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ALX3 Antibody

  • 中文名稱:
    ALX3兔多克隆抗體
  • 貨號:
    CSB-PA001646LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of HepG2 cells with CSB-PA001646LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALX3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ALX3
  • 別名:
    ALX3Homeobox protein aristaless-like 3 antibody; Proline-rich transcription factor ALX3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Homeobox protein aristaless-like 3 protein (11-127AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ALX3 Antibody (CSB-PA001646LA01HU),的標記方式是Non-conjugated。對于ALX3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA001646LB01HU ALX3 Antibody, HRP conjugated ELISA
    FITC CSB-PA001646LC01HU ALX3 Antibody, FITC conjugated
    Biotin CSB-PA001646LD01HU ALX3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional regulator with a possible role in patterning of mesoderm during development.
  • 基因功能參考文獻:
    1. Genome scan using 250k Nsp1 array followed by exome and Sanger sequence analysis revealed a novel homozygous nonsense variant (c.604C>T, p.Gln202*) in the ALX3 gene resulting in frontorhiny in the family. This is the first mutation in the ALX3 gene, underlying frontorhiny, in Pakistani population. PMID: 29215096
    2. Exclusion of mutations in ALX3 gene in patients with the syndrome of frontonasal dysgenesis, callosal agenesis, basal encephalocele, and eye anomalies PMID: 22496059
    3. We report a novel Y214X mutation in ALX3 in frontorhiny. PMID: 22106187
    4. The lack of a chromosome 1-derived fragment of ALX3 in restriction landmark genomic scanning and virtual genome scans of neuroblastomas is attributable to hypermethylation. PMID: 11807986
    5. Alx3 participates in the regulation of insulin gene expression in pancreatic beta-cells. PMID: 16825292
    6. ALX3 is essential for normal facial development in humans and that deficiency causes a clinically recognizable phenotype, which we term frontorhiny. PMID: 19409524
    7. Rat Alx3 undergoes restrictive or permissive interactions with nuclear proteins that determine its binding to and transactivation from TAAT target sites selected in a cell-specific manner. PMID: 15226305
    8. Chromatin immunoprecipitation assays indicated that Alx3 in mouse pancreatic islets occupies the promoter of the mouse insulin genes. PMID: 16825292

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  • 相關疾病:
    Frontonasal dysplasia 1 (FND1)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Paired homeobox family
  • 數據庫鏈接:

    HGNC: 449

    OMIM: 136760

    KEGG: hsa:257

    STRING: 9606.ENSP00000358807

    UniGene: Hs.669953



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