在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ARFGAP1 Antibody

  • 中文名稱:
    ARFGAP1兔多克隆抗體
  • 貨號:
    CSB-PA001997GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ADP ribosylation factor 1 GTPase activating protein antibody; ADP ribosylation factor GTPase activating protein 1 antibody; ADP-ribosylation factor 1 GTPase-activating protein antibody; ADP-ribosylation factor GTPase-activating protein 1 antibody; ARF GAP 1 antibody; ARF1 directed GTPase activating protein antibody; ARF1 GAP antibody; ARF1-directed GTPase-activating protein antibody; ARF1GAP antibody; ARFG1_HUMAN antibody; Arfgap1 antibody; GAP protein antibody; HRIHFB2281 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ARFGAP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine.
  • 基因功能參考文獻:
    1. ARFGAP1 is found associated with lipid droplets at steady state in some but not all hepatocytes. PMID: 25397679
    2. ARFGAP1 is a host factor for Hepatitis C Virus RNA replication, and is hijacked by HCV NS5A to remove COPI cargo Sac1 from the site of HCV replication to maintain high levels of PI4P. PMID: 24623438
    3. ArfGAP1 is identified as the first GTPase activating protein (GAP) for leucine-rich repeat kinase 2 (LRRK2). PMID: 22423108
    4. role of ARFGAP1 in AP-2-regulated endocytosis has mechanistic parallels with its roles in COPI transport, as both its GAP activity and coat function contribute to promoting AP-2 transport PMID: 21499258
    5. The small GTPases of the Ras superfamily mediate numerous biological processes through their ability to cycle between an inactive GDP-bound and an active GTP-bound form. PMID: 15246431
    6. ArfGAP1 interacts with the Golgi through multiple hydrophobic motifs and that alternative modes of interaction may exist in tissue-specific ArfGAP1 isoforms. PMID: 16316994
    7. SMAP2 functions in the retrograde, early endosome-to-trans golig network pathway in a clathrin- and AP-1-dependent manner. PMID: 16571680
    8. coatomer is an allosteric regulator of Arf GAP1 PMID: 18541532
    9. Differential roles of ArfGAP1, ArfGAP2, and ArfGAP3 in COPI trafficking PMID: 19015319
    10. catalytic amounts of Arf1GAP1 significantly reduce the yield of purified COPI vesicles PMID: 19055691
    11. ArfGAP1, ArfGAP2, and ArfGAP3 have overlapping roles in regulating COPI function in Golgi-to-ER retrograde transport. PMID: 19299515

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Golgi apparatus.
  • 數據庫鏈接:

    HGNC: 15852

    OMIM: 608377

    KEGG: hsa:55738

    STRING: 9606.ENSP00000314615

    UniGene: Hs.25584



主站蜘蛛池模板: 真人做人试看60分钟免费视频 | 国产精品无码久久综合| 人妻去按摩店被黑人按中出| 开心五月色婷婷综合开心网| 激情射精爆插热吻无码视频| 久久久久久久曰本精品免费看| 欧美熟妇色ⅹxxx欧美妇| 欧美成人看片黄a免费看| 亚洲精品国产成人一区二区| 99久e在线精品视频在线| 男女啪啪进出阳道猛进| 无码av大香线蕉| 国产桃色无码视频在线观看 | 伊人99综合精品视频| 吸咬奶头狂揉60分钟视频| 中文字幕丰满孑伦无码精品| 大香伊蕉在人线免费视频| 色婷婷五月综合色啪网| 亚洲夜夜性无码| 鲁丝片一区二区三区毛片| 人妻少妇精品无码专区芭乐视网 | 亚洲婷婷开心色四房播播| 18禁免费吃奶摸下激烈视频| 狠狠色综合激情丁香五月| 无码熟妇人妻av在线影片最多| 国产亚洲精品久久久ai换脸| 午夜成人无码福利免费视频| 亚洲欧美日韩精品色xxx| 亚洲国产99精品国自产拍| 69国产精品久久久久久人妻| 深夜福利视频在线播放| 无码尹人久久相蕉无码| 精品无码一区在线观看| 五月天激情国产综合婷婷婷| 午夜精品久久久久久久爽| 国产精品青青在线观看爽| 浓毛欧美老妇乱子伦视频 | 欧美乱大交aaaa片if| 香蕉视频在线精品视频| 狠狠热精品免费视频| 亚洲综合久久精品无码色欲|