在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

APLP1 Antibody

  • 中文名稱:
    APLP1兔多克隆抗體
  • 貨號:
    CSB-PA004677
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of K562 cells using APLP-1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    APLP1
  • 別名:
    APLP1; Amyloid beta precursor like protein 1; Amyloid beta; A4 precursor-like protein 1; Amyloid-like protein 1; APLP; APLP-1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human APLP-1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.; The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.
  • 基因功能參考文獻:
    1. The direct cleavage of APLP1 is a novel feature of the gamma-secretase. PMID: 29382944
    2. Results provide direct evidence that APLP1 functions as a neuronal zinc-dependent adhesion protein and allow a more detailed understanding of the molecular mechanisms driving the formation of APLP1 adhesion platforms. PMID: 29021345
    3. The results show that in cognitively normal young adults carrying APlp1 mutations showed different spontaneous brain activity patterns without cerebral structural differences. PMID: 28987665
    4. These data reveal a conserved mechanism for the binding of APP-family proteins to HS and imply a specific regulatory role of HS modifications in the biology of APP and APP-like proteins. PMID: 25760599
    5. APLP1 and APLP2, behave similarly to APP in that they both associate with assembled NMDA receptors in the endoplasmic reticulum PMID: 25683482
    6. CSF levels of 3 endogenous peptides derived from APLP1 (APL1beta25, APL1beta27 and APL1beta28) were decreased in Down syndrome. PMID: 24740518
    7. APLP1 has a regulatory role in the nuclear translocation of APP family intracellular domains due to the sequestration of Fe65. PMID: 23874953
    8. [review] APP and its mammalian homologs, amyloid precursor-like proteins APLP1 and APLP2, participate under physiological conditions via trans-cellular dimerization in synaptogenesis. PMID: 21952790
    9. APLP1 binds the II-III loop of the Ca(v)2.3 calcium channel and that this binding promotes internalization of the channel. PMID: 22178872
    10. Both APLP1 and APLP2, form transcriptionally active triple protein complexes with Mint3 and transcriptional co-activators Taz andYap. PMID: 21178287
    11. The 2.1 A resolution electron density map reveals phosphate ions that are bound to the protein surface. Mutational analysis shows that protein residues interacting with the phosphate ions are also involved in heparin binding. PMID: 21574595
    12. Human cerebrospinal fluid contains three APLP1-derived Abeta-like peptides that are generated by beta- and gamma-cleavages at a concentration of approximately 4.5 nM. PMID: 20049724
    13. APLP1 and APLP2 are processed by the gamma-secretase in a Presenilin 1-dependent manner and the extreme carboxyl-terminal fragments produced by this processing (APP-like Intracellular Domain) are able to enhance Fe65-dependent gene activation PMID: 12228233
    14. APLP1 does not undergo the same type of regulated processing as APP and APLP2. PMID: 14597230
    15. APLP1 and APLP2 and APP are processed similarly to act via the same nuclear target and are regulated by BACE 1 in neurons PMID: 14699153
    16. APLP-1 and APLP-2 are processed by alpha- and gamma-secretase-like cleavages, and their intracellular domains can be released by cleavage at epsilon-sites. APLP-2 processing appears to be the most elaborate and to involve alternative cleavage sites. PMID: 14970212
    17. The 5' UTR of the Aplp1 gene lacks any type of CAGA box. This may explain its inability to form amyloid plaques. PMID: 15208260
    18. APLP1 affects the endocytosis of APP and makes more APP available for alpha-secretase cleavage PMID: 16344553
    19. APLP1 is differentially upregulated in gastrointestinal neuroendocrine tumours and may be important for the dissemination of small intestinal carcinoids PMID: 18430897
    20. Coexpression of APP with APLP1 or APLP2 leads to diminished generation of Abeta42 PMID: 19126676
    21. neither cell-derived nor chemically synthesized APLP1-derived peptide influences the oligomerization or aggregation of Abeta PMID: 19401174

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.; [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex.
  • 蛋白家族:
    APP family
  • 組織特異性:
    Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).
  • 數據庫鏈接:

    HGNC: 597

    OMIM: 104775

    KEGG: hsa:333

    STRING: 9606.ENSP00000221891

    UniGene: Hs.74565



主站蜘蛛池模板: 97影院在线午夜| 亚洲综合无码一区二区| 97人妻人人做人碰人人爽| 久久精品国产99久久香蕉| 女人被躁到高潮免费视频软件| 国产狂喷潮在线观看中文| 99久久精品无码一区二区三区| 无码人妻一区二区三区免费视频 | 婷婷五月日韩av永久免费| 99久久超碰中文字幕伊人| 欧美群交射精内射颜射潮喷| 欧美成人精品高清视频在线观看| 国产精品黄页免费高清在线观看| 久久无码精品一一区二区三区| 久久精品久久久久观看99水蜜桃| 国产农村妇女精品一二区| 激情射精爆插热吻无码视频| 国产av无码精品色午夜| 成人综合婷婷国产精品久久蜜臀 | 欧美gv在线观看| 日日天日日夜日日摸| 小嫩妇好紧好爽18禁视频| 激情五月综合色婷婷一区二区| 国内精品视这里只有精品| 俺去啦俺来也五月天| 免费观看美女裸体网站| 熟睡人妻被讨厌的公侵犯深田咏美| 丁香婷婷无码不卡在线| 国产精品久久久久无码av1| 国产伦理一区二区| 亚洲日韩成人性av网站| 手机在线亚洲国产精品| 国产a∨精品一区二区三区不卡 | 无码办公室丝袜ol中文字幕| 97午夜理论片在线影院| 国产精品女主播主要上线| 国产精品专区免费观看软件| 少妇特黄a一区二区三区 | 国产午睡沙发被弄醒完整版| 亚洲国产成人无码av在线播放 | 男女真人国产牲交a做片野外 |