在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATAT1 Antibody, FITC conjugated

  • 中文名稱:
    ATAT1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA725542LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATAT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATAT1
  • 別名:
    Acetyltransferase mec 17 homolog antibody; Acetyltransferase mec-17 homolog antibody; Alpha TAT antibody; Alpha tubulin acetyltransferase 1 antibody; Alpha tubulin N acetyltransferase antibody; Alpha-TAT antibody; Alpha-tubulin N-acetyltransferase antibody; ATAT_HUMAN antibody; ATAT1 antibody; Chromosome 6 open reading frame 134 antibody; Hypothetical protein LOC79969 antibody; MEC17 antibody; Nbla00487 antibody; TAT antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Alpha-tubulin N-acetyltransferase 1 protein (194-238AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
  • 基因功能參考文獻:
    1. these results demonstrate alphaTAT1 enters the lumen of microtubules from open extremities and spreads K40 acetylation marks longitudinally along cellular microtubules; this mode of tip-directed microtubule acetylation may allow for selective acetylation of subsets of microtubules PMID: 27752143
    2. Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage. PMID: 28428427
    3. cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 and initiates ciliogenesis PMID: 25494100
    4. These results suggest that alphaTAT1-mediated Wnt1 expression via microtubule acetylation is important for colon cancer progression. PMID: 27836544
    5. Studies indicate that alpha-tubulin acetylation and microtubule level is mainly governed by opposing actions of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 6 (HDAC6). PMID: 26227334
    6. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia. PMID: 24760594
    7. Data suggest that invariant residues Arg132 and Ser160 in catalytic domain of ATAT1 participate in stable interaction with CoA and acetyl-CoA; ATAT1 with mutation at either residue exhibits much faster intracellular degradation. PMID: 25602620
    8. Crystal structure of the catalytic core of human MEC-17 in complex with acetyl-CoA. MEC17 has large, conserved surface patch that is critical for enzymatic activity suggesting extensive interactions with alpha-tubulin. PMID: 24846647
    9. Mechanistic underpinnings for TAT activity and its preference for microtubules with slow turnover; cocrystal structures constrain TAT action to the microtubule lumen with Lys40 engaged in a suboptimal active site; despite the confined location of Lys40, TAT efficiently scans the microtubule bidirectionally and acetylates stochastically without preference for ends. PMID: 24906155
    10. microtubules contacting clathrin-coated pits become acetylated by alphaTAT1; in migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis PMID: 24097348
    11. cysteine residues play important catalytic roles through a ternary complex mechanism. alphaTAT1 mutations have analogous effects on tubulin acetylation in vitro and in cells PMID: 23071314
    12. analysis reveals a basic patch implicated in substrate binding and a conserved glutamine residue required for catalysis, demonstrating that the family of alpha-tubulin acetyltransferases uses a reaction mechanism different from other lysine acetyltransferases PMID: 23071318

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, axon. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    Acetyltransferase ATAT1 family
  • 數據庫鏈接:

    HGNC: 21186

    OMIM: 615556

    KEGG: hsa:79969

    STRING: 9606.ENSP00000327832

    UniGene: Hs.654798



主站蜘蛛池模板: 蜜桃av蜜臀av色欲av麻| 狠狠色噜噜狠狠狠狠888奇禾 | 免费观看一区二区三区| 色婷婷综合缴情综免费观看| 人妻少妇中文字幕久久| 亚洲欧美日韩成人一区| 天天天天做夜夜夜夜做无码| 中文字幕乱码亚洲无线码三区| 老子影院午夜伦不卡无码 | 欧美性猛交ⅹxxx乱大交妖精| 国产无套内射久久久国产| 性欧美疯狂xxxxbbbb| 国产成人精品a∨一区二区| 日韩不卡1卡2卡三卡2021精品推荐| 国产人妻人伦精品1国产盗摄| 久久精品人妻一区二区蜜桃 | 丰满爆乳一区二区三区| 99热这里只有精品最新地址获取| 国产成人片无码免费视频软件 | 久久久不卡国产精品一区二区 | 最新在线精品国自产拍福利| 国产精品久久久久久久免费看| 国模大胆一区二区三区| 亚洲熟妇无码久久精品| 日本欧美亚洲中文在线观看| 怡红院成永久免费人视频新的| 人人插人人插人人爽| 国产激情久久久久影院老熟女免费| 日韩精品人妻无码久久影院| 秋霞在线观看片无码免费不卡| 国产成人综合色就色综合| 日韩av无码精品人妻系列| 亚洲精品国产av成拍色拍个| 国产精华av午夜在线观看| 亚洲最大av资源站无码av网址| 欧美激情日韩精品久久久| 亚洲最新无码成av人| 精品一卡2卡3卡4卡新区在线| 巨大欧美黑人xxxxbbbb| 99re6在线视频精品免费| 国产精品a国产精品a手机版|