在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ATAD3A Antibody

  • 中文名稱:
    ATAD3A兔多克隆抗體
  • 貨號:
    CSB-PA878897LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      Positive WB detected in: 293T whole cell lysate, A549 whole cell lysate, K562 whole cell lysate
      All lanes: ATAD3A antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 72, 67, 58 kDa
      Observed band size: 72 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ATAD3A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ATAD3A
  • 別名:
    ATAD3A; ATPase family AAA domain-containing protein 3A
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human ATPase family aaA domain-containing protein 3A protein (2-240aa)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ATAD3A Antibody (CSB-PA878897LA01HU),的標記方式是Non-conjugated。對于ATAD3A Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA878897LB01HU ATAD3A Antibody, HRP conjugated ELISA
    FITC CSB-PA878897LC01HU ATAD3A Antibody, FITC conjugated
    Biotin CSB-PA878897LD01HU ATAD3A Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity.
  • 基因功能參考文獻:
    1. ATAD3A region deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism. PMID: 28549128
    2. identification of a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing in five unrelated individuals with a core phenotype of global developmental delay, hypotonia, optic atrophy, axonal neuropathy, and hypertrophic cardiomyopathy PMID: 27640307
    3. Mutations in ATAD3A can thus be dominantly inherited and underlie variable neurological phenotypes, including hereditary spastic paraplegia with intrafamiliar variability. This finding extends the group of mitochondrial inner membrane AAA proteins associated with spasticity. PMID: 28158749
    4. stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles PMID: 25823022
    5. These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria. PMID: 25375035
    6. High ATAD3A expression correlates with radioresistance in glioblastoma. PMID: 24057885
    7. exploring ATAD3 mRNA expression, we confirmed the existence of an alternative splicing in rodent and of several mRNA isoforms in human PMID: 24239551
    8. ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in human pluripotent embryonic stem cells and cancer cells. PMID: 22664726
    9. Engineered a high copy strain expressing human ATAD3A-Myc-HIS at a relative high level (2.5mg/l of yeast culture)without significantly affecting yeast growth.Urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted. PMID: 22542587
    10. ATAD3 may be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular organization and involved in tumorigenesis. PMID: 22318359
    11. Results show that HPV infection correlates with increased ATAD3A expression and drug resistance in uterine cervical cancer. PMID: 21743956
    12. ATAD3 may therefore be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular -organization and involved in tumorigenesis. PMID: 22192748
    13. silencing of ATAD3A expression reduced PSA secretion and cisplatin resistance, suggesting that ATAD3A was associated with PSA secretion and drug resistance in PCa. PMID: 21584487
    14. gene expression in lung adenocarcinoma correlates with drug resistance and poor prognosis PMID: 20332122
    15. The N-terminal part of ATAD3A is outside the inner mitochondrial membrane and that the C-terminal part is inside the matrix. PMID: 20349121
    16. Data show that ATAD3A is a calcium-dependent S100B target protein in oligodendrocyte progenitor cells and suggest that S100B could assist the newly synthesized ATAD3A protein in proper folding and subcellular localization. PMID: 20351179
    17. Data show that the mitochondrial AAA(+) ATPase protein ATAD3A is involved in dynamic interactions between components of the outer and inner mitochondrial membranes which control a number of critical mitochondrial functions. PMID: 20154147
    18. Results suggest that mitochondrial DNA displacement loops serve to recruit ATAD3 protein for the purpose of forming or segregating mitochondrial nucleoids. PMID: 17210950
    19. We also have shown that the loss of ATAD 3A/3B may be involved in the transformation pathway and the chemosensitivity of oligodendrogliomas. PMID: 18639545

    顯示更多

    收起更多

  • 相關疾病:
    Harel-Yoon syndrome (HAYOS)
  • 亞細胞定位:
    Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion matrix, mitochondrion nucleoid.
  • 蛋白家族:
    AAA ATPase family
  • 組織特異性:
    Overexpressed in lung adenocarcinomas (at protein level).
  • 數據庫鏈接:

    HGNC: 25567

    OMIM: 612316

    KEGG: hsa:55210

    STRING: 9606.ENSP00000368030

    UniGene: Hs.23413



主站蜘蛛池模板: 丰满熟妇乱又伦| 亚洲国产成人久久综合一区77| 精品一区二区三人妻视频| 国产丰满麻豆vⅰde0sex| 日日摸处处碰夜夜爽| 欧美牲交a欧美牲交aⅴ久久| 无遮挡又爽又刺激的视频| 人人妻人人爽人人澡av| 久久99精品网久久| 久久精品午夜福利| 国产午夜三级一区二区三| 午夜无码性爽快影院6080| 亚洲一区精品无码色成人| 国产成人综合在线视频| 国产午夜精品一区二区| 久久中文字幕人妻丝袜| 做性久久久久久| 成人免费毛片内射美女-百度| 人妻激情另类乱人伦人妻| 伊人色综合久久天天小片| 日本一道一区二区视频| 无码高潮喷水在线观看| 精品国产欧美一区二区| 丝袜高跟麻麻浓精受孕人妻| 成 人 网 站不卡在线观看| 国产成人无码一二三区视频| 国产网红主播无码精品| 欧美成人精品一区二区综合a片| 日韩无套内射高潮| 国产东北肥熟老胖女| 亚洲午夜精品一区二区| 中国少妇初尝黑人巨高清 | 精品国产一区二区三区四区阿崩| 欧美 国产 日产 韩国 在线 | 亚洲国产成人精品无码区软件| 一本无码中文字幕在线观| 国产欧美精品一区二区三区| 亚洲毛片不卡av在线播放一区| 亚洲欧美成人综合图区| 国产又a又黄又潮娇喘视频| 色狠狠久久av五月综合|