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ARHGEF11 Antibody

  • 中文名稱:
    ARHGEF11兔多克隆抗體
  • 貨號:
    CSB-PA906875
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA906875(ARHGEF11 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA906875(ARHGEF11 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ARHGB_HUMAN antibody; ARHGEF 11 antibody; ARHGEF11 antibody; DKFZp667F1223 antibody; Glutamate transporter EAAT4 associated protein 48 antibody; GTRAP 48 antibody; GTRAP48 antibody; KIAA0380 antibody; OTTHUMP00000038716 antibody; OTTHUMP00000038717 antibody; PDZ RHOGEF antibody; PDZ-RhoGEF antibody; Rho guanine exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor (GEF) 11 antibody; Rho guanine nucleotide exchange factor 11 antibody; RhoA specific guanine nucleotide exchange factor antibody; RhoGEF glutamate transport modulator antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Rat
  • 免疫原:
    Synthetic peptide of Human ARHGEF11
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.
  • 基因功能參考文獻:
    1. PAK4 (but not PAK1) mediates invadopodia maturation during melanoma invasion likely via inhibition of PDZ-RhoGEF. PMID: 27765920
    2. Data show that endothelin A receptor drives invadopodia function by direct interaction of beta-arrestin-1 (beta-arr1) with Rho guanine nucleotide exchange factor (GEF) 11 protein (PDZ-RhoGEF). PMID: 26522724
    3. Two related guanine nucleotide exchange factors (GEFs), PDZ-RhoGEF and leukemia-associated RhoGEF (LARG), use their PDZ domains to bind class B plexins and play critical roles in signaling. PMID: 26627240
    4. Results provide new evidence that ARHGEF11 may constitute a risk factor for schizophrenia PMID: 25319871
    5. Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study. PMID: 24106280
    6. analysis of molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF PMID: 21816819
    7. The R1467H polymorphism of ARHGEF11 gene may contribute to susceptibility to type 2 diabetes mellitus and insulin resistance in a Chinese population. PMID: 21210224
    8. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho-GEF(LARG) and this protein. PMID: 12183458
    9. PDZ-RhoGEF interacts directly with p21-activated kinase 4 to negatively regulate the activation of Rho PMID: 14625312
    10. ARHGER11 is involved in the pathologic changes associated with decreased glutamatergic neurotransmission in schizophrenia PMID: 14684465
    11. PDZ-RhoGEF interacts with the actin cytoskeleton PMID: 14742719
    12. This is the first epidemiological study to link PDZ-RhoGEF polymorphisms with cancer risk, specifically in Mexican Americans at risk for lung cancer. PMID: 16691626
    13. Variation within ARHGEF11 nominally increases risk of type 2 diabetes, possibly as a result of increased insulin resistance. PMID: 17287471
    14. Sequence variation in this gene may influence susceptibility to and risk of type II diabetes. PMID: 17369523
    15. PDZRhoGEF (PRG), mediates RhoA-dependent responses and determines their spatial distribution in differentiated HL60 cells. PMID: 18086913
    16. R1467H variant in the rho guanine nucleotide exchange factor 11 (ARHGEF11) is associated with impaired glucose tolerance and type 2 diabetes in German Caucasians. PMID: 18231709
    17. the autoinhibition of PRG is caused largely by an interaction of a short negatively charged sequence motif, immediately upstream of the DH-domain. PMID: 19460155
    18. The actin-binding domain of PDZ-RhoGEF, located between amino acids 561 and 585, directly binds to F-actin in vitro and could influence actin structure in a manner independent of its ability to activate RhoA. PMID: 19618964
    19. PYK2 and PDZ-RhoGEF are necessary for angiotensin II-induced RhoA activation and for Ca(2+) signaling to RhoA. PMID: 19759375

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  • 亞細胞定位:
    Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 14580

    OMIM: 605708

    KEGG: hsa:9826

    STRING: 9606.ENSP00000357177

    UniGene: Hs.516954



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