在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARHGDIB Antibody, Biotin conjugated

  • 中文名稱:
    ARHGDIB兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA002038LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ARHGDIB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    Arhgdib antibody; D4 antibody; D4 GDP dissociation inhibitor antibody; GDIA 2 antibody; GDIA2 antibody; GDID 4 antibody; GDID4 antibody; GDIR2_HUMAN antibody; GDP dissociation inhibitor D4 antibody; LY GDI antibody; Ly-GDI antibody; LYGDI antibody; MGC108926 antibody; RAP1GN1 antibody; Rho GDI 2 antibody; Rho GDI beta antibody; Rho GDI2 antibody; Rho GDP dissociation inhibitor (GDI) beta antibody; Rho GDP dissociation inhibitor 2 antibody; Rho GDP dissociation inhibitor beta antibody; Rho GDP-dissociation inhibitor 2 antibody; Rho-GDI beta antibody; RhoGDI2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Rho GDP-dissociation inhibitor 2 protein (2-86AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Regulates reorganization of the actin cytoskeleton mediated by Rho family members.
  • 基因功能參考文獻:
    1. RhoGDIbeta overexpression led to downregulation of miR-200c, whereas miR-200c was able directly to target 3'-UTR of jnk2mRNA and attenuated JNK2 protein translation, which resulted in attenuation of Sp1mRNA and protein expression in turn, inhibiting Sp1-dependent MMP-2 transcription. PMID: 28846829
    2. Binders to RhoGDI2 as a potential anti-cancer target have been first reported, and their weak interactions were depicted using NMR spectroscopy. PMID: 27721047
    3. Delta19RhoGDIbeta has an apoptosisindependent role in the phorbol 12myristate 13acetate induced differentiation of THP1 cells to macrophages. PMID: 28260067
    4. The caspase-3-cleaved RhoGDIbeta is a possible determinant to promote cancer spreading. PMID: 26919575
    5. Our interpretation of these contradictions is that truncation and/or mutation of RhoGDI2 perturbs its conformation to expose a site that adventitiously binds FLNA and is not a bona-fide interaction. PMID: 26707877
    6. Results show that RhoGDI2 suppresses bladder cancer metastatic colonization via negative regulation of RhoC activity, providing a rationale for the development of therapeutics that target RhoC signaling. PMID: 25516960
    7. These findings indicate that RhoGDI2 repressed the activity of Rac1 and may be involved in the rearrangement of cytoskeleton in lung cancer cells. PMID: 25562149
    8. Short hairpin RNA-mediated knockdown of RhoGDI2 induces the invasion and migration of lung cancer due to cross-talk with the PI3K/Akt pathway and MMP-9. PMID: 25266803
    9. RhoGDI2 overexpression is associated with tumor growth, metastasis, and chemoresistance in gastric cancer. PMID: 24721928
    10. Depletion of RhoGDI2 expression inhibits the ability of invasion and migration in pancreatic carcinoma. PMID: 24788627
    11. RhoGDI2 inhibits trophoblast cell migration, and this function may involve suppression of RAC1 activation. PMID: 24554735
    12. 14-3-3sigma is a RhoGDI2-regulated gene that appears to be important for suppressing the chemoresistance of gastric cancer cells. PMID: 24185104
    13. These results suggest that RhoGDIbeta has mitotic functions, including regulation of cytokinesis and bipolar spindle formation PMID: 23232495
    14. Rictor regulates cell migration by suppressing RhoGDI2. PMID: 22777355
    15. RhoGDI2 becomes rapidly phosphorylated at Ser31 in response to phorbol 12-myristate 13-acetate stimulation. Conventional type PKCalpha is responsible for this phosphorylation. PMID: 22469974
    16. Expression of ARHGDIB variants 6a, 6b, and 6c appears to be restricted to cancer cells and normal placental tissue, suggesting that these variants possess cancer-specific functions. PMID: 23206989
    17. The ARHGDIB is a lymphoid-specific intrinsic negative regulator of HIV-1 replication that acts by simultaneously inhibiting RhoA and Rac1 functions. PMID: 21936715
    18. Results suggest that D4-GDI may function as a biphasic regulator of breast cancer progression and metastasis. PMID: 22674302
    19. We delineate the mechanism by which RhoGDI2 promotes gastric cancer cell invasion and chemoresistance. In total, 47 differential protein spots were identified; 33 were upregulated, and 14 were downregulated by RhoGDI2 overexpression. PMID: 22364609
    20. RhoGDI2 suppresses lung metastasis in mouse models by reducing the expression of isoforms V1 and V3 of the proteoglycan versican. RhoGDI2 suppressed metastasis by altering inflammation in the tumor microenvironment. PMID: 22406535
    21. Overexpression of RhoGDI2 correlates with tumor progression in colorectal carcinoma. PMID: 21861235
    22. activation of the Src family members and downstream signalling proteins are associated with a good prognosis in transitional cell carcinoma of the bladder, and activated Src has a positive relationship with RhoGD12. PMID: 22353809
    23. PLCgamma plays a key role in RhoGDI2-mediated cisplatin resistance and cell invasion in gastric cancer cells. PMID: 21986528
    24. identification of LyGDI as a binding partner of SHIP, associating inducibly with the SHIP/Grb2/Shc complex PMID: 21695085
    25. This study has revealed that Rho GDP-dissociation inhibitor 2, Y-box binding protein 1, and the HSP70/90 organizing protein have a critical role to play in resistance to cyclin-depedent kinases inhibitor. PMID: 21067243
    26. RhoGDI2 is likely to be involved in lung tumor malignancy and metastasis. PMID: 20596634
    27. High LyGDI serum levels are associated with ovarian cancer. PMID: 20375790
    28. RhoGDI2 is associated with c-Src in bladder tumors, where the expression of both is diminished as a function of stage. c-Src binds to and phosphorylates RhoGDI2 resulting in enhanced metastasis suppressive potency. Review. PMID: 20013033
    29. These data suggest that D4-GDI of Rho family GTPase may be regulated during apoptosis through the caspase-3 mediated cleavage of the GDI protein. PMID: 11989976
    30. Results demonstrate that modification of Rho guanine nucleotide dissociation inhibitor (GDI) 2 during apoptosis is often accompanied by their relocalisation between cellular compartments [Rho GDI 2 ] PMID: 12203895
    31. the interaction of Vav1 and Ly-GDI creates a fine tuning mechanism for the regulation of intracellular signaling pathways leading to NFAT stimulation PMID: 12386169
    32. RhoGDI2 has a role in progression of bladder cancer PMID: 15173088
    33. RhoGDI2 may be implicated in the progress of malignancy. PMID: 17487395
    34. One gene identified by microarray gene expression analysis, RhoGDI2, was tested and confirmed to be metastasis supressor gene; results from cells expressing RhoG-two molecular effectors of RhoGDI2 signaling were identified: endothelin-1 and Neuromedin U. PMID: 17826660
    35. Rho-GDI beta has two roles: one that suppresses tumor progression by inhibiting migration and the other that stimulates it by enhancing Cox-2 expression PMID: 18006811
    36. D4-GDI with two mutations (V68L & V69A) inhibited GDP dissociation from Rho in a dominant negative manner. It accelerates invasion via regulation of cytoskeletal machinery. PMID: 18037226
    37. Transgenic mice with T cell-specific expression display altered cellular immunity against cytozoic pathogens PMID: 18689726
    38. Overexpression of D4-GDI is associated with breast cancer. PMID: 19269969
    39. RhoGDI2 metastasis inhibition works through Rho GTPases but via a mechanism distinct from inhibition of membrane association. PMID: 19276387
    40. phosphorylation by Src enhances RhoGDI2 metastasis suppression and loss of Src relieves metastasis suppression in tumor cells that maintain RhoGDI2 expression. PMID: 19321744
    41. RhoGDI2 is involved in gastric tumor growth and metastasis, and that RhoGDI2 may be a useful marker for tumor progression of human gastric cancer. PMID: 19351766
    42. Results show that the established nerve invasion model and the consensus signature of perineural invasion could be instrumental in the identification of novel therapeutic targets of pancreatic cancer as exemplified by KIF14 and ARHGDIbeta. PMID: 19509238

