在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ANAPC1 Antibody

  • 中文名稱:
    ANAPC1兔多克隆抗體
  • 貨號:
    CSB-PA000898
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of various cells using APC1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    ANAPC 1 antibody; Anapc1 antibody; Anaphase promoting complex subunit 1 antibody; anaphase-promoting complex 1 (meiotic checkpoint regulator) antibody; Anaphase-promoting complex subunit 1 antibody; Apc 1 antibody; APC1 antibody; APC1_HUMAN antibody; Cyclosome subunit 1 antibody; MCPR antibody; Meiotic checkpoint regulator antibody; Mitotic checkpoint regulator antibody; Protein Tsg 24 antibody; Protein Tsg24 antibody; Testis-specific gene 24 protein antibody; TSG 24 antibody; TSG24 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human APC1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
  • 基因功能參考文獻:
    1. Data show that FZR1 (Fzr), a cofactor of the multi-subunit E3 ligase complex anaphase-promoting complex/cyclosome (APC/C), represents a therapeutic target in myeloma. PMID: 27655696
    2. in the Alzheimer's disease (AD)mouse model APP/PS1, lower cdh1 levels were observed in pyramidal neurons in CA1 when compared to age-matched wildtype mice. In this review, we provide a complete list of APC/C substrates that are involved in the nervous system and we discuss their functions. We also summarize recent studies that show neurobiological effects in cdh1 knockout mouse models. PMID: 28505105
    3. cryo-EM structure of an APC/C-Cdh1 complex with Apc1(WD40) deleted showed that the mutant APC/C is locked into an inactive conformation in which the UbcH10-binding site of the catalytic module is inaccessible. Additionally, an EM density for Apc15 is not visible PMID: 27601667
    4. The ABBA-KEN-ABBA amino acid motif cassette holds the Mitotic Checkpoint Complex (MCC) onto the Anaphase-Promoting Complex-Cyclosome (APC/C) by binding the two Cdc20 molecules in the MCC-APC/C complex. PMID: 27939943
    5. findings suggest a tumor suppressor role for APC/C(Cdh1) in melanocytes and that targeting PAX3 may be a strategy for treating melanoma. PMID: 26329581
    6. Human Cytomegalovirus UL21a but not UL97 can disrupt APC/C function, leading to the accumulation of substrates and that UL21a is necessary and sufficient to induce the degradation of APC1, in addition to the previously reported APC4 and APC5. PMID: 25903336
    7. Data indicate that regulation of Rad17 turnover is through the Cdh1/anaphase-promoting complex pathway in breast cancer cells. PMID: 23637229
    8. EYA1 is efficiently degraded during mitotic exit in a ANAPC1-dependent manner and these two proteins physically interact. PMID: 23263983
    9. Single nucleotide polymorhpisms of ANAPC1 were associated with nicotine dependence. PMID: 22377092
    10. Studies indicate that the APC/C is tightly regulated by its co-activators and by the spindle assembly checkpoint. PMID: 21633387
    11. the ability of Emi1 to inhibit APC/C is negatively regulated by CDKs PMID: 21454540
    12. Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP. PMID: 21402913
    13. Studies indicate that APC/C(Cdh1) is required to maintain genomic stability. PMID: 19826416
    14. Cdh1 may function as a component in tumor suppression via proteolysis of Skp2 in colorectal tumorigenesis and may serve as a prognostic marker in colon cancer patients. PMID: 18535175
    15. ANAPC1 methylation was probably not implicated in gastric carcinogenesis PMID: 18622497

    顯示更多

    收起更多

  • 蛋白家族:
    APC1 family
  • 數據庫鏈接:

    HGNC: 19988

    OMIM: 608473

    KEGG: hsa:64682

    STRING: 9606.ENSP00000339109

    UniGene: Hs.436527



主站蜘蛛池模板: 国产69囗曝吞精在线视频| 精品国产a∨无码一区二区三区| 好吊妞无缓冲视频观看| 狠人干练合综合网| 欧美黑人巨大xxxxx视频| 综合亚洲伊人午夜网| 亚洲精品久久久久久中文字幕 | 最新777第四色米奇影视| 国产99在线 | 中国| 无卡无码无免费毛片| 欧洲熟妇牲交| 永久免费男同av无码入口| 又粗又黄又爽视频免费看 | 青草青草久热国产精品| 亚洲大片av毛片免费| 国产精品亚洲综合一区二区三区| 亚洲综合av永久无码精品一区二区| 狠狠色成人综合网| 国产av无码专区亚洲aⅴ| 中文字幕日韩人妻在线视频| 亚洲一区 日韩精品 中文字幕| 亚洲综合久久精品无码色欲| 精品无码乱码av| 中日韩精品视频在线观看| 国产成人a亚洲精v品无码| 特黄特级毛片免费视频| 真实国产精品vr专区| 亚洲欧洲成人a∨在线| 欧美老熟妇乱子伦视频| 国产乱子经典视频在线观看| 亚洲欧洲国产综合aⅴ无码| 国产一起色一起爱| 国产肥白大熟妇bbbb| 欧美日韩不卡高清在线看| 动漫精品中文无码卡通动漫| 日韩精品久久无码人妻中文字幕| 国产黑色丝袜在线观看下| 色又黄又爽18禁免费网站| 午夜理论片yy6080私人影院| 99riav国产精品视频| 欧美日韩一本无线码专区|