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  4. ARHGAP10 Antibody

ARHGAP10 Antibody

  • 中文名稱：
    ARHGAP10兔多克隆抗體
  • 貨號：
    CSB-PA002012GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ARHGAP10
  • 別名：
    Arhgap10 antibody; Graf-related protein 2 antibody; GRAF2 antibody; GTPase regulator associated with focal adhesion kinase 2 antibody; PS GAP antibody; PSGAP antibody; RHG10_HUMAN antibody; Rho GTPase-activating protein 10 antibody; Rho-type GTPase-activating protein 10 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Human ARHGAP10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
  • 基因功能參考文獻：
    1. ARHGAP10 may serve as a tumor suppressor through inactivating Cdc42, as well as inhibiting cell cycle, replication and BER pathways. PMID: 27010858
    2. In the Australian GWAS, one SNP achieved genomewide significance (p < 5 x 10(-8)) for ND (rs964170 in ARHGAP10 on chromosome 4, p = 4.43 x 10(-8)). PMID: 20158304
    3. PS-GAP is a novel regulator of caspase-activated PAK-2 PMID: 15471851
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, perinuclear region. Cell membrane.
  • 組織特異性：
    High levels of expression in heart and skeletal muscle.
  • 數據庫鏈接：

    HGNC: 26099

    OMIM: 609746

    KEGG: hsa:79658

    STRING: 9606.ENSP00000336923

    UniGene: Hs.368631



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