在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

APOC2 Antibody

  • 中文名稱:
    APOC2兔多克隆抗體
  • 貨號:
    CSB-PA001932OA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • IHC image of CSB-PA001932OA01HU diluted at 1:500 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) APOC2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    APC 2 antibody; APC2 antibody; Apo CII antibody; Apo-CII antibody; APOC 2 antibody; ApoC II antibody; ApoC-II antibody; APOC2 antibody; APOC2 protein antibody; APOC2_HUMAN antibody; ApoCII antibody; Apolipoprotein C II antibody; Apolipoprotein C II precursor antibody; Apolipoprotein C2 antibody; ApolipoproteinCII antibody; MGC75082 antibody; ProapoC-II antibody; Proapolipoprotein C-II antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Peptide sequence from Human Apolipoprotein C-II protein (20-38AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產(chǎn)品,APOC2 Antibody (CSB-PA001932OA01HU),的標記方式是Non-conjugated。對于APOC2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA001932OB01HU APOC2 Antibody, HRP conjugated ELISA
    FITC CSB-PA001932OC01HU APOC2 Antibody, FITC conjugated
    Biotin CSB-PA001932OD01HU APOC2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
  • 基因功能參考文獻:
    1. Results from this exploratory analysis suggest that regulatory element methylation levels within the larger TOMM40-APOE-APOC2 gene region correlate with AD-related biomarkers and TOMM40 or APOE gene expression in AD. PMID: 29371683
    2. Triglyceride-raising variant alleles of the APOC2 encoding apo C-II, associated with clinical Cardiovascular endpoints. PMID: 28534127
    3. The results demonstrate the important role of both intra- and inter-subunit charge interactions in stabilizing apoC-II amyloid fibrils, a process that may be a key factor in determining the general ability of proteins to form amyloid fibrils. PMID: 28229588
    4. The results highlight the importance of charge-pair interactions within the apoC-II fibril core PMID: 26196342
    5. Conformational rearrangement of apoC-II at lipoprotein surfaces promotes interaction with LPL. PMID: 26026161
    6. Large deletion in APOC2 caused by Alu-Alu homologous recombination is associated with with apolipoprotein C-II deficiency. PMID: 25172036
    7. No APOC2 mutations were identified in a cohort of patients with diabetic lipemia. PMID: 25131724
    8. STAT1 bound on multienhancer 2 cooperates with RXRalpha located on apoCII promoter and upregulates apoCII expression only in macrophages. PMID: 22808166
    9. Mutations in GPIHBP1 are rare but the associated clinical phenotype of hypertriglyceridaemia is severe PMID: 22239554
    10. These results support a predictive change in the ratio of plasma ApoCIII to ApoCII in pregnancies complicated by severe preeclampsia. PMID: 21321243
    11. Substoichiometric concentrations of cyc[60-70] significantly delayed fibril formation by the fibrillogenic, linear peptides apoC-II[60-70] and apoC-II[56-76]. PMID: 22244853
    12. Activation of apoC-II fibrils by submicellar lipid (NBD-lyso-12-phosphocholine) is catalytic with release of monomer- and tetramer-bound lipid accompanying fibril elongation and growth. PMID: 21985034
    13. Physiological shear flow conditions and conditions experienced during apoC-II manufacturing exert significant effects on apoC-II conformation, leading to protein misfolding, aggregation, and amyloid fibril formation. PMID: 21476595
    14. Includes the observation of APOC4-APOC2 read-through transcription PMID: 8530039
    15. Our structural model for apoC-II fibrils suggests that apoC-II monomers fold and self-assemble to form a stable cross-beta-scaffold containing relatively unstructured connecting loops. PMID: 21146539
    16. Results describe the functional role of the secondary structure in the lipoprotein lipase-binding portion of apolipoprotein CII. PMID: 20042600
    17. Human apolipoprotein C-II (apoC-II) slowly forms amyloid fibers in lipid-free solutions at physiological pH and salt concentrations PMID: 11751863
    18. During amyloidosis under oxidizing conditions, cysteine-containing apolipoprotein C-II (apoC-II) derivatives form fibrils more rapidly and become extensively tangled compared to wild-type apoC-II. PMID: 12450397
    19. Three categories of global constraints, together with the local classical NMR constraints, define the 3D structure of the apoCII-SDS micelle complex and give important clues toward a possible mechanism for the activation of lipoprotein lipase by apoCII. PMID: 12590574
    20. regions of lipoprotein lipase that are responsive to activation by apoC-II PMID: 12682050
    21. Hydrolysis activated by APOC2 was faster compared with the LPL-mediated lipolysis of emulsion triolein. The binding density of APOC2 was less for small emulsion surfaces than for large ones. PMID: 12782148
    22. Different levels of secreted apoC-II had little effect on LDL and HDL protein degradation by HepG2 cells. Compared to controls, cells under-expressing apoC-II showed a 160% higher capacity to selectively take up HDL-CE. PMID: 15778093
    23. Results show that purified human HDL and recombinant apolipoprotein A-I lipid particles bind directly to amyloid beta and apolipoprotein C-II amyloid fibrils. PMID: 16432277
    24. No relationship was found between ApoCII polymorphism and coronary disease in the Chinese Han population. PMID: 16459141
    25. Decrease of LPL activity in the heart, along with the inhibitory effects of excess apolipoprotein C-II, may contribute to the hypertriglyceridemia observed in apolipoprotein c-ii transgenic mice. PMID: 17018885
    26. Taken together these data demonstrate an interaction between antichymotrypsin and apolipoprotein C-II that accelerates fibrillogenesis and indicates a specific role for accessory proteins in protein aggregation. PMID: 17174330
    27. These results suggested that T-->A substitution at position -190 in the apoC-II gene promoter only partly affected transcriptional activity of the apoC-II promoter, leading to decrease of apoC-II expression in quantity. PMID: 17222387
    28. The ozone oxidation product of cholesterol, 3beta-hydroxy-5-oxo-5,6-secocholestan-6-al, rapidly promotes human apolipoprotein (apo) C-II amyloid fibril formation in vitro. PMID: 17429947
    29. Both common and rare DNA variants of APOC2 gene were found in 10% patients with severe hypertriglyceridemia PMID: 17717288
    30. Phospholipid interaction induces molecular-level polymorphism in APOC2 amyloid fibrils via alternative assembly pathways. PMID: 18005990
    31. The concentration-dependent kinetics of apolipoprotein C-II amyloid fibril formation and correlated this with the final size distribution of the fibrils determined by sedimentation velocity experiments, is studied. PMID: 18206908
    32. lipids promote on-pathway intermediates of apoC-II fibril assembly and the accumulation of a discrete tetrameric intermediate depends on the molecular state of the lipid PMID: 18852267
    33. No significant differences were found between the acute hypertriglyceridaemic pancreatitis cases and controls with severe hypertriglyceridaemia in terms of LPL activity and mass, hepatic lipase activity, CII and CIII mass, or apo E polymorphisms. PMID: 19534808

