在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ASB2 Antibody

ASB2 Antibody

  • 中文名稱：
    ASB2兔多克隆抗體
  • 貨號：
    CSB-PA064362
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA064362(ASB2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA064362(ASB2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ASB2
  • 別名：
    ASB2Ankyrin repeat and SOCS box protein 2 antibody; ASB-2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human ASB2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2. Required during embryonic heart development for complete heart looping. Required for cardiomyocyte differentiation.; Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA. Also targets DES for proteasomal degradation. Acts as a negative regulator of skeletal muscle mass.; Targets filamins FLNA and FLNB for proteasomal degradation. This leads to enhanced adhesion of hematopoietic cells to fibronectin. Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes. Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix. Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells.
  • 基因功能參考文獻(xiàn)：
    1. Notch signaling can initiate Asb2 transcription and NF-kappa B activation in T cell acute lymphoblastic leukemia cells. PMID: 30116272
    2. Using ASB2 conditional knockout mice. PMID: 26537633
    3. Phosphorylation of serine 323 of ASB2 alpha by Erk kinases is critical for ASB2alpha-mediated degradation of FLNA. PMID: 24044920
    4. data therefore reveal ubiquitin acceptor sites in FLNa and establish that ASB2alpha-mediated effects on cell spreading are due to loss of filamins. PMID: 24052262
    5. Data show that neither endogenous nor exogenously expressed ASB2alpha induces degradation of JAK proteins in hematopoietic cells PMID: 22916308
    6. These results suggest that ASB2beta but not ASB2alpha might be monoubiquitinated and that the ASB2beta UIM motif, but not its E3 Ub ligase activity, plays a pivotal role in this monoubiquitination. PMID: 22382022
    7. A model whereby ASB2 contributes to hematopoietic differentiation, in part, through MLL degradation and HOX gene down-regulation. PMID: 22174154
    8. ASB2alpha is a novel regulator of integrin-dependent adhesion of hematopoietic cells PMID: 21737450
    9. By shifting monomeric E3 ligase complexes to dimeric forms through activation of Asb2 transcription, Notch could effectively control the turnover of a variety of substrates and it exerts diverse effects on cell proliferation and differentiation. PMID: 21119685
    10. ASB2 may regulate hematopoietic cell differentiation by modulating cell spreading and actin remodeling through targeting of filamins A and B for degradation. PMID: 18799729

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, stress fiber.; [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Ankyrin SOCS box (ASB) family
  • 組織特異性：
    [Isoform 1]: Expressed in muscle cells.; [Isoform 2]: Expressed in hematopoietic cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16012

    OMIM: 605759

    KEGG: hsa:51676

    STRING: 9606.ENSP00000451575

    UniGene: Hs.510327



主站蜘蛛池模板： www国产亚洲精品久久麻豆| 性色av无码不卡中文字幕| 香蕉影院在线观看| 韩国三级hd中文字幕| 欧美婷婷丁香五月社区| 国产精品无码av不卡顿| 人人妻人人玩人人澡人人爽| 性欧美丰满熟妇xxxx性久久久| 国产精品高清一区二区不卡片| 亚洲va中文字幕无码一二三区| 国产丝袜一区视频在线观看| 国产av麻豆mag剧集| 国产成人av国语在线观看| 中文字幕精品亚洲人成在线| 黑人巨大精品欧美一区二区| 99久久国语露脸精品国产| 亚洲欧洲自拍拍偷综合| 国产精品久久毛片| 国产极品美女高潮无套在线观看| 风韵人妻丰满熟妇老熟女| 久久九九精品国产免费看小说| 天天摸天天做天天爽水多| 天堂一区人妻无码| 国产欧美日韩另类在线专区| 日本xxx在线观看免费播放| 无码人妻av一区二区三区蜜臀 | 6699嫩草久久久精品影院| 好爽…又高潮了免费毛片| 无码ol丝袜高跟秘书在线观看| 日韩中文无码有码免费视频| 色噜噜狠狠色综合久夜色撩人| 欧美va免费高清在线观看| 国产女人叫床高潮大片| 亚洲欧美国产精品专区久久| 亚洲一卡一卡二新区无人区| 亚洲 制服丝袜 中文字幕 在线| 午夜日本大胆裸艺术| 久久久中文久久久无码| 国产 av 仑乱内谢| 国产精品日本一区二区不卡视频| 无码高潮少妇毛多水多水免费|