在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGRN Antibody, HRP conjugated

AGRN Antibody, HRP conjugated

  • 中文名稱：
    AGRN兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA001461LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) AGRN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AGRIN antibody; Agrin C-terminal 22 kDa fragment antibody; Agrin proteoglycan antibody; AGRIN_HUMAN antibody; Agrn antibody; C22 antibody; C90 antibody; FLJ45064 antibody; OTTHUMP00000044043 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Agrin protein (968-1130AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain.; transmembrane form that is the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.; Isoform 1, isoform 4 and isoform 5: neuron-specific (z+) isoforms that contain C-terminal insertions of 8-19 AA are potent activators of AChR clustering. Isoform 5, agrin (z+8), containing the 8-AA insert, forms a receptor complex in myotubules containing the neuronal AGRN, the muscle-specific kinase MUSK and LRP4, a member of the LDL receptor family. The splicing factors, NOVA1 and NOVA2, regulate AGRN splicing and production of the 'z' isoforms.; Isoform 3 and isoform 6: lack any 'z' insert, are muscle-specific and may be involved in endothelial cell differentiation.; is involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling.; this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.
  • 基因功能參考文獻：
    1. High Agrin expression is associated with Chronic obstructive pulmonary disease. PMID: 29351440
    2. The presence of agrin at locations with particular importance for the growth and stability of atherosclerotic plaques renders this molecule strategically positioned to influence plaque development and vulnerability PMID: 29405249
    3. C-terminal agrin fragment levels predict acute kidney injury after acute myocardial infarction. PMID: 28646861
    4. Agrin promotes oncogenesis through YAP-dependent transcription. PMID: 28273460
    5. Agrin strongly promotes chondrocyte differentiation and cartilage formation in vivo. PMID: 26290588
    6. Knockdown of agrin and perlecan promoted a decrease on cell migration and adhesion, and on resistance of cells to cisplatin. PMID: 25506919
    7. Among 42 hip fractured patients (age 83.7+/-8.6 years, 76.2% women), sarcopenia was diagnosed in 7 individuals (16.7%). Serum C-terminal agrin fragment (CAF) levels were significantly higher in sarcopenic relative to non-sarcopenic patients. PMID: 25304331
    8. In patients suffering from severe sepsis and septic shock, serum levels of C-terminal agrin fragment were significantly associated with kidney function and the need for renal replacement therapy and were not influenced by severe septic conditions. PMID: 25807640
    9. MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters PMID: 24244707
    10. these observations indicate that agrin is another autoantigen in patients with MG and agrin autoantibodies may be pathogenic through inhibition of agrin/LRP4/MuSK signaling at the NMJ. PMID: 24632822
    11. Five new recessive mutations in the gene encoding agrin are identified in patients with congenital myasthenic syndrome. PMID: 24951643
    12. study identifies a spontaneous agrin mutation that reduces the ability of z+ agrin to activate MuSK and induce AChR clustering; this results in a severe congenital myasthenic syndrome in the patient, with both pre- and postsynaptic defects at the neuromuscular junction PMID: 22205389
    13. Dynamics of expression patterns of agrin in human glioblastoma PMID: 22307776
    14. In contrast to wild-type neurons which form synapses and survive for prolonged periods, agrin-deficient neurons do not mature and are rapidly eliminated in the transgenic olfactory bulb. PMID: 22423096
    15. Agrin immunohistochemistry may facilitate determination of primary versus metastatic origin in problematic liver cancer cases. PMID: 20471664
    16. different regions within the agrin protein are responsible for synapse formation at the neuromuscular junction and for process formation in central nervous system neurons PMID: 19940118
    17. Agrin, a heparan sulfate proteoglycan, is a component of the basal lamina of BBB microvessels, and growing evidence suggests that it may be important for the maintenance of the BBB. PMID: 12070669
    18. acts at the nerve-muscle synapse in the glomerular basal membrane and on T-lymphocytes PMID: 12073527
    19. evidence for additional functions of agrin during axonal growth, establishment of the blood-brain barrier, and Alzheimer's disease is accumulating--REVIEW PMID: 12270958
    20. Thus, an agrin/MuSK complex may form part of a motor neuron stop signal involved in "reverse signaling" to the motor neuron. PMID: 15691710
    21. in the NtA-laminin complex, conserved amino acids in the gamma 1 chain are prerequisite for the binding to agrin PMID: 15694127
    22. agrin has a role in binding alpha-synuclein and modulating alpha-synuclein fibrillation PMID: 16037493
    23. In human sperm an agrin isoform with a short NH2-terminus (agrinSN) localized in the posterior post-acrosomal, neck, and flagellar mid-piece regions. PMID: 16487930
    24. agrin might play an important role in neoangiogenesis in human HCC, being a part of the newly formed vasculature. In CC, however, agrin might be involved in tumor progression PMID: 17640714
    25. The agrin expression in human T cells is regulated by cell activation and IFN-alpha, and may have an important function during cell activation with potential implications for autoimmunity. PMID: 18025246
    26. study concludes that Abeta can modulate the cellular expression of agrin and glypican-1, which may contribute to the accumulation of these heparan sulfate proteoglycans in Alzheimer's disease lesions PMID: 19166823
    27. agrin facilitates the discrimination of benign and malignant hepatocellular lesions PMID: 19194276
    28. The agrin mutation does not interfere with its ability to induce postsynaptic structures but that it dramatically perturbs the maintenance of the neuromuscular junction. PMID: 19631309
    29. Observational study of gene-disease association. (HuGE Navigator) PMID: 19598235

    顯示更多

    收起更多

  • 相關疾病：
    Myasthenic syndrome, congenital, 8 (CMS8)
  • 亞細胞定位：
    [Isoform 1]: Secreted, extracellular space, extracellular matrix.; [Isoform 2]: Cell junction, synapse. Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neur
  • 數據庫鏈接：

    HGNC: 329

    OMIM: 103320

    KEGG: hsa:375790

    STRING: 9606.ENSP00000368678

    UniGene: Hs.273330



主站蜘蛛池模板： 国产精品视频免费播放| 久久亚洲精品无码播放| 亚洲国产精彩中文乱码av| 女人爽到喷水的视频大全| 无码中字出轨中文人妻中文中| 黄床片30分钟免费视频教程| 久久国产av影片| 亚洲欧洲中文日韩久久av乱码| 人妻内射一区二区在线视频| 伊人情人色综合网站| 中文字幕精品视频在线看免费| 国产精品亚洲a∨天堂| 少妇人妻无码专区视频| 亚洲精品久久久久久久久久久| 日本大片免a费观看视频三区| 国产成人无码18禁午夜福利网址| 另类亚洲小说图片综合区| 国产午夜无码片在线观看| 一区二区国产高清视频在线| 天天天欲色欲色www免费| 中文字幕乱码一区二区三区免费 | 在办公室被c到呻吟的动态图| 在线看免费无码av天堂| 免费国产黄网站在线观看视频| 午夜福利国产成人a∨在线观看| 精品伊人久久久大香线蕉下载| 精品无码专区亚洲| 国产看黄网站又黄又爽又色| 精品人妻系列无码人妻免费视频 | 欧美性色老妇人| 又色又爽又黄的视频网站| 色综合久久88色综合天天| 亚洲国产成人精品福利| 亚洲欧洲日产无码中文字幕| 国内精品久久久久影院一蜜桃| 精品人妻一区二区三区四区| 欧美成人h亚洲综合在线观看| 亚洲国产av导航第一福利网| 久久精品国产丝袜人妻| 开心五月综合亚洲| 亚洲精品国偷自产在线99人热 |