在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARL8B Antibody

  • 中文名稱:
    ARL8B兔多克隆抗體
  • 貨號:
    CSB-PA002100GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ARL8B
  • 別名:
    ADP ribosylation factor like 10C antibody; ADP ribosylation factor like 8B antibody; ADP-ribosylation factor-like protein 10C antibody; ADP-ribosylation factor-like protein 8B antibody; ARL10C antibody; ARL8B antibody; ARL8B_HUMAN antibody; FLJ10702 antibody; Gie1 antibody; Novel small G protein indispensable for equal chromosome segregation 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ARL8B
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells. In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function. Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense. Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes. Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes. May play a role in chromosome segregation.; (Microbial infection) During Mycobacterium tuberculosis (Mtb) infection, is required for plasma membrane repair by controlling the exocytosis of lysosomes in macrophages. ARL8B secretion pathway is crucial to control the type of cell death of the M. tuberculosis-infected macrophages, distinguishing avirulent from virulent Mtb induced necrotic cell death.; (Microbial infection) During infection, coronaviruses such as SARS-CoV-2 and the chaperone HSPA5/GRP78 are probably co-released through ARL8B-dependent lysosomal exocytic pathway for unconventional egress.
  • 基因功能參考文獻:
    1. Authors present evidence that Arl8b facilitates lipid hydrolysis to maintain efficient metabolism for a proliferative capacity in low nutrient environments, suggesting a likely explanation for the complete inability of Arl8b-depleted tumor cells to grow in vivo. PMID: 27105540
    2. Data indicate that E3 ubiquitin-protein ligase RNF167 ubiquitinates Arl8B at the lysine residue K141 and reduces the level of the ADP-ribosylation factor-like 8B Arl8B protein. PMID: 27808481
    3. Arl8b regulates the association of the human HOPS complex with lysosomal membranes. PMID: 25908847
    4. a small GTP-binding protein, ADP-ribosylation factor-like 8b (Arl8b), is identified as a critical factor required for NK cell-mediated cytotoxicity. PMID: 24088571
    5. The authors find that Arl8B is required for kinesin-1 recruitment to Salmonella-containing vacuoles, migration of the vacuoles to the cell periphery 24 h after infection and for cell-to-cell transfer of bacteria to neighbouring cells. PMID: 21824248
    6. a critical regulator of cargo delivery to lysosomes PMID: 21802320
    7. Results suggest that the novel GTPases Gie1 and Gie2 associate with microtubules, and might be involved in chromosome segregation. PMID: 15331635
    8. Arl8b is involved in trafficking processes for lysosomes. PMID: 16650381
    9. Data show that with MAK3 knockdown, p53 is stabilized and phosphorylated and there is a significant transcriptional activation of proapoptotic genes downstream of p53, and that localization of Arl8b is altered, suggesting that Arl8b is a Mak3 substrate. PMID: 19398576

    顯示更多

    收起更多

  • 亞細胞定位:
    Late endosome membrane. Lysosome membrane. Cytoplasm, cytoskeleton, spindle. Cell projection, axon. Cell junction, synapse. Cytolytic granule membrane.
  • 蛋白家族:
    Small GTPase superfamily, Arf family
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 25564

    OMIM: 616596

    KEGG: hsa:55207

    STRING: 9606.ENSP00000256496

    UniGene: Hs.250009



主站蜘蛛池模板: 欧美成人无码a区视频在线观看| 免费人成网站视频在线观看| 亚洲国产精品无码中文字满| 综合无码成人aⅴ视频在线观看 | 800av凹凸视频在线观看| 亚洲码欧美码一区二区三区| 国产免费又爽又色又粗视频| 国精品无码一区二区三区在线蜜臀 | 国产综合在线观看| 男女做爰真人视频直播| 欧美成人家庭影院| 成在人线av无码免费高潮水老板| 日本道免费精品一区二区| 国产亚洲曝欧美曝妖精品| 国产女人水真多18毛片18精品| 中文人妻熟女乱又乱精品| 久久99国产综合精品免费| 中文字幕第一区高清av| 国产成人免费无庶挡视频| 久久99热只有频精品8| 亚洲熟妇丰满多毛xxxx| 色噜噜狠狠色综合久夜色撩人| 男人撕开奶罩揉吮奶头视频| 成人一区二区免费中文字幕视频| 小12箩利洗澡无码视频网站| 狠狠躁18三区二区一区ai明星| 一个人看的日本hd免费| 欧美成人免费全部| 爆乳护士一区二区三区在线播放| 日本japanese漂亮丰满| 久久久久久成人毛片免费看| 国产精品成人免费一区久久羞羞| 国产精品视频一区二区亚瑟| 亚洲精品久久久久午夜福利| 欧美变态另类刺激| 在线亚洲欧美日韩精品专区| 亚洲精品国偷自产在线99人热| 青青青国产精品一区二区| 国产私人尤物无码不卡| 亚洲精品日韩一区二区小说| 国产三级在线观看播放视频|