在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ALKBH3 Antibody

  • 中文名稱:
    ALKBH3兔多克隆抗體
  • 貨號:
    CSB-PA847209HA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry analysis of human testis tissue using CSB-PA847209HA01HU at dilution of 1:100
    • Immunocytochemistry analysis of human skeletal muscle tissue using CSB-PA847209HA01HU at dilution of 1:100
    • Immunofluorescent analysis of PC-3 cells using CSB-PA847209HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ALKBH3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ALKBH3
  • 別名:
    1700108H04Rik antibody; 1810020C19Rik antibody; ABH3 antibody; AlkB homolog 3 antibody; alkB; alkylation repair homolog 3 (E. coli) antibody; ALKB3_HUMAN antibody; ALKBH3 antibody; Alkylated DNA repair protein alkB homolog 3 antibody; alkylation repair homolog 3 antibody; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 antibody; DEPC 1 antibody; DEPC-1 antibody; DEPC1 antibody; EC 1.14.11. antibody; FLJ43614 antibody; mABH3 antibody; MGC118790 antibody; MGC118792 antibody; MGC118793 antibody; MGC134125 antibody; PCA1 antibody; Prostate cancer antigen 1 antibody; Prostate cancer antigen-1 antibody; RP23-375N21.4 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 protein (1-170AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,ALKBH3 Antibody (CSB-PA847209HA01HU),的標記方式是Non-conjugated。對于ALKBH3 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA847209HB01HU ALKBH3 Antibody, HRP conjugated ELISA
    FITC CSB-PA847209HC01HU ALKBH3 Antibody, FITC conjugated
    Biotin CSB-PA847209HD01HU ALKBH3 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron.
  • 基因功能參考文獻:
    1. These data highlight a novel role for ALKBH3 in tumor progression via RNA demethylation and subsequent protein synthesis promotion. PMID: 28205560
    2. ALKBH3 is a novel addition to the catalogue of DNA repair genes found inactivated in breast cancer. Our results underscore a link between defective alkylation repair and breast cancer which, additionally, is found in association with poor disease outcome. PMID: 28679371
    3. The TP53 knockout shifted the phenotypes of A549 cells induced by ALKBH3 knockdown from cell cycle arrest to apoptosis induction, suggesting that the TP53 gene status is a critical determinant of the phenotypes induced by ALKBH3 knockdown in NSCLC cells. PMID: 28479246
    4. These results revealed that N3-ethylthymidine , but not other DNA lesions, could be repaired by Alkbh2 and Alkbh3 in mammalian cells. PMID: 26930515
    5. Results show that PCA1 expression was positively correlated with advanced stages in renal cell carcinoma and strongly suggest that PCA-1 may be functionally important and a novel molecular target for human renal cell carcinoma. PMID: 26035443
    6. It was shown for first time that DNA glycosylase ALKBH3 can repair DNA adduct 3,N4-ethenocytosine from single-stranded DNA. PMID: 25797601
    7. ALKBH3 contributes to development of urothelial carcinomas by accelerating their survival, angiogenesis, and invasion PMID: 22850567
    8. ALKBH3 gene silencing markedly induces apoptosis in hormone-independent prostate cancer cell line DU145. PMID: 22515525
    9. Our results establish PCA-1/ALKBH3 as important gene in pancreatic cancer PMID: 22826605
    10. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. PMID: 22055184
    11. ALKBH3 contributes significantly to cancer cell survival and may be a therapeutic target for human adenocarcinoma of the lung. PMID: 21285982
    12. This work has provided a detailed understanding of the structural features of the single-stranded DNA and double-stranded DNA preferences of ABH2 and ABH3. PMID: 20714506
    13. Divergent sequences outside of the active site determine substrate specificities of ABH3. PMID: 20525795
    14. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) PMID: 20970119
    15. Crystallographic study reveals beta-strand jelly-roll fold of hABH3 that coordinates a catalytically active iron center by a conserved His1-X-Asp/Glu-X(n)-His2 motif [ABH3] PMID: 16858410
    16. PCA-1 might be a novel diagnostic marker for prostate cancer, and increased PCA-1 expression might denote more aggressive variants of prostate cancer [PCA-1]. PMID: 17968469

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    AlkB family
  • 組織特異性:
    Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon.
  • 數據庫鏈接:

    HGNC: 30141

    OMIM: 610603

    KEGG: hsa:221120

    STRING: 9606.ENSP00000302232

    UniGene: Hs.720708



主站蜘蛛池模板: 成熟老妇女毛茸茸的做性| 日韩人妻无码中文字幕视频| 18禁午夜宅男成年网站| 亚洲人成网线在线播放va蜜芽| 国产乱人偷精品人妻a片| 男人下部进女人下部视频| 97国产精品麻豆性色aⅴ人妻波| 欧美gv在线观看| 无码熟熟妇丰满人妻啪啪| 国产做爰xxxⅹ久久久小说| 国产亚洲日本精品无码| 蜜桃mv在线播放免费观看视频| 中文字字幕人妻中文| 国产午夜成人av在线播放| 人妻久久久精品99系列2021| 亚洲国产精品无码久久一区二区| 麻豆成人av不卡一二三区| 99久久精品免费看国产| 99久久精品无码一区二区三区| 亚洲处破女av日韩精品| 精品国产一区二区三区久久狼 | 欧美色欧美亚洲另类二区| 亚洲国产精品一区二区动图| 日本大片免费观看视频| 性欧美老妇另类xxxx| 国产成人无码www免费视频播放| 久久99精品久久久久久齐齐| 国产亚洲精品久久久久久无| 丝袜美腿亚洲一区二区| 精品久久久久久久久久久aⅴ| 欧美熟妇性开放| 午夜理论片在线观看免费| 日韩免费无码专区精品观看| 国产suv精品一区二区四| 99国产精品久久久蜜芽| 3d成人h动漫网站入口| 在线播放午夜理论片| 美女裸体无遮挡免费视频网站| 精品国际久久久久999| 欧美综合乱图图区乱图图区| 嫩草国产露脸精品国产软件|