在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARL2 Antibody

ARL2 Antibody

  • 中文名稱：
    ARL2兔多克隆抗體
  • 貨號：
    CSB-PA079391
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 12%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA079391(ARL2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ARL2
  • 別名：
    ADP ribosylation factor like 2 antibody; ADP-ribosylation factor-like protein 2 antibody; ARFL2 antibody; Arl184 antibody; Arl2 antibody; ARL2_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human ARL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Also regulates mitochondrial integrity and function.
  • 基因功能參考文獻：
    1. High ARL2 expression is associated with Osteosarcoma. PMID: 29265919
    2. conclude that the TBCD*ARL2*beta-tubulin complex represents a functional intermediate in the beta-tubulin folding pathway whose activity is regulated by the cycling of nucleotides on ARL2 PMID: 28970104
    3. Results identified ARL2 and TBCD, as important in tubulin folding and microtubule dynamics. Both ARL2 and TBCD also localize to centrosomes. A growing body of evidence also has found roles for ARL2 inside mitochondria, as a regulator of mitochondrial fusion, and in the traffic of farnesylated cargos between membranes and specifically to cilia and photoreceptor cells. [review] PMID: 27400436
    4. In conclusion, our study revealed that miR-214 acts as a tumor suppressor via inhibiting proliferation, migration and invasion of cervical cancer cells through targeting ARL2, and that both miR-214 and ARL2 may serve as prognostic or therapeutic targets for cervical cancer. PMID: 28137590
    5. Novel Biochemical and Structural Insights into the Interaction of Myristoylated Cargo with Unc119 Protein and Their Release by Arl2/3. PMID: 27481943
    6. We hypothesize that ARL2 plays essential roles inside mitochondria along with other cellular functions, at least in part to provide coupling of regulation between these essential cell processes. PMID: 24911211
    7. MiR-195 regulates cell apoptosis in a context-dependent manner through directly targeting ARL2. PMID: 23807224
    8. The G proteins Arl2 acts in a GTP-dependent manner as allosteric release factors for farnesylated cargo. PMID: 22002721
    9. a novel function of miR-16 targeting ARL2 in modulating proliferation and cell cycle progression. PMID: 21199864
    10. Data show that bovine and human TBCD have functionally identical roles in tubulin heterodimer assembly, and that the inability of human TBCD to disrupt microtubule integrity can be overcome by siRNA-mediated suppression of expression of Arl2. PMID: 20740604
    11. C. elegans evl-20 gene encodes a functional homolog of human ARL2. Elimination of evl-20 function results in abnormal vulval, gonad, and male tail development and disrupts embryonic proliferation, hypodermal enclosure, and elongation. PMID: 12015966
    12. Arl2 is present in centrosomes and propose that its action in regulating tubulin polymerization is mediated at centrosomes PMID: 16525022
    13. In summary, alterations in Arl2 protein content were found to be associated with modifications in tubulin pools, microtubule dynamics as well as cell cycle progression. PMID: 17188265
    14. ARL2 and beta-tubulin cofactor D participate in AJC disassembly and epithelial depolarization PMID: 17704193
    15. Arl2 and Arl3 interactions were characterized. PMID: 18588884
    16. Arl2 could, via protein phosphatase 2A , influence p53 phosphorylation status. PMID: 18818514
    17. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. PMID: 19368893

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm.
  • 蛋白家族：
    Small GTPase superfamily, Arf family
  • 數據庫鏈接：

    HGNC: 693

    OMIM: 601175

    KEGG: hsa:402

    STRING: 9606.ENSP00000246747

    UniGene: Hs.502836



主站蜘蛛池模板： 极品少妇高潮到爽| 97色成人综合网站| 99热久久精里都是精品6| 久久综合伊人| .精品久久久麻豆国产精品| 在线视频免费观看爽爽爽| 欧美 日韩 亚洲 在线| 免费国产高清毛不卡片基地| 亚洲热妇无码av在线播放| 日本免费一区二区三区| 天天躁日日躁狠狠躁欧美老妇小说| 欧美性猛交xxxx黑人| 日日摸天天摸人人看| 少妇的丰满人妻hd高清| 四虎成人精品在永久免费| 色噜噜狠狠一区二区三区果冻| 呻吟国产av久久一区二区| 久久理论片午夜琪琪电影网| 亚洲熟妇无码另类久久久| 女人张开腿让男桶喷水高潮| 国产精品人妻系列21p| 情侣激情18内射骚话国产| 亚 洲 视 频 高 清 无 码| 香港三级日本三级a视频| 最新精品露脸国产在线| 米奇7777狠狠狠狠视频影院| 人妻大战黑人白浆狂泄| 强被迫伦姧惨叫人妻系列| 久久精品国产久精国产爱| 午夜精品一区二区三区在线观看 | 国产成人免费ā片在线观看| 国产99久久亚洲综合精品西瓜tv| 饥渴少妇高潮视频大全| 午夜福利电影| 全部av―极品视觉盛宴| 麻婆豆传媒一区二区三区| 中文字幕av免费专区| 亚洲精品成人片在线观看精品字幕 | 99精品国产兔费观看久久| 国产清纯美女遭强到高潮| 国产精品无码v在线观看|