在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ALPK1 Antibody

  • 中文名稱:
    ALPK1兔多克隆抗體
  • 貨號:
    CSB-PA001628GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    8430410J10Rik antibody; Alpha protein kinase 1 antibody; Alpha-protein kinase 1 antibody; ALPK1 antibody; ALPK1_HUMAN antibody; Chromosome 4 kinase antibody; LAK antibody; Lymphocyte alpha kinase antibody; Lymphocyte alpha protein kinase antibody; Lymphocyte alpha-protein kinase antibody; RGD1304613 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ALPK1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity. Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria. ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling. May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A. May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A. May play a role in ciliogenesis.
  • 基因功能參考文獻:
    1. In lung and colorectal cancer tissues, the ALPK1 RNA level of the normal part was higher than that of the tumor part. these findings suggested that ALPK1 might play a vital role in cancer development. PMID: 27283888
    2. ALPK1 is a kinase that participates in the regulation of Golgi-derived TNF-alpha trafficking through myosin IIA phosphorylation in the inflammation of gout. PMID: 27169898
    3. ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human triple negative breast cancer. PMID: 27829216
    4. these results clearly show that ALPK1 is a master regulator of innate immunity against both invasive and extracellular gram-negative bacteria. PMID: 28222186
    5. findings suggest that among genes in a gout-susceptibility locus, not ALPK1 but ABCG2 could be important as a gout-susceptible gene PMID: 25326865
    6. single nucleotide polymorphisms in the alpha-protein kinase 1 (ALPK1) gene are associated with gout in Han Chinese Taiwanese. PMID: 23569188
    7. ALPK1 may be a susceptibility gene for chronic kidney disease in such individuals with diabetes mellitus. PMID: 23539754
    8. ALPK1 is a gout-susceptible gene involved in Monosodium urate monohydrate-induced inflammatory responses and may contribute to the development of gout by enhancing the inflammatory responses via the MAP kinase pathway PMID: 21822924
    9. Transposon-inserted Alpk1 homozygous mutant mice display severe defects in motor coordination in a series of behavioral analyses. PMID: 21208416
    10. the phosphorylation of myosin I by ALPK1 is an essential process in the apical trafficking of raft-associated sucrose-isomaltase PMID: 15883161

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
  • 蛋白家族:
    Protein kinase superfamily, Alpha-type protein kinase family, ALPK subfamily
  • 組織特異性:
    Highly expressed in liver. Expressed in the optic nerve and retinal pigmented epithelium. Lower expression is observed in the macula and extramacular retina.
  • 數據庫鏈接:

    HGNC: 20917

    OMIM: 607347

    KEGG: hsa:80216

    STRING: 9606.ENSP00000177648

    UniGene: Hs.652825



主站蜘蛛池模板: 久久久久无码中| 久久婷婷丁香七月色综合| 69天堂人成无码免费视频| 最新69国产成人精品视频| 少妇无码精油按摩专区| 图片区小说区av区| 男女后进式猛烈xx00动态图片| 无码av高潮抽搐流白浆| 日韩精品中文字幕无码一区| 婷婷五月日韩av永久免费| 国产好吊看视频在线观看| 亚洲图片小说激情综合| 日日鲁鲁鲁夜夜爽爽狠狠视频97| 精品乱码一区内射人妻无码| 波多野结衣网站| 国产成人无码午夜福利在线直播 | 欧美激情一区二区三区| 午夜av亚洲一码二中文字幕青青| 亚洲欧美成人中文日韩电影网站 | 少妇与大狼拘作爱性a| 中文人妻无码一区二区三区| 亚洲狠狠色丁香婷婷综合| 国产亚洲精品久久久久久禁果tv | 东京无码熟妇人妻av在线网址| 国内精品伊人久久久久7777| 欧美日韩无套内射另类| 亚洲精品久久国产精品| 永久免费无码网站在线观看| 荡女精品导航| 色综合 图片区 小说区| 最新精品国偷自产在线老年人| 四虎av永久在线精品免费观看| 欧美老妇大p毛茸茸| 欧美z0zo人禽交欧美人禽交 | 琪琪女色窝窝777777| 被c到高潮疯狂喷水国产| 国产欧美亚洲日韩图片| 无码少妇一区二区| 色欲综合久久躁天天躁蜜桃| 久久国产人妻一区二区| 国产在线精品一区二区三区不卡|