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  4. ASPSCR1 Antibody

ASPSCR1 Antibody

  • 中文名稱：
    ASPSCR1兔多克隆抗體
  • 貨號：
    CSB-PA866328ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA866328ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA866328ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ASPSCR1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ASPSCR1
  • 別名：
    Alveolar soft part sarcoma chromosomal region candidate gene 1 protein antibody; Alveolar soft part sarcoma chromosome region candidate 1 (human) antibody; Alveolar soft part sarcoma locus antibody; ASPC antibody; ASPC1_HUMAN antibody; ASPCR 1 antibody; ASPCR1 antibody; ASPL antibody; ASPS antibody; ASPSCR 1 antibody; Aspscr1 antibody; FLJ45380 antibody; RCC 17 antibody; RCC17 antibody; renal cell carcinoma gene on chromosome 17 antibody; renal cell carcinoma papillary 17 antibody; Renal papillary cell carcinoma protein 17 antibody; Tether containing a UBX domain for GLUT4 antibody; Tether containing UBX domain for GLUT4 antibody; TUG antibody; UBX domain containing protein 9 antibody; UBX domain protein 9 antibody; UBX domain-containing protein 9 antibody; UBXD 9 antibody; UBXD9 antibody; UBXN 9 antibody; UBXN9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Tether containing UBX domain for GLUT4 protein (284-553AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Enhances VCP methylation catalyzed by VCPKMT.
  • 基因功能參考文獻：
    1. ASPL efficiently promotes p97 hexamer disassembly, resulting in the formation of stable p97:ASPL. Overproduction of ASPL disrupts p97 hexamer function in endoplasmic reticulum-associated protein degradation. PMID: 27762274
    2. These results show that ASPL-TFE3 regulates cell cycle progression and induces cellular senescence by up-regulating p21 expression. PMID: 27673450
    3. Studies indicate that alveolar soft part sarcoma showed a specific chromosomal alteration, der(17)t(X:17)(p11:q25), resulting in the fusion of the TFE3 transcription factor gene (Xp11) with alveolar soft part sarcoma critical region 1 (ASPSCR1) at 17q25. PMID: 26516944
    4. A conditional expression in mice of the fusion gene ASPSCR1-TFE3 from human alveolar soft part sarcoma (ASPS) generated a model that recapitulates the human tumor histologically and by expression profile. PMID: 25453902
    5. ASPL is a cofactor of the hexameric ATPase complex, known as p97. The central area in ASPL, containing both a SHP box and a UBX domain, is required for binding to the p97 N-domain. PMID: 25078495
    6. Results support a gain-of-function role for ASPSCR1-TFE3 contributing to proliferation and survival of cancer cells. PMID: 23288701
    7. Promotes methylation of VCP by METTL21D PMID: 23349634
    8. Data support a model in which TUG controls p97 oligomeric status at a particular location in the early secretory pathway and in which this process regulates membrane trafficking in various cell types. PMID: 22207755
    9. In alveolar soft part sarcomas with unusual locations or histology, we consider that the detection of the ASPSCR1-TFE3 fusion transcript would be the highly effective diagnostic technique. PMID: 21835426
    10. Immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts are powerful tools in the diagnosis of alveolar soft part sarcoma. PMID: 21279521
    11. Immunohistochemical discrimination between the ASPL-TFE3 fusion proteins of alveolar soft part sarcoma PMID: 18176180

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  • 相關疾病：
    A chromosomal aberration involving ASPSCR1 is found in patients with alveolar soft part sarcoma. Translocation t(X;17)(p11;q25) with TFE3 forms a ASPSCR1-TFE3 fusion protein.
  • 亞細胞定位：
    Endomembrane system; Peripheral membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Peripheral membrane protein. Cytoplasm. Nucleus.
  • 組織特異性：
    Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas.
  • 數據庫鏈接：

    HGNC: 13825

    OMIM: 606236

    KEGG: hsa:79058

    STRING: 9606.ENSP00000302176

    UniGene: Hs.298351



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