ATF7 facilitates G2/M progression, at least in part, by enabling Aurora signaling. PMID: 25545367
    7. ATF7 interacts with TAF12 and contributes to the hypersensitivity of OCL precursors to 1,25-(OH)D in PD. PMID: 23426901
    8. Data show that ATF7-4 is an important cytoplasmic negative regulator of ATF7 and ATF2 transcription factors. PMID: 21858082
    9. The authors characterized the multisite phosphorylation of the ATF7 activation domain and identified one of the involved kinase, p38beta2 mitogen-activated protein kinase. PMID: 18950637

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus, nucleoplasm. Chromosome, telomere. Note=Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.; [Isoform 5]: Cytoplasm.
  • 蛋白家族：
    BZIP family
  • 組織特異性：
    Expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.; [Isoform 4]: Strongly expressed in skeletal muscle. Also expressed at lower levels in heart and lung.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 792

    OMIM: 606371

    KEGG: hsa:11016

    STRING: 9606.ENSP00000329212

    UniGene: Hs.12286



主站蜘蛛池模板： 午夜亚洲国产理论片中文| 牲欲强的熟妇农村老妇女视频| 日韩理论午夜无码| 天天综合网亚在线| 亚洲国产福利一区二区三区| 欧美人妻日韩精品| 中国熟妇牲交视频免费| 一二三四观看视频社区在线 | 精品国产成人高清在线观看| 中文字幕亚洲欧美日韩在线不卡| 日本特黄特色aaa大片免费| 乱色精品无码一区二区国产盗| 国产真实露脸乱子伦原著| 国产福利男女xx00视频| 天堂va欧美ⅴa亚洲va在线| 五月婷婷久久草丁香| 久久青草费线频观看| 免费视频爱爱太爽了激情| 亚洲精品中文字幕久久久久下载 | 欧美日本日韩aⅴ在线视频| 国产老妇伦国产熟女老妇高清| 国产午夜福利短视频| 国产真实乱人偷精品视频| 伦理片午夜视频在线观看| 日本肉体裸xxxxbbbb| 人妻少妇精品久久久久久| 无码人妻久久一区二区三区不卡| 亚洲综合电影小说图片区| 丰满少妇大力进入| 亚洲色成人网站www永久四虎| 无码熟熟妇丰满人妻啪啪 | 亚洲精品tv久久久久久久久j| 99久久99久久精品免费观看| 欧美在线 | 亚洲| 亚洲精品夜夜夜妓女网| 久久亚洲日韩精品一区二区三区| 护士奶头又白又大又好摸视频 | √天堂中文官网8在线| 四房播播开心五月| 国语自产免费精品视频在| 亚洲跨种族黑人xxxxx|