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  4. ALKBH1 Antibody

ALKBH1 Antibody

  • 中文名稱：
    ALKBH1兔多克隆抗體
  • 貨號：
    CSB-PA614439ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA614439ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ALKBH1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ALKBH1
  • 別名：
    ABH antibody; ABH1 antibody; alkB antibody; alkB homolog 1 histone H2A dioxygenase antibody; AlkB; alkylation repair homolog 1 (E. coli) antibody; ALKB1_HUMAN antibody; ALKBH antibody; ALKBH1 antibody; Alkylated DNA repair protein alkB homolog 1 antibody; Alkylation repair homolog 1 antibody; Alkylation repair; alkB homolog antibody; Alpha-ketoglutarate-dependent dioxygenase ABH1 antibody; DNA lyase ABH1 antibody; DNA oxidative demethylase ALKBH1 antibody; hABH antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Alkylated DNA repair protein alkB homolog 1 protein (110-389AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Dioxygenase that acts as on nucleic acids, such as DNA and tRNA. Requires molecular oxygen, alpha-ketoglutarate and iron. A number of activities have been described for this dioxygenase, but recent results suggest that it mainly acts as on tRNAs and mediates their demethylation or oxidation depending on the context and subcellular compartment. Mainly acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs, with a preference for N(1)-methyladenine at position 58 (m1A58) present on a stem loop structure of tRNAs. Acts as a regulator of translation initiation and elongation in response to glucose deprivation: regulates both translation initiation, by mediating demethylation of tRNA(Met), and translation elongation, N(1)-methyladenine-containing tRNAs being preferentially recruited to polysomes to promote translation elongation. In mitochondrion, specifically interacts with mt-tRNA(Met) and mediates oxidation of mt-tRNA(Met) methylated at cytosine(34) to form 5-formylcytosine (f(5)c) at this position. mt-tRNA(Met) containing the f(5)c modification at the wobble position enables recognition of the AUA codon in addition to the AUG codon, expanding codon recognition in mitochondrial translation. Specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA. N(6)-methyladenosine (m6A) DNA is present at some L1 elements in embryonic stem cells and probably promotes their silencing. Demethylates mRNAs containing N(3)-methylcytidine modification. Also able to repair alkylated single-stranded DNA by oxidative demethylation, but with low activity. Also has DNA lyase activity and introduces double-stranded breaks at abasic sites: cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketboglutarate and iron and leads to the formation of an irreversible covalent protein-DNA adduct with the 5' DNA product. DNA lyase activity is not required during base excision repair and class switch recombination of the immunoglobulin heavy chain during B lymphocyte activation. May play a role in placental trophoblast lineage differentiation.
  • 基因功能參考文獻：
    1. This study characterized ALKBH1 to be a mitochondrial-localized protein with N6-methyldeoxyadenosine demethylation activity. Loss of ALKBH1 also disrupted mitochondrial OXPHOS function. PMID: 30412255
    2. Localization and subcellular fractionation studies with the endogenous protein in two cell strains confirm that ALKBH1 is primarily in the mitochondria. PMID: 29097205
    3. Nuclear and mitochondrial ALKBH1 play distinct roles in tRNA modification. PMID: 28472312
    4. The authors identify ALKBH1/ABH1 as the dioxygenase responsible for oxidising m(5)C34 of mt-tRNA(M)(et) to generate an f(5)C34 modification. PMID: 27497299
    5. The authors postulate that the very low 6-methyl adenine oxygenase activity associated with ALKBH1 is unlikely to represent the major function of the enzyme in the cell, while the cellular role of the lyase activity (including its subsequent covalent attachment to DNA) remains uncertain. PMID: 28290676
    6. The ALKBH1-catalyzed demethylation of the target tRNAs results in attenuated translation initiation and decreased usage of tRNAs in protein synthesis. PMID: 27745969
    7. AlkB has a wide variety of substrates, including monoalkyl and exocyclic bridged adducts. (Review) PMID: 26152727
    8. ALKBH1's role in class switch recombination and abasic site cleavage during base excision repair PMID: 23825659
    9. Primary and secondary lysine residues of ALKBH1 are involved in lyase reactions and form a covalent adduct with the 5'DNA product, demonstrating two plausible chemical mechanisms to account for the covalent attachment. PMID: 23577621
    10. Homology modeling and different tertiary structure based study were performed on human AlkB homolog hABH1. PMID: 21956739
    11. show that ABH1 unexpectedly has a second activity, cleaving DNA at abasic (AP) sites such as those arising spontaneously from alkylation-dependent depurination reactions. PMID: 19959401
    12. AlkB homologues, hABH2 and hABH3, also are oxidative DNA demethylases; AlkB and hABH3, but not hABH2, also repair RNA PMID: 12594517
    13. hABH1 is a functional mitochondrial AlkB homolog that repairs 3-methylcytosine in single-stranded DNA and RNA. PMID: 18603530

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  • 亞細胞定位：
    Nucleus. Mitochondrion.
  • 蛋白家族：
    AlkB family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 17911

    OMIM: 605345

    KEGG: hsa:8846

    STRING: 9606.ENSP00000216489

    UniGene: Hs.94542



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