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Hyperlipoproteinemia 1B (HLPP1B)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Apolipoprotein C2 family
  • 組織特異性:
    Liver and intestine.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 609

    OMIM: 207750

    KEGG: hsa:344

    STRING: 9606.ENSP00000466775

    UniGene: Hs.75615



主站蜘蛛池模板: 伊人久久大香线蕉av波多野结衣| 欧美性猛交ⅹxxx乱大交妖精| 国产亚洲精品a在线无码| 日韩中文高清在线专区| 综合精品欧美日韩国产在线| 永久免费看啪啪网址入口| 午夜福利视频| 亚洲精品国产嫩草在线观看东京热| 又爆又大又粗又硬又黄的a片| 99re在线播放| 97在线视频人妻无码| 99久久久无码国产精品动漫| 自偷自拍亚洲综合精品麻豆| 无码人妻av免费一区二区三区| 高h纯肉无码视频在线观看| 亚洲精品综合一区二区三区在线| 玩50岁四川熟女大白屁股直播| 久久久久久a亚洲欧洲av冫| 久久久久有精品国产麻豆| 永久久久免费人妻精品| 好男人在线社区www在线影院| 国产精品99久久精品爆乳| 精品国精品自拍自在线| 亚洲精品无码不卡av| 色综亚洲国产vv在线观看| 久久精品国产精品青草| 日日摸夜夜摸狠狠摸婷婷| 亚洲国产精品福利片在线观看| 国产精品www夜色视频| 亚洲欧洲无码av电影在线观看| 亚洲熟女av乱码在线观看漫画| 亚洲婷婷综合色高清在线| 精品成人免费一区二区不卡| 欧美伦费免费全部午夜最新| 免费无码毛片一区二区三区a片| 少妇人妻综合久久中文字幕| 一本色道久久东京热| 大地资源在线观看官网第三页| 日本丰满白嫩大屁股ass| 国产成人高清精品免费| 柠檬福利第一导航在线|