在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. AGAP2 Antibody

AGAP2 Antibody

  • 中文名稱：
    AGAP2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001427GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AGAP-2 antibody; Agap2 antibody; Agap2 ArfGAP with GTPase domain; ankyrin repeat and PH domain 2 antibody; AGAP2_HUMAN antibody; ANK repeat and PH domains 2 antibody; Arf GAP with GTP binding protein like antibody; Arf GAP with GTP-binding protein-like; ANK repeat and PH domains 2 antibody; Arf GAP with GTP-binding protein-like; ankyrin repeat and pleckstrin homology domains 2 antibody; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 2 antibody; ArfGAP with GTPase domain; ankyrin repeat and PH domain 2 antibody; Centaurin gamma 1 antibody; centaurin gamma1 antibody; Centaurin-gamma-1 antibody; Centg1 antibody; cnt g1 antibody; Cnt-g1 antibody; Cnt2 antibody; FLJ16430 antibody; GGAP2 antibody; GTP binding and GTPase activating protein 2 antibody; GTP-binding and GTPase activating protein 2 antibody; GTP-binding and GTPase-activating protein 2 antibody; KIAA0167 antibody; mKIAA0167 antibody; Nuclear GTPase PIKE antibody; Phosphatidylinositol 3-kinase enhancer antibody; Phosphoinositide 3 kinase enhancer antibody; PI3K ENHANCER antibody; PIKE antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human AGAP2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
  • 基因功能參考文獻(xiàn)：
    1. A pleckstrin homology domain in PIKE-L directly binds alpha-synuclein and antagonizes its aggregation. Accordingly, PIKE-L overexpression decreases dopaminergic cell death elicited by MPP(+), whereas PIKE-L knockdown elevates alpha-synuclein oligomerization and cell death. PMID: 28096359
    2. these findings support that PIKE amplification or overexpression coordinately acts with CDK4 to drive glioblastoma tumorigenesis. PMID: 28368413
    3. Studies showed that overexpression or mutation of PIKE has been observed in a variety of tumors, promoting cancer cell growth, transformation and invasion through AKT signaling or other signaling pathways, such as focal adhesion kinase. [review] PMID: 26977005
    4. Mutation of Fyn phosphorylation sites on PIKE-A, depletion of Fyn, or pharmacological inhibition of Fyn blunts the association between PIKE-A and AMPK, resulting in loss of its inhibitory effect on AMPK. PMID: 26001218
    5. expression of PLC-gamma1 and PIKE positively correlated with the tumor differentiation of oral squamous cell carcinoma. PMID: 26464646
    6. PIKE reduction rescued PI3K-dependent and -independent neuronal defects in fragile X syndrome. PMID: 25921541
    7. In this review the CENTG1 gene is amplified in a variety of human cancers which lead to the enhancement of tumor invasion. PMID: 23770988
    8. AGAP2 plays a role in the signalling and recycling of beta2-adrenergic receptors. PMID: 23527545
    9. Fyn regulates the activity of the adipogenic transcription factor signal transducer and activator of transcription 5a (STAT5a) through enhancing its interaction with the GTPase phosphoinositide 3-kinase enhancer A (PIKE-A). PMID: 23438599
    10. PIKE is highly expressed in human squamous cell carcinoma and has a critical role in EGF-induced squamous cell carcinoma proliferation. PMID: 22349826
    11. The presence of heterogeneous missense mutations of GGAP2 in prostate cancer was associated with aggressive clinical behavior. PMID: 22389719
    12. PIKE is a critical factor in controlling synaptic AMPA receptor insertion. PMID: 21847098
    13. Akt-phosphorylated PIKE-A inhibits UNC5B-induced apoptosis in cancer cell lines in a p53-dependent manner. [PIKE-A] PMID: 21460185
    14. regulates retrograde protein transport between early endosomes and the Golgi complex PMID: 20551179
    15. This study have identified, cloned and characterized PIKE-L, which localizes to both the cytoplasm and the nucleus, activates mGlur1 enhances formation of an mGluRI-Homer-PIKE-L complex, then activates PI3 kinase activity and prevents neuronal apoptosis. PMID: 14528310
    16. a physiologic regulator of Akt and an oncogenic effector of cell invasion PMID: 14761976
    17. PIKE binds PI 3-kinase & stimulates its lipid kinase activity. There are 3 isoforms which function throught the cell and meadiate processes from invasiveness to apoptosis. Review. PMID: 15951849
    18. The AGAP2 colocalized with AP-1, transferrin receptor and Rab4 on endosomes. Overexpression of AGAP2 changed the intracellular distribution of AP-1 and promoted Rab4-dependent fast recycling of transferrin. PMID: 16079295
    19. an important role of PIKE gene aberrations in the molecular pathogenesis of primary glioblastomas PMID: 16150119
    20. Fyn is essential for phosphorylating PIKE-A and protects it from apoptotic cleavage. PMID: 16841086
    21. The results of this study indicate that centaurins could be more accurately classified as NTPases and point to alternative mechanisms of cell signalling control. PMID: 17037982
    22. Myxoma virus (MV) M-T5 host range protein is functionally interchangeable with the host PIKE-A protein and that the activation of host Akt by either M-T5 or PIKE-A is critical for the permissiveness of cancer cells for MV. PMID: 17151107
    23. PIKE-A acts as a proto-oncogene, promoting cell transformation through Akt activation. PMID: 17297440
    24. Ectopic expression of AGAP2 causes both BRAG2 and the coiled bodies' marker coilin to accumulate in nucleoli. PMID: 17461797
    25. The cytoplasmic-nuclear shuttling of PIKE is dynamically regulated by the balancing actions of the lipid-binding property of both the split PH domain and the nuclear targeting function of its nuclear localization sequence. PMID: 18371979
    26. In normal mice. PIKE-L strongly binds SET and prevents its degradation by AEP, leading to resistance of neuronal cell death. PMID: 18374643
    27. PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system PMID: 18469807
    28. Cdk5 phosphorylates PIKE-A and stimulates its GTPase activity, which activates nuclear Akt and promotes glioblastoma cell migration and invasion. PMID: 18487454
    29. Increased GGAP2 expression, which is present in three quarters of human prostate cancers, can activate two critical pathways that have been linked to prostate cancer initiation and progression. PMID: 19176382
    30. AGAP2 regulates the FAK activity and the focal adhesion disassembly during cell migration. PMID: 19318351

