在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

APBB1 Antibody

  • 中文名稱:
    APBB1兔多克隆抗體
  • 貨號:
    CSB-PA001890ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA001890ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA001890ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) APBB1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    APBB1
  • 別名:
    Adaptor protein FE65a2 antibody; Amyloid beta (A4) precursor protein binding family B member 1 antibody; Amyloid beta A4 precursor protein binding family B antibody; Amyloid beta A4 precursor protein binding family B member 1 antibody; Amyloid beta A4 precursor protein-binding family B member 1 antibody; Amyloid beta precursor protein binding family B member 1 antibody; APBB 1 antibody; APBB1 antibody; APBB1_HUMAN antibody; FE 65 antibody; Fe65 protein antibody; Protein Fe65 antibody; RIR antibody; stat like protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Amyloid beta A4 precursor protein-binding family B member 1 protein (361-710AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Plays a role in the maintenance of lens transparency. May play a role in muscle cell strength.
  • 基因功能參考文獻:
    1. Fe65 is an adaptor protein involved in both processing and signaling of the Alzheimer-associated amyloid-beta precursor protein, APP. Here, the subcellular localization was further investigated using TAP-tagged Fe65 constructs expressed in human neuroblastoma cells. Our results indicate that PTB2 rather than the WW domain is important for the nuclear localization of Fe65. PMID: 28323844
    2. Fe65 Ser289 phosphorylation did not affect the transcriptional activity of the Fe65-APP complex, in contrast to the previously described Ser228 site. PMID: 27176072
    3. Our findings imply that APBB1 plays an important role in the maintenance of EMT-associated CSC-like properties and gamma-radiation resistance via activation of IGF1Rbeta/AKT/GSK3beta pathway in lung cancer cells, highlighting APBB1 as a potential target for therapeutic cancer treatment. PMID: 27836546
    4. Targeted enhancement of the signaling through the Fe65-cortactin pathway, by either HDAC6 inhibition or Tip60 activation, may lead to the development of new therapeutic drugs that are effective for patients with metastatic breast cancers. PMID: 26166158
    5. FE65 influences APP degradation via the proteasome, and phosphorylation of FE65 Ser(610) by SGK1 regulates binding of FE65 to APP, APP turnover and processing. PMID: 26188042
    6. A novel phosphorylation site was identified within Fe65 which mediates gene transcription. PMID: 25397632
    7. The SV2A/FE65 interaction might play a role in synaptic signal transduction. PMID: 24284412
    8. Data indicate that Fe65 is a positive estrogen receptor alpha (ERalpha) transcriptional regulator. PMID: 24619425
    9. FE65 interactions with BLM and MCM proteins may contribute to the neuronal cell cycle re-entry observed in brains affected by Alzheimer's disease. PMID: 23572515
    10. A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1. PMID: 22902274
    11. Both amyloid-beta precursor protein and Fe65 are co-localized in model Hirano bodies associated with Alzheimer's disease. PMID: 20133016
    12. Fe65 carries out different functions depending on its location in the regulation of Notch1 signaling. PMID: 22199353
    13. A novel FE65 isoform and the regulation of the splicing events leading to its production may contribute to elucidating neuronal specific roles of FE65 and its contribution to Alzheimer's disease pathology. PMID: 21824145
    14. Phosphorylation of LRP1 regulates the interaction with Fe65. PMID: 21968187
    15. Fe65 binds preferentially to low-density lipoprotein receptor-related protein (LRP) carboxyl terminus when phosphorylated at tyrosine-4507 and in complex with amyloid precursor protein (APP). PMID: 21650223
    16. Fe65 and Dab1 compete for binding to APP. Dab1 significantly decreased the amount of APP bound to LRP and the level of secreted APP and APP-CTF in LRP expressing cells PMID: 20568118
    17. reduced levels of Sp1 resulted in downregulation of endogenous FE65 mRNA and protein PMID: 20091743
    18. The data of this demonstrated that the induction of AICD/Fe65 or transgelin significantly alters actin dynamics and mitochondrial function in neuronal cells PMID: 20405578
    19. The transcriptional activity of the APP intracellular domain-Fe65 complex is inhibited by activation of the NF-kappaB pathway. PMID: 12653567
    20. Adjusting for age and sex, we found a slight risk associated with the deletion in intron 13 of the APBB1 gene for subjects less than 65 years. PMID: 12727304
    21. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. PMID: 12779321
    22. APP and Fe65 mediate transactivation with low density lipoprotein receptor-related protein PMID: 12888553
    23. Abnormal accumulations of the amyloid-beta precursor protein associated with the aging cellular muscle fibers and appear to be the key pathogenic event in iclusion-body myositis. PMID: 14569203
    24. Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation PMID: 15037614
    25. Fe65 is activated by the APP intracellular domain during transcriptional transactivation PMID: 15044485
    26. p65FE65 may be an intracellular mediator in a signaling cascade regulating alpha-secretion of APP PMID: 15647266
    27. The present work provides evidence that FE65 plays a role in the regulation of amyloid precursor protein processing in an in vivo transgenic mouse model. PMID: 15816856
    28. multiple interactions of AICD with FE65 and 14-3-3gamma modulate FE65-dependent gene transactivation PMID: 16223726
    29. FE65 is the key agent of Gal4DB-mediated transcriptional transactivation, whereas Tip60 is an FE65-associated repressor. PMID: 16332686
    30. Notch1 intracellular domain plays the role of a negative regulator in AICD signaling via the disruption of the AICD-Fe65-Tip60 trimeric complex. PMID: 17368826
    31. Nek6 binds to Fe65 through its (267)PPLP(270) motif; the protein-protein interaction between Nek6 and Fe65 regulates their subcellular localization and cell apoptosis PMID: 17512906
    32. We demonstrated that treatment with EGCG reduced the A beta levels by enhancing endogenous APP nonamyloidogenic proteolytic processing. PMID: 17590240
    33. Results describe the crystal structures of the human FE65 WW domain (residues 253-289) in the apo form and bound to the peptides PPPPPPLPP and PPPPPPPPPL, which correspond to human Mena residues 313-321 and 347-356, respectively. PMID: 17686488
    34. Fe65 regulation of APP proteolysis may be integrally associated with its nuclear signaling function, as all antecedent proteolytic steps prior to release of Fe65 from the membrane are fostered by the APP-Fe65 interaction PMID: 17855370
    35. APP-regulated FE65 plays an important role in the early stress response of cells and that FE65 deregulated from APP induces apoptosis. PMID: 18468999
    36. Thyroid cancers are characterized by APP upregulation, increased membrane targeting of the APP ectodomain and significantly increased mRNA levels of the APP scaffold proteins JIP1, ShcA and Fe65. PMID: 18480379
    37. crystallographic analysis of the human Fe65-phosphotyrosine domain PMID: 18550529
    38. Single nucleotide polymorphisms in APBB1 gene is associated with nicotine dependence. PMID: 18777128
    39. the beta-sheet edge in some natively folded amyloid oligomers is designed positively to prevent beta aggregation PMID: 18800165
    40. Study determined the crystal structure of the carboxy-terminal APP intracellular domain in complex with the C-terminal phosphotyrosine-binding (PTB) domain of Fe65; The unique interface involves the NPxY PTB-binding motif and two alpha helices. PMID: 18833287
    41. Dexras1 functions as a suppressor of FE65-APP-mediated transcription, and FE65 tyrosine 547 phosphorylation enhances FE65-APP-mediated transcription, at least in part, by modulating the interaction between FE65 and Dexras1 PMID: 18922798
    42. The protein-protein interaction between the WW domain of Fe65 and the putative binding motif of Nedd4-2 down-regulates Fe65 protein stability and subcellular localization through its ubiquitylation, to contribute to cell apoptosis. PMID: 19381069

