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ARHGEF9 Antibody

  • 中文名稱:
    ARHGEF9兔多克隆抗體
  • 貨號(hào):
    CSB-PA008344
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    ARHGEF9
  • 別名:
    9630036L12Rik antibody; A230067K14 antibody; ARHG9_HUMAN antibody; Arhgef9 antibody; Cdc42 guanine nucleotide exchange factor (GEF) 9 antibody; Collybistin antibody; collybistin I antibody; EIEE8 antibody; HPEM 2 antibody; hPEM-2 collybistin antibody; KIAA0424 antibody; mKIAA0424 antibody; OTTHUMP00000023424 antibody; OTTHUMP00000023425 antibody; OTTHUMP00000023427 antibody; PEM 2 antibody; PEM 2 homolog antibody; PEM-2 homolog antibody; PEM2 antibody; Rac/Cdc42 guanine nucleotide exchange factor 9 antibody; Rho guanine nucleotide exchange factor 9 antibody; RP11 357C3.4 antibody; RP23 230K20.3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human ARHGEF9.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
  • 基因功能參考文獻(xiàn):
    1. Autism spectrum disorder patient with the smallest inactivating deletion in the collybistin gene. PMID: 27238888
    2. Collybistin forms a complex with mTOR and eIF3 and by sequestering these proteins downregulates mTORC1 signaling and protein synthesis potentially contributing to intellectual disability and autism. PMID: 25898924
    3. Impairment of the membrane lipid binding activity of Collybistin R290H and a consequent defect in inhibitory synapse maturation represent a likely molecular pathomechanism of epilepsy and mental retardation in humans. PMID: 25678704
    4. Data indicate that ARHGEF9 is likely to be responsible for syndromic X-linked mental retardation associated with epilepsy. PMID: 21633362
    5. These results reveal that G(s) and G(q) signalings regulate hPEM-2 functions through PKA and c-Src in Neuro-2a neuroblastoma cells, respectively. PMID: 22033413
    6. major regulator of GABAergic postsynaptic gephyrin clustering PMID: 21807943
    7. Here we identified residues critical for interaction with gephyrin in the linker region between the SH3 and the DH domains of collybistin. PMID: 11727829
    8. translocates gephyrin to submembrane microaggregates; collybistin mutation (G55A)is found in exon 2 of the ARHGEF9 gene in a patient with clinical symptoms of both hyperekplexia and epilepsy PMID: 15215304
    9. Results show that hPEM-2 is a target protein of Smurf1. PMID: 18208356

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  • 相關(guān)疾病:
    Epileptic encephalopathy, early infantile, 8 (EIEE8)
  • 亞細(xì)胞定位:
    Cytoplasm. Cell junction, synapse, postsynaptic density.
  • 組織特異性:
    Detected in brain. Detected at low levels in heart.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 14561

    OMIM: 300429

    KEGG: hsa:23229

    STRING: 9606.ENSP00000253401

    UniGene: Hs.54697



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