在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ARHGEF11 Antibody

ARHGEF11 Antibody

  • 中文名稱：
    ARHGEF11兔多克隆抗體
  • 貨號：
    CSB-PA906875
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA906875(ARHGEF11 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA906875(ARHGEF11 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ARHGB_HUMAN antibody; ARHGEF 11 antibody; ARHGEF11 antibody; DKFZp667F1223 antibody; Glutamate transporter EAAT4 associated protein 48 antibody; GTRAP 48 antibody; GTRAP48 antibody; KIAA0380 antibody; OTTHUMP00000038716 antibody; OTTHUMP00000038717 antibody; PDZ RHOGEF antibody; PDZ-RhoGEF antibody; Rho guanine exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor 11 antibody; RhoA specific guanine nucleotide exchange factor antibody; RhoGEF glutamate transport modulator antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Rat
  • 免疫原：
    Synthetic peptide of Human ARHGEF11
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
  • 基因功能參考文獻：
    1. PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF. PMID: 27765920
    2. Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF). PMID: 26522724
    3. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. PMID: 26627240
    4. Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia PMID: 25319871
    5. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. PMID: 24106280
    6. analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF PMID: 21816819
    7. The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population. PMID: 21210224
    8. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein. PMID: 12183458
    9. PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho PMID: 14625312
    10. ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia PMID: 14684465
    11. PDZ-RhoGEF interacts with the actin cytoskeleton PMID: 14742719
    12. This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer. PMID: 16691626
    13. Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. PMID: 17287471
    14. Sequence variation in this gene may influence susceptibility to and risk of type II diabetes. PMID: 17369523
    15. PDZRhoGEF (PRG), mediates RhoA-dependent responses and determines their spatial distribution in differentiated HL60 cells. PMID: 18086913
    16. R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians. PMID: 18231709
    17. the autoinhibition of PRG is caused largely by an interaction of a short negatively charged sequence motif, immediately upstream of the DH-domain. PMID: 19460155
    18. The actin-binding domain of PDZ-RhoGEF, located between amino acids 561 and 585, directly binds to F-actin in vitro and could influence actin structure in a manner independent of its ability to activate RhoA. PMID: 19618964
    19. PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca(2+) signaling to RhoA. PMID: 19759375

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.
  • 組織特異性：
    Ubiquitously expressed.
  • 數據庫鏈接：

    HGNC: 14580

    OMIM: 605708

    KEGG: hsa:9826

    STRING: 9606.ENSP00000357177

    UniGene: Hs.516954



主站蜘蛛池模板： 性色av免费观看| 国产乱女乱子视频在线播放| 青春草在线视频观看| 国产成人一区二区三区别| 亚洲精品国产精品无码国模| 无码福利在线观看1000集| 国产一区二区三区高清在线观看| 人妻丰满被色诱中文字幕| 色狠狠av一区二区三区| 国产jjizz女人多水| 网禁拗女稀缺资源在线观看| 日本大尺度吃奶呻吟视频| 亚洲αⅴ无码乱码在线观看性色| 国产成人亚洲精品无码最新| 亚洲精品国产一区二区的区别| 国产精品后入内射日本在线观看| 在线无码中文字幕一区| 亚洲精品无码成人片久久| 欧美黑吊大战白妞| 久久婷婷五月综合色99啪| 失禁潮痉挛潮喷av在线无码| 国产成人综合在线女婷五月99播放| 精品久久久久久无码人妻vr| 久久久久国产精品免费免费搜索| 国产午夜福利精品一区二区三区| 曰本大码熟中文字幕| 四虎成人国产精品永久在线 | 日本一区二区三区免费高清| 丰满熟妇人妻中文字幕| 国产精品自在自线视频| 99亚洲精品自拍av成人| 狠狠cao日日穞夜夜穞av| 5x性社区免费视频播| 久久久久久无码精品人妻a片软件 999久久久精品国产消防器材 | 四虎一区二区成人免费影院网址| 国产午夜福利精品一区| 毛片内射久久久一区| av淘宝国产在线观看| 久热这里只有精品99| 亚洲熟女综合色一区二区三区 | 免费无码又爽又刺激高潮|