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Cytoplasm.
  • 蛋白家族：
    Centaurin gamma-like family
  • 組織特異性：
    Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 16921

    OMIM: 605476

    KEGG: hsa:116986

    STRING: 9606.ENSP00000449241

    UniGene: Hs.302435



主站蜘蛛池模板： 久久欧美国产伦子伦精品| 国产无遮挡又黄又爽免费网站| 国产精品国产三级国产a| 欧洲极品无码一区二区三区| 亚洲热无码av一区二区东京热av| 亚洲精品成人网线在线播放va| 国产深夜福利视频在线| 两性色午夜视频免费无码| 日日躁夜夜躁狠狠久久av| 亚洲一区二区三区丝袜| 日日摸天天摸爽爽狠狠97| 奇米综合四色77777久久| 国产高清视频在线观看97| 亚洲精品1卡2卡三卡23卡| 国产午夜福利视频在线观看| 亚洲国产精品综合久久网络| 亚洲精品v天堂中文字幕| 久久久www成人免费看片| 免费人成在线观看网站品爱网| 无套内射在线观看theporn| 性欧美vr高清极品| 最大胆裸体人体牲交| 亚洲国产精品日韩av不卡在线| 三级理论中文字幕在线播放| 中文字幕无线码成人免费看| 777午夜福利理论电影网| 天天爽夜夜爽夜夜爽精品视频| 孕妇怀孕高潮潮喷视频孕妇| 亚洲精品高清国产一久久| 精品久久久久久久无码| 激情五月综合色婷婷一区二区| 日韩精品无码一区二区| 中文无码精品a∨在线观看| 亚洲男人的天堂www| 欧美性xxxxx极品少妇直播| 欧美国产精品日韩在线| 亚洲精品久久久久久婷婷| 久久精品国产只有精品2020| 韩国精品视频一区二区在线播放| 小sao货水好多真紧h视频| 在线中文字幕乱码英文字幕正常|