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ARL6IP5 Antibody

  • 中文名稱:
    ARL6IP5兔多克隆抗體
  • 貨號:
    CSB-PA002096LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA002096LA01HU at dilution of 1:100
    • Immunofluorescent analysis of Hela cells using CSB-PA002096LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ARL6IP5 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ARL6IP5
  • 別名:
    ARL6IP5; DERP11; JWA; PRA2; PRAF3; HSPC127; PRA1 family protein 3; ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5; Cytoskeleton-related vitamin A-responsive protein; Dermal papilla-derived protein 11; GTRAP3-18; Glutamate transporter EAAC1-interacting protein; JM5; Prenylated Rab acceptor protein 2; Protein JWa; Putative MAPK-activating protein PM27
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PRA1 family protein 3 protein (136-188AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ARL6IP5 Antibody (CSB-PA002096LA01HU),的標記方式是Non-conjugated。對于ARL6IP5 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA002096LB01HU ARL6IP5 Antibody, HRP conjugated ELISA
    FITC CSB-PA002096LC01HU ARL6IP5 Antibody, FITC conjugated
    Biotin CSB-PA002096LD01HU ARL6IP5 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. Plays a role in the retention of SLC1A1/EAAC1 in the endoplasmic reticulum.
  • 基因功能參考文獻:
    1. These data demonstrated that JWA suppressed the migration/invasion of breast carcinoma cells by downregulating the expression of CXCR4, and suggested that JWA may harbor prognostic and therapeutic potential in patients with breast cancer. PMID: 29658570
    2. increased RNF185 expression facilitated GC cell migration in vitro and promoted GC metastasis in vivo by downregulating JWA expression. PMID: 29481911
    3. our results demonstrate that JWA is a novel negative regulator of HER2 expression...in HER2-positive gastric cancer cells PMID: 27167206
    4. Protective effect of JWA against paraquat neurotoxicity involves regulation of the MEK/PI3K-Nrf2 axis. PMID: 28428137
    5. JWA and topoisomerase II alpha regulate each other in tumor cells arrested in G2/M. PMID: 26046674
    6. the JWA gene may regulate human breast cancer cells through the MAPK signaling pathway using different types of regulation. PMID: 25586271
    7. This review gives an overview of EAAC1-mediated GSH synthesis, and its regulatory mechanisms by GTRAP3-18 in the brain, and a potential approach against neurodegeneration. PMID: 23109897
    8. JWA reverses cisplatin resistance via the CK2-XRCC1 pathway in human gastric cancer cells. PMID: 25476899
    9. data demonstrate that JWA plays a crucial role in HCC progression and suggest JWA may be a potential prognostic biomarker and therapeutic target for HCC. PMID: 23169062
    10. A significant negative correlation between JWA and ILK in melanoma biopsies. PMID: 24064223
    11. Loss of JWA expression was strongly correlated with increased gastric cancer angiogenesis. PMID: 24072772
    12. JWA has an important role in ING4-regulated melanoma angiogenesis, and ING4/JWA/ILK are promising prognostic markers and may be used as anti-angiogenic therapeutic targets for melanoma. PMID: 24157826
    13. A combined effect of p53 with JWA as efficient prognostic indicators was found for the first time. PMID: 23285001
    14. JWA plays an important role in the occurrence and progress of human esophageal squamous cell carcinoma (ESCC) and that high expression level of JWA may predict a favorable prognosis in ESCC patients. PMID: 23461062
    15. JWA and XRCC1 protein levels were downregulated in gastric cancer lesions compared with adjacent noncancerous tissues;JWA and XRCC1 protein expressions in tumor are candidate prognostic markers and predictive factors for benefit from adjuvant platinum-based chemotherapy in resectable gastric carcinoma PMID: 22452940
    16. The gene polymorphisms at site 76 and GG/CT haploid type of JWA gene were associated with hypertension in workers exposed to high temperature. PMID: 22357531
    17. PRAF3 plays an important role in the regulation of tumor progression and metastasis and serves as a tumor suppressor in human ESCC. We propose that PRAF3 might be used as a potential therapeutic agent for human ESCC. PMID: 22433565
    18. JWA night play an important role in neoplastic transformation of HBE cells through regulation of p53 expression. PMID: 19080375
    19. all-trans retinoic acid increased JWA gene expression in human pulmonary artery smooth muscle cells. PMID: 16638297
    20. Rsults suggest that JWA can be regulated by oxidative stress and is actively involved in the signal pathways of oxidative stress in the cells. PMID: 15864752
    21. Data show that the JWA -76G-->C variant genotype may play an important role in transcription regulation of JWA gene and in the susceptibility to bladder cancer. PMID: 16331563
    22. JWA may function as a lineage-restricted gene during differentiation along the monocyte/macrophage-like or granulocytic pathway PMID: 16430862
    23. all-trans retinoic acid up-regulates JWA expression by stimulating the transcriptional activity of JWA gene promoter PMID: 16468075
    24. The JWA determined might function as a potential effective environmental responsive gene and actively participated in the process of B (a) P exposure associated with intracellular signal pathways of DNA damage and repair PMID: 16640902
    25. JWA participates in the signal pathways of H2O2 induced oxidative stress in K562 cells PMID: 16766476
    26. The effects of All Trans Retinoic Acid in regulating cellular proliferation and apoptosis may be mediated in part by JWA expression. PMID: 16922813
    27. JWA regulated-tumor cellular migration might involve MAPK cascades activation and F-actin cytoskeleton rearrangement mechanisms. PMID: 17336041
    28. Three novel functional genetic poly- morphisms of JWA gene, -76C, 454A, and 723G, appear to contribute to the etiology of bladder cancer PMID: 17479401
    29. Single nucleotide polymorphisms of JWA were associated with enhanced risk of gastric cancer and esophageal squamous cell carcinoma in a Chinese population. PMID: 17479402
    30. The potentially functional genetic polymorphism 454CA of the JWA gene appears to contribute to the risk of multiple kinds of leukemia in a south Chinese population. PMID: 17479403
    31. These results show GTRAP3-18 to negatively and dominantly regulate cellular GSH content via interaction with EAAC1 at the plasma membrane. PMID: 17646425
    32. Expression of GTRAP3-18 delays the ER exit of EAAC1, as well as other members of the excitatory amino acid transporter family. PMID: 18167356
    33. This paper deals primarily with PRAF2, but comparisons with PRAF3 are also provided. PMID: 16481131
    34. protein expression is upregulated by methyl-beta-cyclodextrin and not by retinoic acid PMID: 12562531
    35. highly conserved protein and genomic organization amongst vertebrates PMID: 12119102

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  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    PRA1 family
  • 數據庫鏈接:

    HGNC: 16937

    OMIM: 605709

    KEGG: hsa:10550

    STRING: 9606.ENSP00000273258

    UniGene: Hs.518060



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