在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ALOXE3 Antibody

ALOXE3 Antibody

  • 中文名稱：
    ALOXE3兔多克隆抗體
  • 貨號：
    CSB-PA863156ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA863156ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA863156ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ALOXE3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ALOXE3
  • 別名：
    ALOXE3 antibody; Arachidonate lipoxygenase 3 antibody; e LOX 3 antibody; E LOX antibody; e-LOX-3 antibody; eLOX3 antibody; Epidermal lipoxygenase antibody; Epidermis-type lipoxygenase 3 antibody; Lipoxygenase 3 antibody; LOXE3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Hydroperoxide isomerase ALOXE3 protein (1-280AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Non-heme iron-containing lipoxygenase which is atypical in that it displays a prominent hydroperoxide isomerase activity and a reduced lipoxygenases activity. The hydroperoxide isomerase activity catalyzes the isomerization of hydroperoxides, derived from arachidonic and linoleic acid by ALOX12B, into hepoxilin-type epoxyalcohols and ketones. In presence of oxygen, oxygenates polyunsaturated fatty acids, including arachidonic acid, to produce fatty acid hydroperoxides. In the skin, acts downstream of ALOX12B on the linoleate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. In parallel, it may have a signaling function in barrier formation through the production of hepoxilins metabolites. Plays also a role in adipocyte differentiation through hepoxilin A3 and hepoxilin B3 production which in turn activate PPARG. Through the production of hepoxilins in the spinal cord, it may regulate inflammatory tactile allodynia.
  • 基因功能參考文獻：
    1. Case Report: ALOXE3 mutation causing congenital ichthyosis and recurrent eczema. PMID: 27868147
    2. In summary, we have identified three novel sequence variants, one in TGM1 and two in ALOXE3, in three consanguineous families segregating lamellar ichthyosis and congenital ichthyosiform erythroderma types of autosomal recessive congenital ichthyosis. PMID: 26578203
    3. Case Report: homozygous ALOXE3 mutation causing autosomal recessive congenital ichthyosis. PMID: 25423909
    4. Loss-of-function mutations in the LOX genes ALOX12B and ALOXE3 have been found to represent the second most common cause of autosomal recessive congenital ichthyosis. [review] PMID: 23954555
    5. This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3. [review] PMID: 24021977
    6. Autosomal recessive congenital ichthyosis patients with NIPAL4 mutations and abnormal ichthyin expression showed increased 12R-LOX and eLOX-3 staining and a colocalization signal of these LOXs that was three times the normal intensity. PMID: 22622417
    7. On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1. PMID: 20923767
    8. Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. PMID: 20921226
    9. ALOX12B mutations are the leading cause of self-improving collodion ichthyosis in Scandinavia, followed by ALOXE3 mutations, and TGM1 mutations PMID: 19890349
    10. Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. PMID: 11773004
    11. eLOX-3 hydrolase functions in the normal process of skin differentiation, and that the loss of function mutations are the basis of the LOX-dependent form of Non-bullous congenital ichthyosiform erythroderma. PMID: 15629692
    12. The substrate preference of mouse eLOX3 and the unique occurrence of an 8S-LOX enzyme in mouse skin point to a potential LOX pathway for the production of epoxyalcohol in murine epidermal differentiation. PMID: 17045234
    13. Formation of a ligand for the nuclear receptor PPARalpha may be one possibility by which 12R-LOX and eLOX3 contribute to epidermal differentiation. PMID: 17436029
    14. mutation hotspots in ALOXE3 and allelic heterogeneity in ALOX12B may have roles in autosomal recessive congenital ichthyosis PMID: 19131948

    顯示更多

    收起更多

  • 相關疾病：
    Ichthyosis, congenital, autosomal recessive 3 (ARCI3)
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Lipoxygenase family
  • 組織特異性：
    Predominantly expressed in skin.
  • 數據庫鏈接：

    HGNC: 13743

    OMIM: 606545

    KEGG: hsa:59344

    STRING: 9606.ENSP00000314879

    UniGene: Hs.232770



主站蜘蛛池模板： 一道久在线无码加勒比| 日本在线a一区视频| 五月婷婷久久草| 99久久99久久精品免费观看| 日本一本二本三区免费| 无码区日韩特区永久免费系列| 亚洲欧美人成网站在线观看看 | 无码人妻av一区二区三区波多野| 丰满女人又爽又紧又丰满| 疯狂做受xxxx高潮不断| a狠狠久久蜜臀婷色中文网| 欧美亚洲日韩不卡在线在线观看| 国产精品久久久久久久久ktv| 无码日本精品xxxxxxxxx| 欧美性性性性o00xx| 国产一卡二卡三卡四卡视频版| 亚洲老妇色熟女老太| 国产精品爱啪在线播放| 无码日韩人妻av一区免费| 五月天中文字幕mv在线| 国产va在线观看免费| 亚洲欧洲日产韩国无码| 国产剧情无码播放在线观看| 无码av一区二区三区无码 | 久久久国产乱子伦精品| 亚洲乱码国产一区三区| 国内精品视这里只有精品| 国产成人欧美日韩在线电影 | 玖玖资源站无码专区| 婷婷丁香五月中文字幕| 大陆精大陆国产国语精品 | 亚洲一区av无码少妇电影| 国产精品高潮呻吟av久久小说| 免费天堂无码人妻成人av电影| 亚洲成av人片香蕉片| 日本孕妇潮喷高潮视频| 四虎www永久在线精品| 国产精品 视频一区 二区三区 | 99精品热这里只有精品| 女人被爽到高潮视频免费国产| 激情综合色综合啪啪五月丁香|