在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARFGEF2 Antibody

  • 中文名稱:
    ARFGEF2兔多克隆抗體
  • 貨號:
    CSB-PA206523
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from A549 cells, using ARFGEF2 antibody.
    • Immunofluorescence analysis of A549 cells, using ARFGEF2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ARFGEF2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human ARFGEF2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.
  • 基因功能參考文獻:
    1. Both phospholipase D activity and vesicular trafficking were required for effects of BIG1 and BIG2 on beta-catenin activation. Levels of PKA-phosphorylated beta-catenin S675 and beta-catenin association with PKA, BIG1, and BIG2 were also diminished after BIG1/BIG2 depletion. PMID: 27162341
    2. Description of a novel ARFGEF2 mutation in five related patients presenting with West syndrome, microcephaly, periventricular heterotopia and thin corpus callosum. PMID: 23812912
    3. The clinical phenotype associated with mutations in ARFGEF2 is relatively homogeneous in the families report. PMID: 23755938
    4. Arf guanine nucleotide-exchange factors BIG1 and BIG2 regulate nonmuscle myosin IIA activity by anchoring myosin phosphatase complex. PMID: 23918382
    5. an early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum. PMID: 23386609
    6. Brefeldin A-inhibited ADP-ribosylation factor activator BIG2 regulates cell migration via integrin beta1 cycling and actin remodeling. PMID: 22908276
    7. Up-regulation of ARFGEF2 is associated with the Huntington's disease. PMID: 21309479
    8. BIG1 and BIG2 have roles in endomembrane organization PMID: 20360857
    9. involvement in molecular mechanisms of vesicular transport PMID: 11665623
    10. identification of protein kinase A-anchoring domains PMID: 12571360
    11. BIG2 and Exo70 interact in trans-Golgi network and centrosomes, as well as in exocyst structures or complexes that move along microtubules to the plasma membrane. PMID: 15705715
    12. ARFGEF2 mRNA was widely expressed in all cortical layers, especially in the neural precursors of the ventricular and subventricular zones during development, with persistent but diminished expression in adulthood. PMID: 16320251
    13. Regulates the constitutive release of tumor necrosis factor receptor type 1 exosome-like vesicles from vascular endothelial cells. PMID: 17276987
    14. Phosphorylation of BIG1 and BIG2 via PKA and protein phosphatase 1gamma effects vesicular trafficking via alterations in ARF activation. PMID: 17360629
    15. COPII is the only coat required for sorting and export from the endoplasmic reticulum exit sites, whereas GBF1 but not BIGs, is required for COPI recruitment, Golgi subcompartmentalization, and cargo progression to the cell surface. PMID: 18003980
    16. These observations indicate that BIG2 and BIG1 play redundant roles in trafficking between the trans-Golgi network and endosomes that involves the AP-1 complex. PMID: 18417613
    17. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701
    18. Results describe a child with a severe choreadystonic movement disorder, bilateral periventricular nodular heterotopia (BPNH), and secondary microcephaly based on compound heterozygosity for two new ARFGEF2 mutations. PMID: 19384555

    顯示更多

    收起更多

  • 相關疾病:
    Periventricular nodular heterotopia 2 (PVNH2)
  • 亞細胞定位:
    Cytoplasm. Membrane. Golgi apparatus. Cytoplasm, perinuclear region. Golgi apparatus, trans-Golgi network. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, dendrite. Cytoplasmic vesicle. Cell junction, synapse. Cytoplasm, cytoskeleton. Note=Translocates from cytoplasm to membranes upon cAMP treatment. Localized in recycling endosomes.
  • 組織特異性:
    Expressed in placenta, lung, heart, brain, kidney and pancreas.
  • 數據庫鏈接:

    HGNC: 15853

    OMIM: 605371

    KEGG: hsa:10564

    STRING: 9606.ENSP00000360985

    UniGene: Hs.62578



主站蜘蛛池模板: 男女裸交免费无遮挡全过程 | 黑人大荫道bbwbbb高潮潮喷| 欧美一区二区三区| 精品少妇人妻av免费久久久| 精品av国产一二三四区| 国产精品视频一区二区亚瑟| 又爽又黄无遮挡高潮视频网站| 欧美日韩亚洲国产在线制服| 欧美顶级少妇做爰hd| 国产尤物精品视频| 免费1级a做爰片观看| 亚洲日韩穿丝袜在线推荐| 蜜柚av久久久久久久| 影音先锋中文字幕人妻| 欧洲熟妇色xxxx欧美老妇| 久久五十路丰满熟女中出| 国产亚洲另类无码专区| 青草青草视频2免费观看| 人妻少妇精品视频一区二区三区| 欧美综合自拍亚洲综合图片区| 亚洲中文有码字幕日本第一页| 精品亚洲卡一卡2卡三卡乱码| 内射女校花一区二区三区| 免费欧洲美女牲交视频| 精品久久久无码中文字幕边打电话| 夜色约爱网站| 成·人免费午夜视频香蕉| 久久亚洲精品成人av| 国产成a人亚洲精v品无码| 久热在线这里只有精品国产| 亚洲国产成人综合在线不卡| 制服丝袜中文字幕在线| 亚洲熟妇色xxxxx欧美老妇| 成人av久久一区二区三区| 亚洲精品久久久久久动漫| 久久丫精品国产| 日本久久综合久久综合| 亚洲va综合va国产产va中| 国产成年无码久久久久下载| 欧美人与禽猛交狂配| 欧美性xxxx极品hd欧美风情|