在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ASPSCR1 Antibody

ASPSCR1 Antibody

  • 中文名稱：
    ASPSCR1兔多克隆抗體
  • 貨號：
    CSB-PA866328ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA866328ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA866328ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ASPSCR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ASPSCR1
  • 別名：
    Alveolar soft part sarcoma chromosomal region candidate gene 1 protein antibody; Alveolar soft part sarcoma chromosome region candidate 1 (human) antibody; Alveolar soft part sarcoma locus antibody; ASPC antibody; ASPC1_HUMAN antibody; ASPCR 1 antibody; ASPCR1 antibody; ASPL antibody; ASPS antibody; ASPSCR 1 antibody; Aspscr1 antibody; FLJ45380 antibody; RCC 17 antibody; RCC17 antibody; renal cell carcinoma gene on chromosome 17 antibody; renal cell carcinoma papillary 17 antibody; Renal papillary cell carcinoma protein 17 antibody; Tether containing a UBX domain for GLUT4 antibody; Tether containing UBX domain for GLUT4 antibody; TUG antibody; UBX domain containing protein 9 antibody; UBX domain protein 9 antibody; UBX domain-containing protein 9 antibody; UBXD 9 antibody; UBXD9 antibody; UBXN 9 antibody; UBXN9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tether containing UBX domain for GLUT4 protein (284-553AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT.
  • 基因功能參考文獻：
    1. ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL. Overproduction of ASPL disrupts p97 hexamer function in endoplasmic reticulum-associated protein degradation. PMID: 27762274
    2. These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression. PMID: 27673450
    3. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25. PMID: 26516944
    4. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile. PMID: 25453902
    5. ASPL is a cofactor of the hexameric ATPase complex, known as p97. The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 N-domain. PMID: 25078495
    6. Results support a gain-of-function role for ASPSCR1-TFE3 contributing to proliferation and survival of cancer cells. PMID: 23288701
    7. Promotes methylation of VCP by METTL21D PMID: 23349634
    8. Data support a model in which TUG controls p97 oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types. PMID: 22207755
    9. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique. PMID: 21835426
    10. Immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma. PMID: 21279521
    11. Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma PMID: 18176180

    顯示更多

    收起更多

  • 相關疾病：
    A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.
  • 亞細胞定位：
    Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
  • 組織特異性：
    Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.
  • 數據庫鏈接：

    HGNC: 13825

    OMIM: 606236

    KEGG: hsa:79058

    STRING: 9606.ENSP00000302176

    UniGene: Hs.298351



主站蜘蛛池模板： 军人粗大的内捧猛烈进出视频 | 无码人妻一区二区三区线| 激情五月综合色婷婷一区二区| 国产精品自在在线午夜出白浆| 国产成人无码a区在线观看导航| 日韩 无码 偷拍 中文字幕| 国产一区丝袜在线播放| 国产一区丝袜在线播放| 欧美日韩国产专区一区二区| 免费观看成人欧美www色| 国产人妖视频一区二区| 美女裸体跪姿扒开屁股无内裤| 亚洲国产成人精品一区刚刚| 清纯唯美经典一区二区| 久久不见久久见免费影院国语| 丰满少妇熟乱xxxxx视频| 99久久婷婷国产综合精品电影| 国产精品亚洲精品日韩已满| 久久青青草原国产精品最新片 | 无码色偷偷亚洲国内自拍| 久热在线这里只有精品国产| 少妇高潮惨叫久久久久电影| 日日噜狠狠噜天天噜av| 人妻中文字幕无码专区| 国产精品亚洲一区二区三区| 亚洲欧美综合成人五月天网站| 丰满少妇被猛烈进入试看| 久久99精品国产麻豆宅宅| 无遮挡又爽又刺激的视频 | 国产色无码精品视频免费| 最新精品香蕉在线| 免费无码a片一区二三区| 国产一卡2卡3卡4卡精品| 人人超碰人人爱超碰国产| 欧美大浪妇猛交饥渴大叫| 精品成人免费国产片| 九九久久精品国产波多野结衣| 真人无码作爱免费视频| 日韩综合夜夜香内射| 午夜福利一区二区三区高清视频 | 亚洲中文无码a∨在线观看|