在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

AKAP8L Antibody

  • 中文名稱:
    AKAP8L兔多克隆抗體
  • 貨號:
    CSB-PA892152ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA892152ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA892152ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) AKAP8L Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    AKAP8L antibody; NAKAP antibody; NAKAP95 antibody; HRIHFB2018A-kinase anchor protein 8-like antibody; AKAP8-like protein antibody; Helicase A-binding protein 95 antibody; HAP95 antibody; Homologous to AKAP95 protein antibody; HA95 antibody; Neighbor of A-kinase-anchoring protein 95 antibody; Neighbor of AKAP95 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human A-kinase anchor protein 8-like protein (1-240AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export. Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA. May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis. May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta. Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8. May be involved in regulation of pre-mRNA splicing.; (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.; (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.; (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.
  • 基因功能參考文獻:
    1. Results indicate that in vitro, the interaction between HA95 and LAP2beta is influenced by a PKA-mediated phosphorylation of HA95 rather than by CDK1- or PKC-mediated phosphorylation of LAP2beta PMID: 12950172
    2. NAKAP-HypA scaffold is a potential nuclear docking site for huntingtin protein and may contribute to the nuclear accumulation of huntingtin observed in HD PMID: 16391387
    3. Nuclear PKA C subunit co-locates with HA95 in splicing factor compartments and regulates pre-mRNA splicing, possibly through a cAMP-independent mechanism. PMID: 17594903
    4. These results infer that RNF43 is a resident protein of the ER and, at least partially, the nuclear membrane, with ubiquitin ligase activity and may be involved in cell growth control potentially through the interaction with HAP95. PMID: 18313049
  • 亞細胞定位:
    Nucleus. Nucleus matrix. Nucleus speckle. Nucleus, PML body. Cytoplasm.
  • 蛋白家族:
    AKAP95 family
  • 組織特異性:
    Ubiquitously expressed. Expressed in the brain cortex (at protein level).
  • 數據庫鏈接:

    HGNC: 29857

    OMIM: 609475

    KEGG: hsa:26993

    STRING: 9606.ENSP00000380557

    UniGene: Hs.399800



主站蜘蛛池模板: 亚洲欧美日韩中文加勒比| 国产一区二区内射最近更新| 欧美最猛黑人xxxx| 国产精品久久国产精品99 gif| 亚洲一区激情校园小说| 伊人蕉影院久亚洲高清| 夜夜躁狠狠躁日日躁2022| 国产精品厕所| 曰曰摸夜夜添夜夜添高潮出水| 另类老妇奶性生bbwbbw| 亚洲成h人av无码动漫无遮挡| 一本天堂v无码亚洲道久久| 人妻aⅴ中文字幕无码| 中国少妇内射xxxhd免费| ass日本丰满熟妇pics| 久久精品国产99国产精偷| 99久久精品国产成人综合| 亚洲成av人片在www鸭子| 无码专区久久综合久中文字幕| 人妻内射一区二区在线视频 | 国产成人一区二区不卡免费视频| 国产亚洲欧美在线专区| 美女张开腿让男人桶爽| 亚洲伊人成综合人影院青青青| 久久激情五月丁香伊人| 人妻少妇精品中文字幕av蜜桃| 色情久久久av熟女人妻网站| 亚洲成在人线a免费77777| 国产免码va在线观看免费 | 鲁死你av资源站| 精品人妻一区二区三区浪潮在线| 国产午夜大地久久| 一本大道久久香蕉成人网| 少妇无码av无码专线区大牛影院 | 碰超免费人妻中文字幕| 亚洲欧美日韩成人一区在线| 一区二区三区国产| 国产 麻豆 日韩 欧美 久久| 国产第一页浮力影院入口 | 亚洲日韩乱码中文字幕| 色欲天天婬色婬香综合网|