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APBB2 Antibody

  • 中文名稱:
    APBB2兔多克隆抗體
  • 貨號:
    CSB-PA009249
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    APBB2
  • 別名:
    Amyloid beta (A4) precursor protein-binding; family B; member 2 (Fe65 like) antibody; Amyloid beta A4 precursor protein binding family B member 2 antibody; Amyloid beta A4 precursor protein-binding family B member 2 antibody; APBB 2 antibody; APBB2 antibody; APBB2_HUMAN antibody; Fe65 like 1 antibody; Fe65 like antibody; Fe65 like protein antibody; FE65L 1 antibody; FE65L antibody; FE65L1 antibody; Protein Fe65-like 1 antibody; Rirl 1 antibody; Rirl1 antibody; TR2 L antibody; TR2L antibody; Zfra antibody; Zinc finger like protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Fe65L.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in the maintenance of lens transparency, and may also play a role in muscle cell strength. Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Activates transcription of APP.
  • 基因功能參考文獻:
    1. APBB2 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
    2. results provide additional evidence of a genetic interaction between GSK3beta and APBB2 and further suggest that GSK3beta is involved in the pathophysiology of both of the primary neuropathologies of Alzheimer's disease PMID: 26194614
    3. The APBB2 rs13133980 G allele was over-represented in centenarians with severe cognitive impairment compared to individuals without this disability. PMID: 23384821
    4. FE65L1 potentiates gamma-secretase processing of APP CTFs. This requires binding of FE65L1 to APP and APP CTFs. Enhanced APP CTF processing can be detected in early endosome vesicles PMID: 14527950
    5. rs13133980 associated significantly with age of onset in Alzheimer disease. Genetic variations in APBB2 may affect late onset AD susceptibility. PMID: 15714520
    6. the apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by TNF PMID: 16083851
    7. In response to TNF, Zfra is upregulated and modulates TNF-mediated cell death via interacting with TRADD, FADD and RIP (death-inducing signaling complex) at the receptor level, and downstream effectors NF-kappaB, p53, WOX1, and JNK1. PMID: 17567906
    8. The hCV1558625 G allele was over-represented in patients with onset under age 70 compared to controls in the same age range. PMID: 18852029
    9. The differential processing of amyloid-beta precursor via secretase enzymes regulates the proliferation and differentiation of human embryonic stem cell. PMID: 19542221

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  • 亞細胞定位:
    Endoplasmic reticulum. Golgi apparatus. Early endosome.
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:

    HGNC: 582

    OMIM: 602710

    KEGG: hsa:323

    STRING: 9606.ENSP00000427211

    UniGene: Hs.479602



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