在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATAT1 Antibody, FITC conjugated

  • 中文名稱:
    ATAT1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA725542LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATAT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATAT1
  • 別名:
    Acetyltransferase mec 17 homolog antibody; Acetyltransferase mec-17 homolog antibody; Alpha TAT antibody; Alpha tubulin acetyltransferase 1 antibody; Alpha tubulin N acetyltransferase antibody; Alpha-TAT antibody; Alpha-tubulin N-acetyltransferase antibody; ATAT_HUMAN antibody; ATAT1 antibody; Chromosome 6 open reading frame 134 antibody; Hypothetical protein LOC79969 antibody; MEC17 antibody; Nbla00487 antibody; TAT antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Alpha-tubulin N-acetyltransferase 1 protein (194-238AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.
  • 基因功能參考文獻:
    1. these results demonstrate alphaTAT1 enters the lumen of microtubules from open extremities and spreads K40 acetylation marks longitudinally along cellular microtubules; this mode of tip-directed microtubule acetylation may allow for selective acetylation of subsets of microtubules PMID: 27752143
    2. Depletion of the tubulin acetyltransferase TAT1 led to a significant increase in the frequency of microtubule breakage. PMID: 28428427
    3. cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 and initiates ciliogenesis PMID: 25494100
    4. These results suggest that alphaTAT1-mediated Wnt1 expression via microtubule acetylation is important for colon cancer progression. PMID: 27836544
    5. Studies indicate that alpha-tubulin acetylation and microtubule level is mainly governed by opposing actions of alpha-tubulin acetyltransferase 1 (ATAT1) and histone deacetylase 6 (HDAC6). PMID: 26227334
    6. Results suggest that lithium chloride (LiCl) treatments activate alpha-tubulin N-acetyltransferase 1 (alphaTAT1) by the inhibition of glycogen synthase kinase 3 beta (GSK-3beta) and promote the alpha-tubulin acetylation, and then elongate the primary cilia. PMID: 24760594
    7. Data suggest that invariant residues Arg132 and Ser160 in catalytic domain of ATAT1 participate in stable interaction with CoA and acetyl-CoA; ATAT1 with mutation at either residue exhibits much faster intracellular degradation. PMID: 25602620
    8. Crystal structure of the catalytic core of human MEC-17 in complex with acetyl-CoA. MEC17 has large, conserved surface patch that is critical for enzymatic activity suggesting extensive interactions with alpha-tubulin. PMID: 24846647
    9. Mechanistic underpinnings for TAT activity and its preference for microtubules with slow turnover; cocrystal structures constrain TAT action to the microtubule lumen with Lys40 engaged in a suboptimal active site; despite the confined location of Lys40, TAT efficiently scans the microtubule bidirectionally and acetylates stochastically without preference for ends. PMID: 24906155
    10. microtubules contacting clathrin-coated pits become acetylated by alphaTAT1; in migrating cells, this mechanism ensures the acetylation of microtubules oriented towards the leading edge, thus promoting directional cell locomotion and chemotaxis PMID: 24097348
    11. cysteine residues play important catalytic roles through a ternary complex mechanism. alphaTAT1 mutations have analogous effects on tubulin acetylation in vitro and in cells PMID: 23071314
    12. analysis reveals a basic patch implicated in substrate binding and a conserved glutamine residue required for catalysis, demonstrating that the family of alpha-tubulin acetyltransferases uses a reaction mechanism different from other lysine acetyltransferases PMID: 23071318

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane, clathrin-coated pit. Cell junction, focal adhesion. Cell projection, axon. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle.
  • 蛋白家族:
    Acetyltransferase ATAT1 family
  • 數據庫鏈接:

    HGNC: 21186

    OMIM: 615556

    KEGG: hsa:79969

    STRING: 9606.ENSP00000327832

    UniGene: Hs.654798



主站蜘蛛池模板: 亚洲日韩av无码中文字幕美国| 亚洲欧洲日韩综合久久| 亚洲精品中文字幕无码蜜桃| 久久成人影院精品777| 亚洲中文无码人a∨在线导航| 怀孕挺大肚子疯狂高潮av毛片 | 三级网站视频在在线播放| 久久久久久久人妻无码中文字幕爆 | 日韩中文无码有码免费视频| 久久人人爽av亚洲精品天堂| 国产精品无码专区在线观看| 久久激情综合狠狠爱五月| 色噜噜狠狠色综合av| 国产精品成人av在线观看春天| 亚洲国产一区二区波多野结衣| 日韩午夜理论免费tv影院| 成人无码av一区二区| 中文字幕无线码中文字幕免费| 久久精品中文字幕无码绿巨人| 久久超碰精品一夜七次郎| 无码精品a∨在线观看十八禁| 欧洲精品免费一区二区三区| 麻豆人妻少妇精品无码专区| 国产精品怡红院在线观看| 国产农村黄aaaaa特黄av毛片| 99c视频色欲在线| 国产亚洲精品久久久久蜜臀| 国产99久久九九精品无码| 国产精品真实灌醉女在线播放 | 国产午夜片无码区在线播放| 久久精品国产99国产精品导航 | 久久综合亚洲鲁鲁五月天| 免费网禁国产you女网站下载| 成人三级无码视频在线观看| 欧美男生射精高潮视频网站| 久热这里只精品99国产6-99re视… | 好爽…又高潮了免费毛片| 成人亚洲欧美久久久久| 亚洲中文字幕无码av在线| 国产97色在线 | 免| 久久婷婷五月综合色d啪|