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    Rho GDI family
  • 組織特異性:
    Detected in bone marrow, thymus and spleen.
  • 數據庫鏈接:

    HGNC: 679

    OMIM: 602843

    KEGG: hsa:397

    STRING: 9606.ENSP00000228945

    UniGene: Hs.504877



主站蜘蛛池模板: 无码喷水一区二区浪潮av| 精品国产杨幂在线观看| 欧美韩中文精品有码视频在线 | 一性一交一口添一摸视频| 777奇米四色成人影视色区| 鲁一鲁一鲁一鲁一曰综合网| 被黑人猛躁10次高潮视频| 国产手机在线αⅴ片无码观看| 国产欧美va欧美va香蕉在线观看 | 日韩在线永久免费播放| 国产精品美女久久久久久福利| 久久精品水蜜桃av综合天堂| 国产午夜亚洲精品不卡在线观看| 亚洲妇女水蜜桃av网网站| 被窝影院午夜无码国产| 免费国产裸体美女视频全黄| 国产肥白大熟妇bbbb| 亚洲色无码专线精品观看| 曰批全过程免费视频观看软件潮喷| 中国美女毛茸茸撒尿| 亚洲精品无码久久久久久久| 少妇夜夜春夜夜爽试看视频| 高清无码爆乳潮喷在线观看 | 色欲天天婬色婬香综合网完整版| 久久综合给久久狠狠97色| 2022国产成人精品视频人| 强行交换配乱婬bd| 国产麻豆精品福利在线| 国产女女做受ⅹxx高潮| 国产麻豆剧传媒精品av| 无码熟熟妇丰满人妻啪啪| 亚洲综合久久无码色噜噜| 性色做爰片在线观看ww| 很色很爽很黄裸乳视频| 国产午夜成人av在线播放| 日本妇人成熟免费中文字幕| 丰满多毛少妇做爰视频爽爽和 | 亚洲精品无码不卡在线播放he | 18禁在线永久免费观看| 免费无码a片一区二三区| 亚洲成a人片在线观看的电影|