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APRT Antibody

  • 中文名稱:
    APRT兔多克隆抗體
  • 貨號:
    CSB-PA001954DSR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA001954DSR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) APRT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    APRT
  • 別名:
    Adenine phosphoribosyltransferase antibody; AMP antibody; AMP diphosphorylase antibody; AMP pyrophosphorylase antibody; APRT antibody; APT_HUMAN antibody; DKFZp686D13177 antibody; MGC125856 antibody; MGC125857 antibody; MGC129961 antibody; Transphosphoribosidase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Adenine phosphoribosyltransferase protein (1-180AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  • 基因功能參考文獻:
    1. A long TA repeat in the promoter region of IL28B was associated with spontaneous HCV clearance. PMID: 25735432
    2. A new mutation, p.Gln147X, in APRT gene, was found in a patient with adenine phosphoribosyltransferase deficiency. PMID: 24986359
    3. Case study of 2 year old Japanese boy with APRT deficiency. Genetic analysis showed compound heterozygote APRT*J and missense mutation L33P. APRT deficiency should be suspected in patients with radiolucent kidney stones and urinary 2,8-DHA crystals. PMID: 21635362
    4. kinetic, regulatory and thermostability properties of APRT from erythrocytes of HGPRT deficient patients PMID: 14674717
    5. determination of structure and examination of role of deficiency in DHA-urolithiasis PMID: 15196008
    6. two novel mutations, G133D and V84M, were found in the APRT gene in Japanese patients with APRT deficiency PMID: 15571218
    7. APRT assay in a sample of patient hemolysate showed no detectable activity of the enzyme (25.56+/-9.55 U/L red blood cells in control healthy subjects). PMID: 17126311
    8. Data indicates that the flexible loop structure adopts an open conformation before and after binding of both substrates adenine and phosphoribosyl pyrophosphate. PMID: 18399692
    9. The phosphorylation status of membrane-bound nucleoside diphosphate kinase in epithelia and the role of AMP are reported. PMID: 19399589

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  • 相關疾病:
    Adenine phosphoribosyltransferase deficiency (APRTD)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Purine/pyrimidine phosphoribosyltransferase family
  • 數據庫鏈接:

    HGNC: 626

    OMIM: 102600

    KEGG: hsa:353

    STRING: 9606.ENSP00000367615

    UniGene: Hs.28914



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