在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AHSA1 Antibody

AHSA1 Antibody

  • 中文名稱：
    AHSA1兔多克隆抗體
  • 貨號：
    CSB-PA000833
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using AHA-1 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    AHSA1
  • 別名：
    Activator of 90 kDa heat shock protein ATPase homolog 1 antibody; Activator of heat shock 90kDa protein ATPase homolog 1 antibody; AHA 1 antibody; AHA1 antibody; AHSA 1 antibody; Ahsa1 antibody; AHSA1_HUMAN antibody; C14orf3 antibody; HSPC322 antibody; p38 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human AHA-1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a co-chaperone of HSP90AA1. Activates the ATPase activity of HSP90AA1 leading to increase in its chaperone activity. Competes with the inhibitory co-chaperone FNIP1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins. Competes with the inhibitory co-chaperone TSC1 for binding to HSP90AA1, thereby providing a reciprocal regulatory mechanism for chaperoning of client proteins.
  • 基因功能參考文獻：
    1. Aha1 colocalized with tau pathology in brain tissue, and this association positively correlated with Alzheimer disease progression. PMID: 28827321
    2. These results suggest that differences in the middle domain of Hsp90alpha and Hsp90beta may be responsible for the isoform-specific interactions with selected proteins. PMID: 25486457
    3. Aha1 may promote disposal of folding defective proteins by the cellular protein quality control. PMID: 25378400
    4. a monoallelic mutation of p53 was sufficient to activate the Aha1/Hsp90 ATPase axis leading to stimulation of Wnt signaling and increased expression of Wnt target genes. PMID: 24451373
    5. Modulation of Hsp90 activity by AHA1 regulates VEGF signaling to eNOS and angiogenesis. PMID: 22859491
    6. The interaction of Aha1 with Hsp90 and its co-chaperones in rabbit reticulocyte lysate (RRL) and in HeLa cell extracts, was characterized. PMID: 22504172
    7. Hsp90 phosphorylation on tyrosine313 promotes recruitment of AHA1, which stimulates Hsp90 ATPase activity, furthering the chaperoning process. PMID: 22727666
    8. Data propose a model for Aha1 in the Hsp90 ATPase cycle where Aha1 regulates dwell time of Hsp90, and suggest Aha1 activity integrates chaperone function with client folding energetics by modulating ATPase sensitive dimer structural transitions. PMID: 20089831
    9. stimulates the inherent ATPase activity of Hsp90 PMID: 12504007
    10. Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum PMID: 17110338

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Endoplasmic reticulum. Note=May transiently interact with the endoplasmic reticulum.
  • 蛋白家族：
    AHA1 family
  • 組織特異性：
    Expressed in numerous tissues, including brain, heart, skeletal muscle and kidney and, at lower levels, liver and placenta.
  • 數據庫鏈接：

    HGNC: 1189

    OMIM: 608466

    KEGG: hsa:10598

    STRING: 9606.ENSP00000216479

    UniGene: Hs.204041



主站蜘蛛池模板： 国产成人无码视频网站在线观看| 狠狠人妻久久久久久综合蜜桃| 国产黄大片在线观看画质优化| 欧美激情肉欲高潮视频| 国产精品无码av天天爽播放器 | 久久国产人妻一区二区| 成人欧美一区二区三区| 18禁裸乳无遮挡啪啪无码免费 | 老师黑色丝袜被躁翻了av| 白嫩少妇bbw撒尿视频| 粗大的内捧猛烈进出视频| 亚洲成av人片香蕉片| 蜜臀av午夜一区二区三区| 思思99re6国产在线播放| 狠狠噜狠狠狠狠丁香五月| 无码乱人伦一区二区亚洲| 久久99成人免费| 人人爽久久涩噜噜噜av| 天堂久久天堂av色综合| 亚洲中文字幕无码日韩精品| 韩日午夜在线资源一区二区| 熟女丰满老熟女熟妇| 大香线蕉伊人精品超碰| 丰满人妻熟妇乱又伦精品app| 亚洲狠狠婷婷综合久久久久图片| 99久久国产露脸国语对白| 国产精品三级国产电影| 国产农村乱辈无码| 在线观看国产亚洲视频免费 | 国产99久久精品一区二区| 少妇特黄a一区二区三区| 亚洲精品乱码久久久久久蜜桃不卡| 137日本免费肉体摄影| 欧美无人区码suv| 国产精品久久久久久亚洲影视内衣| 日产日韩亚洲欧美综合下载| 国产精品天堂avav在线| 久久精品国产欧美日韩| 熟女俱乐部五十路六十路av| 久久天堂av综合合色蜜桃网| 亚洲精品无码专区在线播放|