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ALDH1B1 Antibody

  • 中文名稱:
    ALDH1B1兔多克隆抗體
  • 貨號:
    CSB-PA942262
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human liver cancer tissue, Primary antibody: CSB-PA942262(ALDH1B1 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 50 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ALDH1B1
  • 別名:
    Acetaldehyde dehydrogenase 5 antibody; AL1B1_HUMAN antibody; Aldehyde dehydrogenase 1 family; member B1 antibody; Aldehyde dehydrogenase 1B1 antibody; Aldehyde dehydrogenase 5 antibody; Aldehyde dehydrogenase family 1 member B1 antibody; Aldehyde dehydrogenase X antibody; Aldehyde dehydrogenase X mitochondrial antibody; ALDH class 2 antibody; Aldh1b1 antibody; ALDH5 antibody; ALDHX antibody; MGC2230 antibody; Mitochondrial aldehyde dehydrogenase X antibody; mitochondrial antibody; OTTHUMP00000021399 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human ALDH1B1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
  • 基因功能參考文獻:
    1. These results suggest that ALDH1B1 is a novel human colorectal cancer biomarker PMID: 28881356
    2. The aims of this study were: (i) to use bioinformatic techniques to characterize the possible effects of selected variants in ALDH1B1 on protein structure and function; and, (ii) to genotype three missense and one stop-gain, protein-altering, non-synonymous single nucleotide polymorphisms in 1478 alcohol dependent cases and 1254 controls of matched British and Irish ancestry. PMID: 28594837
    3. ALDH1B1 is expressed at very high levels in human pancreatic cancer, and it contributes to proliferation in these tumor cells. PMID: 26566217
    4. High expression of ALDH1A2 and ALDH1B1 mRNA was found to be significantly correlated to worser survival in all NSCLC patients. PMID: 26366059
    5. Data show that ALDH1B1 may promote colon cancer tumorigenesis by modulating the Wnt/beta-catenin, Notch and PI3K/Akt signaling pathways. PMID: 25950950
    6. ALDH1B1 metabolizes nitroglycerin and all-trans-retinaldehyde. One of the three human polymorphisms, ALDH1B1*2, is catalytically inactive, likely due to poor NAD(+) binding. PMID: 25413692
    7. ALDH1B1 SNPs play a role in shaping the alcohol drinking patterns among the Inuit in Greenland. PMID: 25311581
    8. ALDH1 is indicative of stemness and is a biomarker marker in colon cancer. PMID: 24953984
    9. ALDH1B1 is more profoundly expressed in the adenocarcinomas examined in this study relative to ALDH1A1 and that ALDH1B1 is dramatically upregulated in human colonic adenocarcinoma, making it a potential biomarker for human colon cancer. PMID: 21216231
    10. An ALDHX model based on the crystal structure of human ALDH2, reveals similarities with the previously described ALDH structures. Analyses indicate a close structural and functional relationship between the two isoenzymes of human origin PMID: 20955166
    11. a common SNP encoding ALDH1b1 (rs2228093) was found to be significantly associated with alcohol-induced hypersensitivity. PMID: 20205700
    12. ALDH1b1 ala69val was associated with diastolic blood pressure in a Caucasian population sample PMID: 18782342

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  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Aldehyde dehydrogenase family
  • 組織特異性:
    Liver, testis and to a lesser extent in brain.
  • 數據庫鏈接:

    HGNC: 407

    OMIM: 100670

    KEGG: hsa:219

    STRING: 9606.ENSP00000366927

    UniGene: Hs.436219



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