在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. APH1B Antibody

APH1B Antibody

  • 中文名稱：
    APH1B兔多克隆抗體
  • 貨號：
    CSB-PA819900NA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate, PC-3 whole cell lysate
      All lanes: APH1B antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 29, 25 kDa
      Observed band size: 29 kDa
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) APH1B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    APH1B; PSFL; UNQ688/PRO1328; Gamma-secretase subunit APH-1B; APH-1b; Aph-1beta; Presenilin-stabilization factor-like
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Peptide sequence from Human Gamma-secretase subunit APH-1B protein (93-110AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，APH1B Antibody (CSB-PA819900NA01HU)，的標記方式是Non-conjugated。對于APH1B Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產(chǎn)品名稱 應用
    HRP CSB-PA819900NB01HU APH1B Antibody, HRP conjugated ELISA
    FITC CSB-PA819900NC01HU APH1B Antibody, FITC conjugated
    Biotin CSB-PA819900ND01HU APH1B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
  • 基因功能參考文獻：
    1. Data show that presenilin 1 (PS1)/anterior-pharynx-defective protein 1 (Aph1b), presenilin 2 (PS2)/Aph1aL, PS2/Aph1aS and PS2/anterior pharynx defective 1 homolog B (Aph1b) gamma-secretase produced amyloid beta peptide (Abeta) with a higher Abeta42+Abeta43-to-Abeta40 (Abeta42(43)/Abeta40) ratio than the other gamma-secretases. PMID: 27608597
    2. gamma-Secretase inhibition during repeated peripheral inflammation blocks central amyloid-beta accumulation and prevents cognitive dysfunction. PMID: 23665252
    3. Expression of APH-1b increases amyloid beta peptide levels and gamma-secretase activity. PMID: 12763021
    4. both APH-1a splice forms and APH-1b are expressed in peripheral and neuronal cells. APH-1aS, APH-1aL, and APH-1b form separate, proteolytically active gamma-secretase complexes containing either one of the two presenilins. PMID: 15286082
    5. dimeric (NCSTN/APH-1) and trimeric (NCSTN/APH-1/PS1) intermediates of gamma-secretase complex assembly are retained within the ER and incorporation of the fourth binding partner (PEN-2) also occurs on immature NCSTN (APH-1) PMID: 15591316
    6. knock down of APH-1a, but not APH-1b, resulted in impaired maturation of nicastrin and reduced expression of presenilin 1, presenilin 2, and PEN-2 proteins PMID: 15629423
    7. APH-1b variant protein is destabilized, and the fourth transmembrane domain plays an important role in the protein stability and function of APH-1. PMID: 15823552
    8. These results collectively indicate that the three forms of APH-1 can replace each other in presenilin (PS) complexes and that the transmembrane GxxxG region is essential for the stability of the APH-1 protein as well as the assembly of PS complexes. PMID: 16757808
    9. These data suggest that a cooperative mechanism involving APOE and APH-1b plays a role in the susceptibility to develop AD. PMID: 17466415
    10. A non-synonymous SNP in the gamma-secretase component APH1B (Phe217Leu; rs1047552)is significantly associated with premature coronary atherosclerosis in Dutch males. PMID: 18987747
    11. The single-nucleotide polymorphism (Phe217Leu; rs1047552) showed a tendency for association with HIV-1 infection in a Xhosa indigenous South African Bantu study (P = 0.087), and associated significantly in a Caucasian Dutch study (P = 0.049). PMID: 19774691

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein.
  • 蛋白家族：
    APH-1 family
  • 組織特異性：
    Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24080

    OMIM: 607630

    KEGG: hsa:83464

    STRING: 9606.ENSP00000261879

    UniGene: Hs.511703



主站蜘蛛池模板： 国产天堂亚洲国产碰碰| 性视频播放免费视频| 精品久久久久中文字幕一区| 亚洲 精品 综合 精品 自拍| 日本精品久久久久中文字幕 | 欧美性猛交xxxx三人| 999久久久精品国产消防器材| 久久久久国产精品人妻电影| 色八区人妻在线视频免费| 老熟女重囗味hdxx70星空| 对白脏话肉麻粗话av| 色偷拍 自怕 亚洲 10p| 欧美日韩精品suv| 欧美极品色午夜在线视频| 精品国产自在现线看久久| 欧美丰满少妇xxxxx| 色偷偷88888欧美精品久久久| 熟妇人妻午夜寂寞影院| 日韩经典精品无码一区| 成人无码专区免费播放三区| 国产乱理伦片在线观看| 无码人妻熟妇av又粗又大| 亚洲熟妇色xxxxx欧美老妇| 女同免费毛片在线播放| 国产精品福利一区二区久久| 乱人伦人妻中文字幕无码久久网| 四虎国产精品永久免费网址| 中文字幕aav| 欲色欲色天天天www| 午夜福利无码不卡在线观看| 久久国产精品99国产精| 国内精品视这里只有精品| 人妻精品动漫h无码网站| 成年无码动漫av片在线尤物网站| 中文字幕在线播放| 97se亚洲国产综合自在线观看| 国产精品亚洲精品日韩己满十八小| 老汉色老汉首页a亚洲| 人妻在线无码一区二区三区| 影视先锋av资源噜噜| 奇米影视777四色狠狠|