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane. Cytoplasm. Nucleus. Cell projection, growth cone. Nucleus speckle.
  • 組織特異性:
    Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.
  • 數據庫鏈接:

    HGNC: 581

    OMIM: 602709

    KEGG: hsa:322

    STRING: 9606.ENSP00000299402

    UniGene: Hs.372840



主站蜘蛛池模板: 国产精品一区二区av麻豆| 日本高清熟妇老熟妇| 国产精品污www在线观看| 狠狠色丁香久久婷婷综合五月| 欧美激欧美啪啪片免费看| 尹人香蕉久久99天天拍欧美p7| 国产无遮挡免费真人视频在线观看| 中国熟女仑乱hd| 欧洲美女粗暴牲交免费观看| 少妇被粗大猛进进出出s小说| 大肉大捧一进一出好爽app| 2020最新无码福利视频| 午夜香蕉成视频人网站| 超薄肉色丝袜一区二区| 亚洲色婷婷久久精品av蜜桃久久 | 欧洲熟妇色xxxxx视频| 中文字幕在线不卡精品视频99 | 亚洲欲色欲色xxxxx在线观看| 成人av一本不卡二卡| 亚洲大尺度无码专区尤物| 动漫精品啪啪一区二区三区| 国产精品一区二区av麻豆| 久久久久四虎精品免费入口| 精品国产高清毛片a片看| 久久久亚洲一区二区三区| 久久精品黄aa片一区二区三区 | 欧美 亚洲 国产 制服 中文| 高清国产在线拍揄自揄视频| 国产精品福利自产拍久久| 99精品久久99久久久久| 午夜男女无遮挡拍拍视频| 成人av片在线观看免费| 人人妻人人澡人人爽精品日本| 国产成人久久精品一区二区三区| 国产精品丝袜肉丝出水| 国产极品久久久久久久久| 青青草无码精品伊人久久| 丝袜无码一区二区三区| 国产精品人妻一区夜夜爱| 特级a做爰全过程片| 国产区在线观看成人精品|