在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AKR1C4 Antibody

  • 中文名稱:
    AKR1C4兔多克隆抗體
  • 貨號:
    CSB-PA001545GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    AKR1C4
  • 別名:
    3 alpha HSD1 antibody; 3-alpha-HSD1 antibody; 3-alpha-hydroxysteroid dehydrogenase type I antibody; AK1C4_HUMAN antibody; AKR1C4 antibody; Aldo keto reductase family 1 member C4 antibody; Aldo-keto reductase family 1 member C4 antibody; CDR antibody; Chlordecone reductase antibody; DD-4 antibody; DD4 antibody; Dihydrodiol dehydrogenase 4 antibody; HAKRA antibody; HSD3a antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human AKR1C4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Liver specific enzyme that acts as NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH. Acts preferentially as a 3-alpha-hydroxysteroid dehydrogenase (HSD) with a subsidiary 3-beta-HSD activity. Catalyzes efficiently the transformation of the potent androgen 5-alpha-dihydrotestosterone (5alpha-DHT or 17beta-hydroxy-5alpha-androstan-3-one) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Catalyzes the reduction of estrone into 17beta-estradiol but with low efficiency. Metabolizes a broad spectrum of natural and synthetic therapeutic steroid and plays an important role in metabolism of androgens, estrogens, progestereone and conjugated steroids. Catalyzes the biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leading to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
  • 基因功能參考文獻:
    1. the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells. PMID: 28259989
    2. Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency. PMID: 24189185
    3. In women only, SNPs in AKR1C4 reduced the likelihood of having exhibited paranoid ideation by circa 60%. PMID: 22356824
    4. Low progesterone levels and a cystine to serine change at position 145 in AKR1C4 gene are associated with manic/hypomanic irritability in males PMID: 21570127
    5. role of AKR1C4 in the metabolism of testosterone and progesterone via the 5beta-reductase pathway. PMID: 21521174
    6. Taken together, we conclude that the cell-type-specific expression of DD4 mRNA is regulated by vHNF-1-C. PMID: 12220531
    7. the expression level of DD4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma. PMID: 12544512
    8. Impact of mirtazapine on the activity of a key neurosteroidogenic enzyme, the 3alpha-hydroxysteroid dehydrogenase (3alpha-HSD), and on the levels of neuroactive steroids in relation to clinical response in depression. PMID: 16344854
    9. Structure determination of human AKR1C4 and homology modelling of AKR1D1 followed by docking experiments were used to explore active site geometries. PMID: 19013211

    顯示更多

    收起更多

  • 相關疾病:
    46,XY sex reversal 8 (SRXY8)
  • 亞細胞定位:
    Cytoplasm, cytosol.
  • 蛋白家族:
    Aldo/keto reductase family
  • 組織特異性:
    Liver specific.
  • 數據庫鏈接:

    HGNC: 387

    OMIM: 600451

    KEGG: hsa:1109

    STRING: 9606.ENSP00000263126

    UniGene: Hs.567245



主站蜘蛛池模板: 先锋影音最新色资源站| 亚洲国产成人久久综合碰 | 美女露全乳无遮掩视频| 性色欲情网站iwww| 国产美女视频免费观看的网站| 无码免费无线观看在线视| 亚洲精品久久国产高清小说 | 潮喷失禁大喷水无码| 亚洲中文字幕日产无码成人片| 吃奶摸下高潮60分钟免费视频 | 国产亚洲精品久久久久久国| 成人夜色视频网站在线观看| 成人国产精品一区二区免费看| 性色av免费网站| 亚洲精品久久久久久一区二区| 国产精品videossex久久发布 | 巨胸喷奶水视频www免费网站| 人妻少妇无码精品专区| 99久re热视频这里只有精品6| 精品蜜臀久久久久99网站| 鲁丝一区二区三区免费| 亚洲无人区码一码二码三码的含义| 午夜婷婷精品午夜无码a片影院| 欧美丰满大爆乳波霸奶水多| 人妻精品久久久久中文字幕69| 精品国精品国产自在久国产应用| 色欲一区二区三区精品a片| 国产精品久久综合免费| 久久www成人免费直播| 国产日韩欧美一区二区东京热| 综合无码一区二区三区| 国产精品一区二区av麻豆| 中文成人无码精品久久久动漫| 人妻少妇久久中文字幕| 婷婷四房播播| 国内精品久久久久久久影视| 啪啪激情婷婷久久婷婷色五月 | 中文无码久久精品| 国产男女无遮挡猛进猛出| 亚洲成国产人片在线观看| 国产人妻精品一区二区三首|