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ARV1 Antibody

  • 中文名稱：
    ARV1兔多克隆抗體
  • 貨號：
    CSB-PA867134EA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescent analysis of A2780 cells using CSB-PA867134EA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ARV1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ARV1
  • 別名：
    ARV1; HT035; Protein ARV1; hARV1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein ARV1 protein (1-143AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ARV1 Antibody (CSB-PA867134EA01HU)，的標記方式是Non-conjugated。對于ARV1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA867134EB01HU ARV1 Antibody, HRP conjugated ELISA
    FITC CSB-PA867134EC01HU ARV1 Antibody, FITC conjugated
    Biotin CSB-PA867134ED01HU ARV1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes.
  • 基因功能參考文獻：
    1. In contrast to wild type human ARV1, neither variant expressed detectable levels of protein in mammalian cells. Mice with a neuronal deletion of Arv1 recapitulated the human phenotype, exhibiting seizures and a severe survival defect in adulthood. Our data support ARV1 deficiency as a cause of autosomal recessive epileptic encephalopathy PMID: 27270415
    2. A novel function for Arv1 in regulation of cell division through promotion of the contractile actomyosin ring, which is independent of its lipid transporter activity. PMID: 27104745
    3. Overexpression of human ARV1 could rescue the phenotypes associated with GPI anchor synthesis defect in the yeast arv1Delta mutant. Arv1 function in GPI biosynthesis may be conserved in all eukaryotes, from yeast to humans. PMID: 26460143
    4. These results implicate ARV1 as a protective factor in lipotoxic diseases due to modulation of fatty acid metabolism. PMID: 24273168
    5. Arv1p has a role in sterol movement from the ER and in the ensuing regulation of hepatic cholesterol and bile acid metabolism PMID: 20663892
    6. ARV1 plays a role in sphingolipid metabolism and complements yeast ARV1 PMID: 12145310

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  • 相關疾病：
    Epileptic encephalopathy, early infantile, 38 (EIEE38)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    ARV1 family
  • 組織特異性：
    Ubiquitous. Highly expressed in liver and adipose.
  • 數據庫鏈接：

    HGNC: 29561

    OMIM: 611647

    KEGG: hsa:64801

    STRING: 9606.ENSP00000312458

    UniGene: Hs.275736



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